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Dr. Jin has over 20 years of experience in interdisciplinary biomedical research at NIH and is currently the Chief of the Nanoinstrumentation and Force Spectroscopy Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB. His current projects include independent initiatives and collaborations with scientists and clinicians across the NIH campus and around the world. He earned a physics degree from Nanjing University in China and came to USA through the CUSPEA scholarship. He holds a Master's degree in experimental physics from Penn State University and his doctoral degree in theoretical/mathematical physics from the University of Maryland College Park in 1992. Dr. Jin is a member of the Biophysical Society, the American Society for Cell Biology, and the American Chemical Society.
Dr. Albert Jin’s current research focuses in the areas of biomedical imaging, macromolecular biophysics, biotechnology, and nanomedicine. Most recently, his research has involved studies of biological and lipid membranes, malaria vaccine proteins, subcellular trafficking and cellular dynamics, biomechanics, multifunctional theranostics, and biomaterials. Dr. Jin’s primary research tools are atomic force microscopy (AFM), high-resolution optical and fluorescent spectroscopic imaging, and quartz-crystal microbalance with dissipation (QCM-D) measurements. He has also built several precision biomedical research instruments used at NIH. Additionally, to optimize data interpretation and outcomes, he seeks to improve strategies for complex data analysis and biomedical modeling methods.
Publications
A Type I Photosensitizer-Polymersome Boosts Reactive Oxygen Species Generation by Forcing H-Aggregation for Amplifying STING Immunotherapy.
Wang ZMa WYang ZKiesewetter DOWu YLang LZhang GNakuchima SChen JSu YHan SWu LGJin AJHuang W
J Am Chem Soc
2024 Oct 23
Advanced Nitric Oxide Generating Nanomedicine for Therapeutic Applications.
Wang ZJin AYang ZHuang W
ACS Nano
2023 May 23
Structural and immunological differences in Plasmodium falciparum sexual stage transmission-blocking vaccines comprised of Pfs25-EPA nanoparticles.
MacDonald NJSingh KReiter KNguyen VShimp RGittis AGChen BBurkhardt MZhang BWang ZHerrera RMoler MLee DYOrr-Gonzalez SHerrod JLambert LERausch KMMuratova OJones DSWu YJin AJGarboczi DNDuffy PENarum DL
NPJ Vaccines
2023 Apr 15
Hydrogen sulfide activatable metal-organic frameworks for Fluorescence Imaging-Guided Photodynamic Therapy of colorectal cancer.
Li HHuang MWei ZHe JMa YLu CJin AWang ZWen L
Front Bioeng Biotechnol
2022
Rational design of semiconducting polymer brushes as cancer theranostics.
Yang ZLi LJin AJHuang WChen X
Mater Horiz
2020 Jun 01
Vesicle Shrinking and Enlargement Play Opposing Roles in the Release of Exocytotic Contents.
Shin WArpino GThiyagarajan SSu RGe LMcDargh ZGuo XWei LShupliakov OJin AO'Shaughnessy BWu LG
Cell Rep
2020 Jan 14
Rational Design of All-Organic Nanoplatform for Highly Efficient MR/NIR-II Imaging-Guided Cancer Phototheranostics.
Hu XChen ZJin AJYang ZGan DWu AAo HHuang WFan Q
Small
2021 Mar
Wet/Sono-Chemical Synthesis of Enzymatic Two-Dimensional MnO Nanosheets for Synergistic Catalysis-Enhanced Phototheranostics.
Tang WFan WZhang WYang ZLi LWang ZChiang YLLiu YDeng LHe LShen ZJacobson OAronova MAJin AXie JChen X
Adv Mater
2019 May
Polyrotaxane-based supramolecular theranostics.
Yu GYang ZFu XYung BCYang JMao ZShao LHua BLiu YZhang FFan QWang SJacobson OJin AGao CTang XHuang FChen X
Nat Commun
2018 Feb 22
Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy.
Zhu GLynn GMJacobson OChen KLiu YZhang HMa YZhang FTian RNi QCheng SWang ZLu NYung BCWang ZLang LFu XJin AWeiss IDVishwasrao HNiu GShroff HKlinman DMSeder RAChen X
Nat Commun
2017 Dec 05
Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy.
Zhu GMei LVishwasrao HDJacobson OWang ZLiu YYung BCFu XJin ANiu GWang QZhang FShroff HChen X
Nat Commun
2017 Nov 14
Effects of gold nanoparticles on lipid packing and membrane pore formation.
Bhat AEdwards LWFu XBadman DLHuo SJin AJLu Q
Appl Phys Lett
2016 Dec 26
Hierarchical Assembly of Bioactive Amphiphilic Molecule Pairs into Supramolecular Nanofibril Self-Supportive Scaffolds for Stem Cell Differentiation.
Wang ZZhang FWang ZLiu YFu XJin AYung BCChen WFan JYang XNiu GChen X
J Am Chem Soc
2016 Nov 16
Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane.
Wen PJGrenklo SArpino GTan XLiao HSHeureaux JPeng SYChiang HCHamid EZhao WDShin WNäreoja TEvergren EJin YKarlsson REbert SNJin ALiu APShupliakov OWu LG
Nat Commun
2016 Aug 31
Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation.
Sousa RLiao HSCuéllar JJin SValpuesta JMJin AJLafer EM
Nat Struct Mol Biol
2016 Sep
Self-assembly mechanisms of nanofibers from peptide amphiphiles in solution and on substrate surfaces.
Liao HSLin JLiu YHuang PJin AChen X
Nanoscale
2016 Aug 04
DNA-inorganic hybrid nanovaccine for cancer immunotherapy.
Zhu GLiu YYang XKim YHZhang HJia RLiao HSJin ALin JAronova MLeapman RNie ZNiu GChen X
Nanoscale
2016 Mar 28
Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions.
Doyle ADCarvajal NJin AMatsumoto KYamada KM
Nat Commun
2015 Nov 09
Protein-based photothermal theranostics for imaging-guided cancer therapy.
Rong PHuang PLiu ZLin JJin AMa YNiu GYu LZeng WWang WChen X
Nanoscale
2015 Oct 21
Tumor-Specific Formation of Enzyme-Instructed Supramolecular Self-Assemblies as Cancer Theranostics.
Huang PGao YLin JHu HLiao HSYan XTang YJin ASong JNiu GZhang GHorkay FChen X
ACS Nano
2015 Oct 27
Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains.
Herrera RAnderson CKumar KMolina-Cruz ANguyen VBurkhardt MReiter KShimp RHoward RFSrinivasan PNold MJRagheb DShi LDeCotiis MAebig JLambert LRausch KMMuratova OJin AReed SGSinnis PBarillas-Mury CDuffy PEMacDonald NJNarum DL
Infect Immun
2015 Oct
Polymeric Nanovehicle Regulated Spatiotemporal Real-Time Imaging of the Differentiation Dynamics of Transplanted Neural Stem Cells after Traumatic Brain Injury.
Wang ZWang YWang ZZhao JGutkind JSSrivatsan AZhang GLiao HSFu XJin ATong XNiu GChen X
ACS Nano
2015 Jul 28
Erratum: Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles.
Chiang HCShin WZhao WDHamid ESheng JBaydyuk MWen PJJin AMomboisse FWu LG
Nat Commun
2015 Jan 27
Optical and photoacoustic dual-modality imaging guided synergistic photodynamic/photothermal therapies.
Yan XHu HLin JJin AJNiu GZhang SHuang PShen BChen X
Nanoscale
2015 Feb 14
Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide.
Yan XNiu GLin JJin AJHu HTang YZhang YWu ALu JZhang SHuang PShen BChen X
Biomaterials
2015 Feb
Early-stage imaging of nanocarrier-enhanced chemotherapy response in living subjects by scalable photoacoustic microscopy.
Nie LHuang PLi WYan XJin AWang ZTang YWang SZhang XNiu GChen X
ACS Nano
2014 Dec 23
Dye-loaded ferritin nanocages for multimodal imaging and photothermal therapy.
Huang PRong PJin AYan XZhang MGLin JHu HWang ZYue XLi WNiu GZeng WWang WZhou KChen X
Adv Mater
2014 Oct 08
Versatile RNA interference nanoplatform for systemic delivery of RNAs.
Choi KYSilvestre OFHuang XMin KHHoward GPHida NJin AJCarvajal NLee SWHong JIChen X
ACS Nano
2014 May 27
Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance.
Bhirde AAChikkaveeraiah BVSrivatsan ANiu GJin AJKapoor AWang ZPatel SPatel VGorbach AMLeapman RDGutkind JSHight Walker ARChen X
ACS Nano
2014 May 27
Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles.
Chiang HCShin WZhao WDHamid ESheng JBaydyuk MWen PJJin AMomboisse FWu LG
Nat Commun
2014
Acetylcholinesterase-catalyzed hydrolysis allows ultrasensitive detection of pathogens with the naked eye.
Liu DWang ZJin AHuang XSun XWang FYan QGe SXia NNiu GLiu GHight Walker ARChen X
Angew Chem Int Ed Engl
2013 Dec 23
VEGF-loaded graphene oxide as theranostics for multi-modality imaging-monitored targeting therapeutic angiogenesis of ischemic muscle.
Sun ZHuang PTong GLin JJin ARong PZhu LNie LNiu GCao FChen X
Nanoscale
2013 Aug 07
Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen.
Liu DHuang XWang ZJin ASun XZhu LWang FMa YNiu GHight Walker ARChen X
ACS Nano
2013 Jun 25
Development of a Pfs25-EPA malaria transmission blocking vaccine as a chemically conjugated nanoparticle.
Shimp RLRowe CReiter KChen BNguyen VAebig JRausch KMKumar KWu YJin AJJones DSNarum DL
Vaccine
2013 Jun 19
Unraveling protein-protein interactions in clathrin assemblies via atomic force spectroscopy.
Jin AJLafer EMPeng JQSmith PDNossal R
Methods
2013 Mar
Fabrication of hydrogels with steep stiffness gradients for studying cell mechanical response.
Sunyer RJin AJNossal RSackett DL
PLoS One
2012
A nanoscale graphene oxide-peptide biosensor for real-time specific biomarker detection on the cell surface.
Wang ZHuang PBhirde AJin AMa YNiu GNeamati NChen X
Chem Commun (Camb)
2012 Oct 09
Nuclear mapping of nanodrug delivery systems in dynamic cellular environments.
Bhirde AAKapoor ALiu GIglesias-Bartolome RJin AZhang GXing RLee SLeapman RDGutkind JSChen X
ACS Nano
2012 Jun 26
Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP.
Uchime OHerrera RReiter KKotova SShimp RLMiura KJones DLebowitz JAmbroggio XHurt DEJin AJLong CMiller LHNarum DL
Eukaryot Cell
2012 May
Functional MnO nanoclusters for efficient siRNA delivery.
Xing RLiu GQuan QBhirde AZhang GJin ABryant LHZhang ALiang AEden HSHou YChen X
Chem Commun (Camb)
2011 Nov 28
Enhanced mechanical rigidity of hydrogels formed from enantiomeric peptide assemblies.
Nagy KJGiano MCJin APochan DJSchneider JP
J Am Chem Soc
2011 Sep 28
Combining portable Raman probes with nanotubes for theranostic applications.
Bhirde AALiu GJin AIglesias-Bartolome RSousa AALeapman RDGutkind JSLee SChen X
Theranostics
2011
AFM visualization of clathrin triskelia under fluid and in air.
Kotova SPrasad KSmith PDLafer EMNossal RJin AJ
FEBS Lett
2010 Jan 04
Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate.
Plassmeyer MLReiter KShimp RLKotova SSmith PDHurt DEHouse BZou XZhang YHickman MUchime OHerrera RNguyen VGlen JLebowitz JJin AJMiller LHMacDonald NJWu YNarum DL
J Biol Chem
2009 Sep 25
Characterization of a protective Escherichia coli-expressed Plasmodium falciparum merozoite surface protein 3 indicates a non-linear, multi-domain structure.
Tsai CWDuggan PFJin AJMacdonald NJKotova SLebowitz JHurt DEShimp RLLambert LMiller LHLong CASaul ANarum DL
Mol Biochem Parasitol
2009 Mar
A Mycobacterium tuberculosis-derived lipid inhibits membrane fusion by modulating lipid membrane domains.
Hayakawa ETokumasu FNardone GAJin AJHackley VADvorak JA
Biophys J
2007 Dec 01
Measuring the elasticity of clathrin-coated vesicles via atomic force microscopy.
Jin AJPrasad KSmith PDLafer EMNossal R
Biophys J
2006 May 01
Titin PEVK segment: charge-driven elasticity of the open and flexible polyampholyte.
Forbes JGJin AJMa KGutierrez-Cruz GTsai WLWang K
J Muscle Res Cell Motil
2005
Evaluation of the metal binding properties of a histidine-rich fusogenic peptide by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.
Sinz AJin AJZschörnig O
J Mass Spectrom
2003 Nov
Atomic force microscopy of nanometric liposome adsorption and nanoscopic membrane domain formation.
Tokumasu FJin AJFeigenson GWDvorak JA
Ultramicroscopy
2003
Nanoscopic lipid domain dynamics revealed by atomic force microscopy.
Tokumasu FJin AJFeigenson GWDvorak JA
Biophys J
2003 Apr
Lipid membrane phase behaviour elucidated in real time by controlled environment atomic force microscopy.
Tokumasu FJin AJDvorak JA
J Electron Microsc (Tokyo)
2002