Epigenetics & RNA Biology Laboratory

Paul A. Wade, Ph.D. Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator Tel 984-287-4133 Fax 919-541-0146 wadep2@niehs.nih.gov

Traci M. Hall, Ph.D. Deputy Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator Tel 984-287-3556 Fax 301-480-3055 hall4@niehs.nih.gov

Research Summary

The Epigenetics and RNA Biology Laboratory investigates fundamental mechanisms by which epigenetics — non-genetic modulation and alterations — influences chromatin architecture, transcription and gene expression in normal, cancer and embryonic stem cells and provides insights into biological processes that modulate the effects of environmental exposures. It also focuses on the molecular basis of self-renewal and pluripotency in embryonic stem (ES) cells and induced pluripotency stem (iPS) cells, as well as gene regulatory pathways using genomic, molecular, biochemical, computational and structural approaches.

In addition to the cutting edge hypothesis driven research of its investigators the laboratory provides leadership and support to the NIEHS in areas of genomics, epigenomics, mass spectrometry, and bioinformatics analyses. These endeavors build and research strengths established in the prior Laboratory of Molecular Carcinogenesis and extend the scope of the research beyond cancer to examine a broad range of environmental impacts on human health and development.

Principal Investigators

Chromatin & Gene Expression

Trevor K. Archer, Ph.D. Deputy Director, NIEHS; NIH Distinguished Investigator Tel 984-287-4000 Fax 919-316-4566 archer1@niehs.nih.gov

Eukaryotic Transcriptional Regulation

Paul A. Wade, Ph.D. Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator Tel 984-287-4133 Fax 919-541-0146 wadep2@niehs.nih.gov

Macromolecular Structure

Traci M. Hall, Ph.D. Deputy Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator Tel 984-287-3556 Fax 301-480-3055 hall4@niehs.nih.gov