David M. Crizer, Ph.D.

Mechanistic Toxicology Branch

Image

David Crizer, Ph.D., is a chemist in the Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT). Before joining DTT he completed his doctorate in Analytical Chemistry at the University of North Carolina at Chapel Hill under the direction of Gary Glish. At UNC his dissertation research focused on the use of mass spectrometry, differential ion mobility, and theoretical chemistry to understand novel ion chemistries.

His work at DTT is focused on the development of mass spectrometry-based untargeted metabolomic methods to aid in the screening of potentially toxic substances. His research also includes analytical method development for hepatic clearance assays, specific activity assays, and metabolite profiling assays. Other interests include the investigation of in silico metabolite prediction and how predictions compare to in vitro data.

Crizer obtained his B.S. in Chemistry from James Madison University followed by a Ph.D. in Analytical Chemistry from University of North Carolina at Chapel Hill.

Insight into how metabolites affect health aided by new data platforms To study metabolome, a hybrid approach is needed, expert says Novel toxicity assessment strategies highlighted at DNTP board meeting