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Coronary Artery Risk Development in Young Adults (CARDIA) MRI Sub-Study (CARDIA-MRI) .
Objective: To identify risk factors for, and consequences of MRI-evident neurodegenerative and vascular brain changes in young-to-middle-aged subjects.
Design: Prospective longitudinal study of brain aging conducted in a sub-sample of the well-characterized prospective longitudinal CARDIA cohort of 5,115 Black and White young adults 18-30 years of age at baseline (1985-86) living in 4 centers in the US. Since 2010, three MRI scans have been acquired that include multi-sequences that measure structural and functional aspects of the brain.
Data: Deeply phenotyped with digital, clinical, biospecimen, and questionnaire data.
Honolulu Asia Aging Study [HAAS]
Objective: To study the early and concurrent risk factors related to dementia, and to characterize the aging brain based on clinical and neuropathologic data.
Design: The HAAS was an extension of the Honolulu Heart Program (1965-1971), which was a cohort of Japanese American men born 1900-1991, registered in the Selective Service rolls, and living on Oahu at the start of the study. The study included an examination of 3734 men (b. 1991) up to 12 times and an autopsy study offered to all participants.
Data: Clinical, questionnaire and neuropathological data.
Health, Aging and Body Composition Study [HABC]
Objective: To study how changes in body composition form a common pathway through which weight-related health conditions and behavioral factors contribute to functional decline and loss of independence in older persons.
Design: A longitudinal cohort (b.1997-98) in 3 US centers that included Black and White men and women aged 70-79 who were able to walk and climb stairs. Participants were seen yearly for six years and thereafter at 2 additional exams, with phone calls alternating every 6 months to update functional and health status.
Data: Deeply phenotyped with digital, clinical, biospecimen, and questionnaire data.
Objective: To Identify risk factors for loss of mobility; characterize events that lead to a progressive loss of mobility; and to identify the biological mechanisms leading to functional loss in old age.
Design: Prospective longitudinal cohort study (b. 1998) based in two sites in Tuscany, Italy.Participants are a random sample of 1,270 persons aged 65 years or older selected from the population registries, supplemented with random samples of 30 men and 30 from each of 10-year age strata starting at age 20. The cohort has been examined up to 5 times.
Data: Deeply phenotyped with digital, clinical, biospecimen, and questionnaire data.
Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-RS)
Objective: To examine potential genetic susceptibility and gene/environment interactions as these contribute to many conditions, disease and disability in old age.
Methods:TheAGES-RS is an extension of the Reykjavik Study (RS) initiated by the Icelandic Heart Association in 1967. The AGES-RS cohort includes 5764 men and women born between 1907 and 1935 and living in Reykjavik, Iceland in 1967; cohort members were seen up to 6 times in mid-life and 2 times in late-life.
Data: Deeply phenotyped with digital, clinical, biospecimen, and questionnaire data.
Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS)
Objective: To understand health disparities by disentangling relationships among race, socioeconomic status, health outcomes and normal age-related changes in function; and to identify biomarkers of these disparities.
Methods: HANDLS is a prospective cohort of 3,720 community-dwelling African American and White adults aged 30-64 at baseline (2004) who have been examined up to 4 times. Participants were recruited from Baltimore City neighborhoods with a wide range of socioeconomic and income circumstances in a 4-way factorial cross of age (seven five-year age bands between 30-64), sex, race, and socioeconomic status indexed by poverty status.
Data: Deeply phenotyped with digital, clinical, biospecimen, and questionnaire data.
Objective: To unravel in a founder population, the genetic processes involved in a wide range of quantitative traits, functional measures and diseases that change with aging.
Methods: The core study is a longitudinal prospective cohort of 6100 individuals 20 years and older living in 4 towns in eastern Sardinia (b. 2000) who have been examined up to 5 times.
Data: Deeply phenotyped with digital, clinical, biospecimen, and questionnaire data.