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The primary research interest is the development of methods to radiolabel biologically relevant molecules in which the introduction of 18F can be easily and efficiently accomplished. Examples of these small molecules include the anticancer drug analog [18F]Paclitaxel, the HIV drug analog [18F]FPMPA, and the muscarinic agonist [18F]xanomeline. An expansion of this interest is the preparation of small radiolabeled organic prosthetic groups that can subsequently be used to radiolabel larger molecules, such as peptides or proteins. Prosthetic groups may contain hydroxysuccinimidyl esters for selective conjugation with lysine residues or maleimidyl moieties for selective conjugation with cysteine residues. Recently, we described the conjugation of [18F]FBEM (fluorobenzoylaminoethyl maleimide) with HER2-specific Affibody molecule, an scVEGF fragment and with a cysteine-containing analog of exendin-4. These projects have yielded radiotracers with potential clinical applications.
In order to extend the probes available for PET, we have explored other available radionuclides. The group previously had collaborative projects in the use of Br-76 (t1/2 16.2 h) and Zr-89 (t ½ 78.4h). The synthesis of NOTA modified peptides that allow complexation of [18F]aluminum fluoride as well as Ga-68 (t1/2 68 min) and Cu-64 (t1/2, 12.7 h) are used extensively in the laboratory.
Publications
Unraveling the dynamics of B7-H3-targeting therapeutic antibodies in cancer through PET imaging and antibody pharmacokinetics.
Fernandes BOlkowski CPGhaemi BBasuli FShi JKiesewetter DOLang LElijah ESwenson RChoyke PLLin FIJacobson O
J Control Release
2025 Mar 10
A Type I Photosensitizer-Polymersome Boosts Reactive Oxygen Species Generation by Forcing H-Aggregation for Amplifying STING Immunotherapy.
Wang ZMa WYang ZKiesewetter DOWu YLang LZhang GNakuchima SChen JSu YHan SWu LGJin AJHuang W
J Am Chem Soc
2024 Oct 23
Distributable, metabolic PET reporting of tuberculosis.
Khan RMNAhn YMMarriner GAVia LED'Hooge FSeo Lee SYang NBasuli FWhite AGTomko JAFrye LJScanga CAWeiner DMSutphen MLSchimel DMDayao EPiazza MKGomez FDieckmann WHerscovitch PMason NSSwenson RKiesewetter DOBackus KMGeng YRaj RAnthony DCFlynn JLBarry CEDavis BG
Nat Commun
2024 Jun 27
Distributable, Metabolic PET Reporting of Tuberculosis.
Naseer Khan RMAhn YMMarriner GAVia LED'Hooge FLee SSYang NBasuli FWhite AGTomko JAFrye LJScanga CAWeiner DMSutphen MLSchimel DMDayao EPiazza MKGomez FDieckmann WHerscovitch PMason NSSwenson RKiesewetter DOBackus KMGeng YRaj RAnthony DCFlynn JLBarry CEDavis BG
bioRxiv
2023 Apr 03
Array
Thakur SDaley BMillo CCochran CJacobson OLu HWang ZKiesewetter DChen XVasko VKlubo-Gwiezdzinska J
Clin Cancer Res
2021 Mar 01
Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics.
Tian RZeng QZhu SLau JChandra SErtsey RHettie KSTeraphongphom THu ZNiu GKiesewetter DOSun HZhang XAntaris ALBrooks BRChen X
Sci Adv
2019 Sep
3-F-fluoropropane-1-thiol and F-PEG-1-thiol: Versatile prosthetic groups for radiolabeling maleimide functionalized peptides.
Jacobson OWang ZYu GMa YChen XKiesewetter DO
Bioorg Med Chem
2019 Oct 01
Organosilica-Based Hollow Mesoporous Bilirubin Nanoparticles for Antioxidation-Activated Self-Protection and Tumor-Specific Deoxygenation-Driven Synergistic Therapy.
Shan LFan WWang WTang WYang ZWang ZLiu YShen ZDai YCheng SJacobson OZhai KHu JMa YKiesewetter DOGao GChen X
ACS Nano
2019 Aug 27
In situ polymerization on nanoscale metal-organic frameworks for enhanced physiological stability and stimulus-responsive intracellular drug delivery.
Liu YGong CSDai YYang ZYu GLiu YZhang MLin LTang WZhou ZZhu GChen JJacobson OKiesewetter DOWang ZChen X
Biomaterials
2019 Oct
Tumor Microenvironment-Activated Ultrasensitive Nanoprobes for Specific Detection of Intratumoral Glutathione by Ratiometric Photoacoustic Imaging.
Tang LYu FTang BYang ZFan WZhang MWang ZJacobson OZhou ZLi LLiu YKiesewetter DOTang WHe LMa YNiu GZhang XChen X
ACS Appl Mater Interfaces
2019 Aug 07
Improving the Theranostic Potential of Exendin 4 by Reducing the Renal Radioactivity through Brush Border Membrane Enzyme-Mediated Degradation.
Zhang MJacobson OKiesewetter DOMa YWang ZLang LTang LKang FDeng HYang WNiu GWang JChen X
Bioconjug Chem
2019 Jun 19
An Albumin Sandwich Enhances in Vivo Circulation and Stability of Metabolically Labile Peptides.
Tian RZhu SZeng QLang LMa YKiesewetter DOLiu YFu XLau JZhu GJacobson OWang ZDai YYu GBrooks BRLiu GNiu GChen X
Bioconjug Chem
2019 Jun 19
A Logic-Gated Modular Nanovesicle Enables Programmable Drug Release for On-Demand Chemotherapy.
Tang LYang ZZhou ZMa YKiesewetter DOWang ZFan WZhu SZhang MTian RLang LNiu GZhang XChen X
Theranostics
2019
In Situ Dendritic Cell Vaccine for Effective Cancer Immunotherapy.
Yang WZhu GWang SYu GYang ZLin LZhou ZLiu YDai YZhang FShen ZLiu YHe ZLau JNiu GKiesewetter DOHu SChen X
ACS Nano
2019 Mar 26
Rational design of a super-contrast NIR-II fluorophore affords high-performance NIR-II molecular imaging guided microsurgery.
Tian RMa HYang QWan HZhu SChandra SSun HKiesewetter DONiu GLiang YChen X
Chem Sci
2019 Jan 07
Antidiabetic Effect of Abextide, a Long-Acting Exendin-4 Analogue in Cynomolgus Monkeys.
Niu GWang GLau JLang LJacobson OMa YKiesewetter DOZhang SChen X
Adv Healthc Mater
2019 Jun
Single Low-Dose Injection of Evans Blue Modified PSMA-617 Radioligand Therapy Eliminates Prostate-Specific Membrane Antigen Positive Tumors.
Wang ZTian RNiu GMa YLang LSzajek LPKiesewetter DOJacobson OChen X
Bioconjug Chem
2018 Sep 19
Automated radiosynthesis of [F]FBEM, a sulfhydryl site specific labeling agent for peptides and proteins.
Lim KRopchan JKiesewetter DOChen XHuang Y
Appl Radiat Isot
2018 Oct
Repurposing Cyanine NIR-I Dyes Accelerates Clinical Translation of Near-Infrared-II (NIR-II) Bioimaging.
Zhu SHu ZTian RYung BCYang QZhao SKiesewetter DONiu GSun HAntaris ALChen X
Adv Mater
2018 Jul 09
Radioligand Therapy of Prostate Cancer with a Long-Lasting Prostate-Specific Membrane Antigen Targeting Agent Y-DOTA-EB-MCG.
Wang ZJacobson OTian RMease RCKiesewetter DONiu GPomper MGChen X
Bioconjug Chem
2018 Jul 18
Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat.
Thompson SJPitcher MHStone LSTarum FNiu GChen XKiesewetter DOSchweinhardt PBushnell MC
Pain
2018 Sep
A paclitaxel prodrug with bifunctional folate and albumin binding moieties for both passive and active targeted cancer therapy.
Shan LZhuo XZhang FDai YZhu GYung BCFan WZhai KJacobson OKiesewetter DOMa YGao GChen X
Theranostics
2018
Evans Blue Attachment Enhances Somatostatin Receptor Subtype-2 Imaging and Radiotherapy.
Tian RJacobson ONiu GKiesewetter DOWang ZZhu GMa YLiu GChen X
Theranostics
2018
Engineered Zn(II)-Dipicolylamine-Gold Nanorod Provides Effective Prostate Cancer Treatment by Combining siRNA Delivery and Photothermal Therapy.
Min KHKim YHWang ZKim JKim JSKim SHKim KKwon ICKiesewetter DOChen X
Theranostics
2017
Quantification of Tumor Vascular Permeability and Blood Volume by Positron Emission Tomography.
Chen HTong XLang LJacobson OYung BCYang XBai RKiesewetter DOMa YWu HNiu GChen X
Theranostics
2017
PET-Guided Evaluation and Optimization of Internalized Antibody-Drug Conjugates Targeting Erythropoietin-Producing Hepatoma A2 Receptor.
Jacobson OLi QChen HNiu GKiesewetter DOXu LCook KYang GDall'Acqua WTsui PPeng LChen X
J Nucl Med
2017 Nov
Correction to "Novel F Activatable Probe for the Detection of Matrix Metalloprotease-2 Activity by MRI/MRS".
Yue XWang ZZhu LWang YQian CMa YKiesewetter DONiu GChen X
Mol Pharm
2017 Apr 03
Novel "Add-On" Molecule Based on Evans Blue Confers Superior Pharmacokinetics and Transforms Drugs to Theranostic Agents.
Chen HJacobson ONiu GWeiss IDKiesewetter DOLiu YMa YWu HChen X
J Nucl Med
2017 Apr
Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery.
Tong XWang ZSun XSong JJacobson ONiu GKiesewetter DOChen X
Theranostics
2016
Albumin-Binding Evans Blue Derivatives for Diagnostic Imaging and Production of Long-Acting Therapeutics.
Jacobson OKiesewetter DOChen X
Bioconjug Chem
2016 Oct 19
Monitoring Tumor Hypoxia Using (18)F-FMISO PET and Pharmacokinetics Modeling after Photodynamic Therapy.
Tong XSrivatsan AJacobson OWang YWang ZYang XNiu GKiesewetter DOZheng HChen X
Sci Rep
2016 Aug 22
A photothermally responsive nanoprobe for bioimaging based on Edman degradation.
Liu YWang ZZhang HLang LMa YHe QLu NHuang PLiu YSong JLiu ZGao SMa QKiesewetter DOChen X
Nanoscale
2016 May 19
Chemical Conjugation of Evans Blue Derivative: A Strategy to Develop Long-Acting Therapeutics through Albumin Binding.
Chen HWang GLang LJacobson OKiesewetter DOLiu YMa YZhang XWu HZhu LNiu GChen X
Theranostics
2016
Glucagon-Like Peptide-1 Receptor PET/CT with 68Ga-NOTA-Exendin-4 for Detecting Localized Insulinoma: A Prospective Cohort Study.
Luo YPan QYao SYu MWu WXue HKiesewetter DOZhu ZLi FZhao YChen X
J Nucl Med
2016 May
68Ga-NOTA-Exendin-4 PET/CT in Localization of an Occult Insulinoma and Appearance of Coexisting Esophageal Carcinoma.
Luo YLi NKiesewetter DOChen XLi F
Clin Nucl Med
2016 Apr
Stable Evans Blue Derived Exendin-4 Peptide for Type 2 Diabetes Treatment.
Liu YWang GZhang HMa YLang LJacobson OKiesewetter DOZhu LGao SMa QChen X
Bioconjug Chem
2016 Jan 20
Al[18F]NOTA-T140 Peptide for Noninvasive Visualization of CXCR4 Expression.
Yan XNiu GWang ZYang XKiesewetter DOJacobson OShen BChen X
Mol Imaging Biol
2016 Feb
Boramino acid as a marker for amino acid transporters.
Liu ZChen HChen KShao YKiesewetter DONiu GChen X
Sci Adv
2015 Sep
NIR-Responsive On-Demand Release of CO from Metal Carbonyl-Caged Graphene Oxide Nanomedicine.
He QKiesewetter DOQu YFu XFan JHuang PLiu YZhu GLiu YQian ZChen X
Adv Mater
2015 Nov
18F-Labeled Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression.
Jacobson OWeiss IDWang LWang ZYang XDewhurst AMa YZhu GNiu GKiesewetter DOVasdev NLiang SHChen X
J Nucl Med
2015 Nov
One-step (18)F labeling of biomolecules using organotrifluoroborates.
Liu ZLin KSBénard FPourghiasian MKiesewetter DOPerrin DMChen X
Nat Protoc
2015 Sep
Novel Method for Radiolabeling and Dimerizing Thiolated Peptides Using (18)F-Hexafluorobenzene.
Jacobson OYan XMa YNiu GKiesewetter DOChen X
Bioconjug Chem
2015 Oct 21
Design of a functional cyclic HSV1-TK reporter and its application to PET imaging of apoptosis.
Wang ZWang FHida NKiesewetter DOTian JNiu GChen X
Nat Protoc
2015 May
Quantitative Evaluation of Tumor Early Response to a Vascular-Disrupting Agent with Dynamic PET.
Guo NZhang FZhang XGuo JLang LKiesewetter DONiu GLi QChen X
Mol Imaging Biol
2015 Dec
PET imaging of tenascin-C with a radiolabeled single-stranded DNA aptamer.
Jacobson OYan XNiu GWeiss IDMa YSzajek LPShen BKiesewetter DOChen X
J Nucl Med
2015 Apr
Intrinsically radioactive [64Cu]CuInS/ZnS quantum dots for PET and optical imaging: improved radiochemical stability and controllable Cerenkov luminescence.
Guo WSun XJacobson OYan XMin KSrivatsan ANiu GKiesewetter DOChang JChen X
ACS Nano
2015 Jan 27
In vivo albumin labeling and lymphatic imaging.
Wang YLang LHuang PWang ZJacobson OKiesewetter DOAli IUTeng GNiu GChen X
Proc Natl Acad Sci U S A
2015 Jan 06
Fluorine-18 radiochemistry, labeling strategies and synthetic routes.
Jacobson OKiesewetter DOChen X
Bioconjug Chem
2015 Jan 21
68Ga-NOTA-exendin-4 PET/CT in detection of occult insulinoma and evaluation of physiological uptake.
Luo YYu MPan QWu WZhang TKiesewetter DOZhu ZLi FChen XZhao Y
Eur J Nucl Med Mol Imaging
2015 Mar
Bioinspired nanocomplex for spatiotemporal imaging of sequential mRNA expression in differentiating neural stem cells.
Wang ZZhang RWang ZWang HFWang YZhao JWang FLi WNiu GKiesewetter DOChen X
ACS Nano
2014 Dec 23
Novel 19F activatable probe for the detection of matrix metalloprotease-2 activity by MRI/MRS.
Yue XWang ZZhu LWang YQian CMa YKiesewetter DONiu GChen X
Mol Pharm
2014 Nov 03
[(18)F]DPA-714 PET imaging of AMD3100 treatment in a mouse model of stroke.
Wang YYue XKiesewetter DOWang ZLu JNiu GTeng GChen X
Mol Pharm
2014 Oct 06
Chelator-free (64)Cu-integrated gold nanomaterials for positron emission tomography imaging guided photothermal cancer therapy.
Sun XHuang XYan XWang YGuo JJacobson OLiu DSzajek LPZhu WNiu GKiesewetter DOSun SChen X
ACS Nano
2014 Aug 26
In Vivo Labeling of Serum Albumin for PET.
Niu GLang LKiesewetter DOMa YSun ZGuo NGuo JWu CChen X
J Nucl Med
2014 Jul
One-pot two-step radiosynthesis of a new (18)F-labeled thiol reactive prosthetic group and its conjugate for insulinoma imaging.
Yue XYan XWu CNiu GMa YJacobson OShen BKiesewetter DOChen X
Mol Pharm
2014 Nov 03
A symmetrical fluorous dendron-cyanine dye-conjugated bimodal nanoprobe for quantitative 19F MRI and NIR fluorescence bioimaging.
Wang ZYue XWang YQian CHuang PLizak MNiu GWang FRong PKiesewetter DOMa YChen X
Adv Healthc Mater
2014 Aug
Retraction note to: Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. Age (2012) 35(3): 597-608.
Gao FTaha AYMa KChang LKiesewetter DRapoport SI
Age (Dordr)
2014 Jun
A cyclic HSV1-TK reporter for real-time PET imaging of apoptosis.
Wang FWang ZHida NKiesewetter DOMa YYang KRong PLiang JTian JNiu GChen X
Proc Natl Acad Sci U S A
2014 Apr 08
Longitudinal PET imaging of muscular inflammation using 18F-DPA-714 and 18F-Alfatide II and differentiation with tumors.
Wu CYue XLang LKiesewetter DOLi FZhu ZNiu GChen X
Theranostics
2014
PET imaging of neuroinflammation in a rat traumatic brain injury model with radiolabeled TSPO ligand DPA-714.
Wang YYue XKiesewetter DONiu GTeng GChen X
Eur J Nucl Med Mol Imaging
2014 Jul
Stability analysis of glutamic acid linked peptides coupled to NOTA through different chemical linkages.
Lang LMa YKiesewetter DOChen X
Mol Pharm
2014 Nov 03
Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy.
Rong PYang KSrivastan AKiesewetter DOYue XWang FNie LBhirde AWang ZLiu ZNiu GWang WChen X
Theranostics
2014
Self-illuminating 64Cu-doped CdSe/ZnS nanocrystals for in vivo tumor imaging.
Sun XHuang XGuo JZhu WDing YNiu GWang AKiesewetter DOWang ZLSun SChen X
J Am Chem Soc
2014 Feb 05
Rational design of matrix metalloproteinase-13 activatable probes for enhanced specificity.
Zhu LMa YKiesewetter DOWang YLang LLee SNiu GChen X
ACS Chem Biol
2014 Feb 21
(18)F-alfatide II and (18)F-FDG dual-tracer dynamic PET for parametric, early prediction of tumor response to therapy.
Guo JGuo NLang LKiesewetter DOXie QLi QEden HSNiu GChen X
J Nucl Med
2014 Jan
Comparison of three dimeric 18F-AlF-NOTA-RGD tracers.
Guo JLang LHu SGuo NZhu LSun ZMa YKiesewetter DONiu GXie QChen X
Mol Imaging Biol
2014 Apr
Development of a new thiol site-specific prosthetic group and its conjugation with [Cys(40)]-exendin-4 for in vivo targeting of insulinomas.
Yue XKiesewetter DOGuo JSun ZZhang XZhu LNiu GMa YLang LChen X
Bioconjug Chem
2013 Jul 17
Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging.
Wang ZZhang XHuang PZhao WLiu DNie LYue XWang SMa YKiesewetter DNiu GChen X
Biomaterials
2013 Aug
Comparison of (18)F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression.
Zhang XXSun ZGuo JWang ZWu CNiu GMa YKiesewetter DOChen X
Mol Imaging Biol
2013 Dec
pH-sensitive fluorescent dyes: are they really pH-sensitive in cells?
Zhang XXWang ZYue XMa YKiesewetter DOChen X
Mol Pharm
2013 May 06
Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver.
Gao FTaha AYMa KChang LKiesewetter DRapoport SI
Age (Dordr)
2013 Jun
Evaluation of an [(18)F]AlF-NOTA Analog of Exendin-4 for Imaging of GLP-1 Receptor in Insulinoma.
Kiesewetter DOGuo NGuo JGao HZhu LMa YNiu GChen X
Theranostics
2012
PET of glucagonlike peptide receptor upregulation after myocardial ischemia or reperfusion injury.
Gao HKiesewetter DOZhang XHuang XGuo NLang LHida NWang HWang HCao FNiu GChen X
J Nucl Med
2012 Dec
The synthesis and in vivo pharmacokinetics of fluorinated arachidonic acid: implications for imaging neuroinflammation.
Pichika RTaha AYGao FKotta KCheon YChang LKiesewetter DRapoport SIEckelman WC
J Nucl Med
2012 Sep
Site-Specific Labeling of scVEGF with Fluorine-18 for Positron Emission Tomography Imaging.
Wang HGao HGuo NNiu GMa YKiesewetter DOChen X
Theranostics
2012
Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model.
Guo NLang LLi WKiesewetter DOGao HNiu GXie QChen X
PLoS One
2012
PET of HER2-positive pulmonary metastases with 18F-ZHER2:342 affibody in a murine model of breast cancer: comparison with 18F-FDG.
Kramer-Marek GBernardo MKiesewetter DOBagci UKuban MAras OZielinski RSeidel JChoyke PCapala J
J Nucl Med
2012 Jun
Quantitative analysis and parametric imaging of 18F-labeled monomeric and dimeric RGD peptides using compartment model.
Guo NLang LGao HNiu GKiesewetter DOXie QChen X
Mol Imaging Biol
2012 Dec
Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes.
Huang XZhang FLee SSwierczewska MKiesewetter DOLang LZhang GZhu LGao HChoi HSNiu GChen X
Biomaterials
2012 Jun
Potential of PET to predict the response to trastuzumab treatment in an ErbB2-positive human xenograft tumor model.
Kramer-Marek GGijsen MKiesewetter DOBennett RRoxanis IZielinski RKong ACapala J
J Nucl Med
2012 Apr
Longitudinal PET imaging of doxorubicin-induced cell death with 18F-Annexin V.
Hu SKiesewetter DOZhu LGuo NGao HLiu GHida NLang LNiu GChen X
Mol Imaging Biol
2012 Dec
Evaluation of fluorine-labeled gastrin-releasing peptide receptor (GRPR) agonists and antagonists by LC/MS.
Ma YYang MGao HNiu GYan YLang LKiesewetter DOChen X
Amino Acids
2012 Oct
PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer 18F-AlF-NOTA-PRGD2.
Gao HLang LGuo NCao FQuan QHu SKiesewetter DONiu GChen X
Eur J Nucl Med Mol Imaging
2012 Apr
N-Succinimidyl 4-[(18)F]-fluoromethylbenzoate-labeled dimeric RGD peptide for imaging tumor integrin expression.
Li WLang LNiu GGuo NMa YKiesewetter DOShen BChen X
Amino Acids
2012 Sep
18F-radiolabeled analogs of exendin-4 for PET imaging of GLP-1 in insulinoma.
Kiesewetter DOGao HMa YNiu GQuan QGuo NChen X
Eur J Nucl Med Mol Imaging
2012 Mar
Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate.
Liu GChoi KYBhirde ASwierczewska MYin JLee SWPark JHHong JIXie JNiu GKiesewetter DOLee SChen X
Angew Chem Int Ed Engl
2012 Jan 09
PET imaging of EGF receptors using [18F]FBEM-EGF in a head and neck squamous cell carcinoma model.
Li WNiu GLang LGuo NMa YKiesewetter DOBacker JMShen BChen X
Eur J Nucl Med Mol Imaging
2012 Feb
Improvement of CXCR4 tracer specificity for PET imaging.
Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOPeled AEden HSFarber JMChen X
J Control Release
2012 Jan 30
Usefulness of [18F]-DA and [18F]-DOPA for PET imaging in a mouse model of pheochromocytoma.
Martiniova LCleary SLai EWKiesewetter DOSeidel JDawson LFPhillips JKThomasson DChen XEisenhofer GPowers JFKvetnansky RPacak K
Nucl Med Biol
2012 Feb
Imaging of the muscarinic acetylcholine neuroreceptor in rats with the M2 selective agonist [18F]FP-TZTP.
Ravasi LTokugawa JNakayama TSeidel JSokoloff LEckelman WCKiesewetter DO
Nucl Med Biol
2012 Jan
Positron emission tomography imaging of tumors expressing the human chemokine receptor CXCR4 in mice with the use of 64Cu-AMD3100.
Weiss IDJacobson OKiesewetter DOJacobus JPSzajek LPChen XFarber JM
Mol Imaging Biol
2012 Feb
Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice.
Lang LLi WGuo NMa YZhu LKiesewetter DOShen BNiu GChen X
Bioconjug Chem
2011 Dec 21
New Methods for Labeling RGD Peptides with Bromine-76.
Lang LLi WJia HMFang DCZhang SSun XZhu LMa YShen BKiesewetter DONiu GChen X
Theranostics
2011
Striatal adenosine A(2A) receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [(18)F]-MRS5425.
Bhattacharjee AKLang LJacobson OShinkre BMa YNiu GTrenkle WCJacobson KAChen XKiesewetter DO
Nucl Med Biol
2011 Aug
PET of insulinoma using ¹⁸F-FBEM-EM3106B, a new GLP-1 analogue.
Gao HNiu GYang MQuan QMa YMurage ENAhn JMKiesewetter DOChen X
Mol Pharm
2011 Oct 03
Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet.
Gao FKim HWIgarashi MKiesewetter DChang LMa KRapoport SI
Biochim Biophys Acta
2011
PET imaging of CXCR4 using copper-64 labeled peptide antagonist.
Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOFarber JMChen X
Theranostics
2011
Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain.
Jacobson OWeiss IDNiu GBalboni GCongiu COnnis VKiesewetter DOLattanzi RSalvadori SChen X
J Nucl Med
2011 Apr
PET imaging of early response to the tyrosine kinase inhibitor ZD4190.
Yang MGao HYan YSun XChen KQuan QLang LKiesewetter DNiu GChen X
Eur J Nucl Med Mol Imaging
2011 Jul
Rapid and simple one-step F-18 labeling of peptides.
Jacobson OZhu LMa YWeiss IDSun XNiu GKiesewetter DOChen X
Bioconjug Chem
2011 Mar 16
[(76) Br]BMK-152, a nonpeptide analogue, with high affinity and low nonspecific binding for the corticotropin-releasing factor type 1 receptor.
Jagoda EMLang LMcCullough KContoreggi CKim BMMa YRice KCSzajek LPEckelman WCKiesewetter DO
Synapse
2011 Sep
MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptides.
Jacobson OZhu LNiu GWeiss IDSzajek LPMa YSun XYan YKiesewetter DOLiu SChen X
Mol Imaging Biol
2011 Dec
Increased uptake of [¹²³I]meta-iodobenzylguanidine, [¹⁸F]fluorodopamine, and [³H]norepinephrine in mouse pheochromocytoma cells and tumors after treatment with the histone deacetylase inhibitors.
Martiniova LPerera SMBrouwers FMAlesci SAbu-Asab MMarvelle AFKiesewetter DOThomasson DMorris JCKvetnansky RTischler ASReynolds JCFojo ATPacak K
Endocr Relat Cancer
2011 Feb
Automated radiochemical synthesis of [18F]FBEM: a thiol reactive synthon for radiofluorination of peptides and proteins.
Kiesewetter DOJacobson OLang LChen X
Appl Radiat Isot
2011 Feb
LC/MS evaluation of metabolism and membrane transport of bombesin peptides.
Gu DMa YNiu GYan YLang LAisa HAGao HKiesewetter DOChen X
Amino Acids
2011 Feb
PET of tumor CXCR4 expression with 4-18F-T140.
Jacobson OWeiss IDKiesewetter DOFarber JMChen X
J Nucl Med
2010 Nov
Quantifying conversion of linoleic to arachidonic and other n-6 polyunsaturated fatty acids in unanesthetized rats.
Gao FKiesewetter DChang LRapoport SIIgarashi M
J Lipid Res
2010 Oct
Applications of LC-MS in PET radioligand development and metabolic elucidation.
Ma YKiesewetter DOLang LGu DChen X
Curr Drug Metab
2010 Jul
Antiretroviral tissue kinetics: in vivo imaging using positron emission tomography.
Di Mascio MSrinivasula SBhattacharjee ACheng LMartiniova LHerscovitch PLertora JKiesewetter D
Antimicrob Agents Chemother
2009 Oct
Whole-body synthesis secretion of docosahexaenoic acid from circulating eicosapentaenoic acid in unanesthetized rats.
Gao FKiesewetter DChang LMa KRapoport SIIgarashi M
J Lipid Res
2009 Dec
Changes in HER2 expression in breast cancer xenografts after therapy can be quantified using PET and (18)F-labeled affibody molecules.
Kramer-Marek GKiesewetter DOCapala J
J Nucl Med
2009 Jul
Application of highly sensitive UPLC-MS to determine biodistribution at tracer doses: validation with the 5-HT1A ligand [(18)F]FPWAY.
Ma YLang LReyes LTokugawa JJagoda EMKiesewetter DO
Nucl Med Biol
2009 May
64Cu-AMD3100--a novel imaging agent for targeting chemokine receptor CXCR4.
Jacobson OWeiss IDSzajek LFarber JMKiesewetter DO
Bioorg Med Chem
2009 Feb 15
Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography.
Kiesewetter DOLang LMa YBhattacharjee AKGao ZGJoshi BVMelman Ade Castro SJacobson KA
Nucl Med Biol
2009 Jan
Whole-body synthesis-secretion rates of long-chain n-3 PUFAs from circulating unesterified alpha-linolenic acid in unanesthetized rats.
Gao FKiesewetter DChang LMa KBell JMRapoport SIIgarashi M
J Lipid Res
2009 Apr
Radiolabeling of HER2 specific Affibody(R) molecule with F-18.
Kiesewetter DOKrämer-Marek GMa YCapala J
J Fluor Chem
2008 Sep
Enantiomeric radiochemical synthesis of R and S (1-(6-amino-9H-purin-9-yl)-3-fluoropropan-2-yloxy)methylphosphonic acid (FPMPA).
Kiesewetter DOKnudson KCollins MSrinivasula SLim EDi Mascio M
J Labelled Comp Radiopharm
2008 Mar 13
[18F]FBEM-Z(HER2:342)-Affibody molecule-a new molecular tracer for in vivo monitoring of HER2 expression by positron emission tomography.
Kramer-Marek GKiesewetter DOMartiniova LJagoda ELee SBCapala J
Eur J Nucl Med Mol Imaging
2008 May
An automated one-step one-pot [(18)F]FCWAY synthesis: development and minimization of chemical impurities.
Vuong BKKiesewetter DOLang LMa YEckelman WCChanning MA
Nucl Med Biol
2007 May
Evaluation of [18F]fluoroxanomeline {5-{4-[(6-[18F]fluorohexyl)oxy]-1,2,5-thiadiazol-3-yl}-1-methyl-1,2,3,6-tetrahydropyridine} in muscarinic knockout mice.
Kiesewetter DOJagoda EMShimoji KMa YEckelman WC
Nucl Med Biol
2007 Feb
Automated synthesis of 18F analogue of paclitaxel (PAC): [18F]Paclitaxel (FPAC).
Kalen JDHirsch JIKurdziel KAEckelman WCKiesewetter DO
Appl Radiat Isot
2007 Jun
Species differences in metabolites of PET ligands: serotonergic 5-HT1A receptor antagonists 3-trans-FCWAY and 3-cis-FCWAY.
Ma YLang LKiesewetter DJagoda EEckelman WC
Nucl Med Biol
2006 Nov
Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder.
Cannon DMCarson RENugent ACEckelman WCKiesewetter DOWilliams JRollis DDrevets MGandhi SSolorio GDrevets WC
Arch Gen Psychiatry
2006 Jul
Development of 5-HT1A receptor radioligands to determine receptor density and changes in endogenous 5-HT.
Jagoda EMLang LTokugawa JSimmons AMa YContoreggi CKiesewetter DEckelman WC
Synapse
2006 May
Estimation of paclitaxel biodistribution and uptake in human-derived xenografts in vivo with (18)F-fluoropaclitaxel.
Gangloff AHsueh WAKesner ALKiesewetter DOPio BSPegram MDBeryt MTownsend ACzernin JPhelps MESilverman DH
J Nucl Med
2005 Nov
Purification of the precursor for the automated radiosynthesis of [18F]FCWAY by counter-current chromatography.
Ma YLang LKiesewetter DOVuong BKChanning MIto YEckelman WC
J Chromatogr A
2004 Apr 23
A potential cholinergic mechanism of procaine's limbic activation.
Benson BECarson REKiesewetter DOHerscovitch PEckelman WCPost RMKetter TA
Neuropsychopharmacology
2004 Jul
Application of LC-MS to the analysis of new radiopharmaceuticals.
Ma YKiesewetter DLang LEckelman WC
Mol Imaging Biol
2003
Routine quality control of recycled target [18O]water by capillary electrophoresis and gas chromatography.
Huang BXChanning MAPlascjak PSKiesewetter DODer MMa YEckelman WC
Nucl Med Biol
2003 Oct
Inhibition of [18F]FP-TZTP binding by loading doses of muscarinic agonists P-TZTP or FP-TZTP in vivo is not due to agonist-induced reduction in cerebral blood flow.
Shimoji KEsaki TItoh YRavasi LCook MJehle JJagoda EMKiesewetter DOSchmidt KSokoloff LEckelman WC
Synapse
2003 Nov
Biodistribution, radiation dose estimates, and in vivo Pgp modulation studies of 18F-paclitaxel in nonhuman primates.
Kurdziel KAKiesewetter DOCarson REEckelman WCHerscovitch P
J Nucl Med
2003 Aug
Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-epsilon4 allele.
Cohen RMPodruchny TABokde ALCarson REHerscovitch PKiesewetter DOEckelman WCSunderland T
Synapse
2003 Sep 01
Determination of [18F]FCWAY, [18F]FP-TZTP, and their metabolites in plasma using rapid and efficient liquid-liquid and solid phase extractions.
Ma YKiesewetter DOLang LDer MHuang BCarson REEckelman WC
Nucl Med Biol
2003 Apr
In vivo muscarinic 2 receptor imaging in cognitively normal young and older volunteers.
Podruchny TAConnolly CBokde AHerscovitch PEckelman WCKiesewetter DOSunderland TCarson RECohen RM
Synapse
2003 Apr
The automated radiosynthesis of [18F]FP-TZTP.
Kiesewetter DOVuong BKChanning MA
Nucl Med Biol
2003 Jan
Fluoro-, bromo-, and iodopaclitaxel derivatives: synthesis and biological evaluation.
Kiesewetter DOJagoda EMKao CHMa YRavasi LShimoji KSzajek LPEckelman WC
Nucl Med Biol
2003 Jan
Liquid chromatography-tandem mass spectrometry identification of metabolites of three phenylcarboxyl derivatives of the 5-HT(1A) antagonist, N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridyl) trans-4-fluorocyclohexanecarboxamide (FCWAY), produced by human and rat hepatocytes.
Ma YLang LKiesewetter DOEckelman WC
J Chromatogr B Analyt Technol Biomed Life Sci
2002 Nov 15
Identification of metabolites of fluorine-18-labeled M2 muscarinic receptor agonist, 3-(3-[(3-fluoropropyl)thio]-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine, produced by human and rat hepatocytes.
Ma YKiesewetter DOJagoda EMHuang BXEckelman WC
J Chromatogr B Analyt Technol Biomed Life Sci
2002 Jan 25
Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener.
Kiesewetter DOJagoda EMStarrett JEGribkoff VKHewawasam PSrinivas NSalazar DEckelman WC
Nucl Med Biol
2002 Jan