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The National Institute on Aging (NIA) is currently supporting 466 active clinical trials on Alzheimer’s disease and related dementias (AD/ADRD). These trials reflect diverse drug and mechanistic targets, as well as diversity in the stages of AD/ADRD they address. NIA’s active trials include: Clinical Drug Development – Phase I and II (50), Clinical Drug Development – Phase II/III, III, and IV (13), Nondrug (148), Dementia Care and Caregiving (203), Understanding Disease Processes (32), Diagnostic Tools, Assessments, & Imaging Studies (18), and Treatments for Neuropsychiatric Symptoms (2). Please see the tables below for more details about these trials.*
Please note: The data in the graphics are from March 2025.
On this page:
- Section 1: Clinical Drug Development – Phase I and II (50 trials)
- Section 2: Clinical Drug Development – Phase II/III, III, and IV (13 trials)
- Section 3: Nondrug (148 trials)
- Section 4: Dementia Care and Caregiver (203 trials)
- Section 5: Understanding Disease Processes (32 trials)
- Section 6: Diagnostic Tools, Assessments, & Imaging Studies (18 trials)
- Section 7: Treatments for Neuropsychiatric Symptoms (2 trials)
*The data in the tables below are from March 2025
Section 1: Clinical Drug Development – Phase I and II
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Clinical Trials to Prevent Alzheimer's Disease in Down Syndrome | Trial-Ready Cohort-Down Syndrome (TRC-DS) (TRC-DS) | Michael S. Rafii, University of Southern California | Anti-Aβ immunotherapy to remove amyloid plaques | Non-demented adults with down syndrome (Ages 35 - 55) | 2025 |
| A Seamless Phase 2A-B Randomized Double Blind Placebo Controlled Trial to Evaluate the Efficacy and Safety of PQ 912 in Patients with Early Alzheimer's Disease | A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD (VIVA-MIND) | Howard Feldman, University of California San Diego | PQ 912, a small molecule glutaminyl cyclase (QC) inhibitor to treat both amyloidopathy and neuroinflammation | Adults with mild cognitive impairment or mild probable Alzheimer's disease (Ages 50 - 89) | 2025 |
| A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Dementia with Lewy Bodies | Study to Evaluate the Safety, Tolerability and Efficacy of CT1812 in Subjects With Mild to Moderate Dementia With Lewy Bodies (COG1201) | Anthony Caggiano, Cognition Therapeutics Inc | CT1812, a small molecule sigma2 receptor antagonist that displaces Aß oligomers bound to neuronal receptors at synapses | Individuals with mild to moderate Lewy Body Dementia | 2025 |
| Safety/Tolerability/Immunogenicity of First-in-Human Aβ DNA Vaccine, AV-1959D Phase 1 Trials in Early-Stage AD Subjects: Based on IND18953 Cleared by FDA | Study of AV-1959, an Amyloid Beta Vaccine | Michael Agadjanyan, Institute For Molecular Medicine | AV-1959D, a DNA based vaccine targeting amyloid beta to reduce amyloid plaque | Early Alzheimer's disease participants (Ages 60 - 85 | 2027 |
| Randomized Double Blind, Placebo Controlled, Parallel Group Trial to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease over 18 Months | A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease | Anthony Caggiano, Cognition Therapeutics, Inc. | CT1812, a small molecule sigma2 receptor antagonist that displaces Aß oligomers bound to neuronal receptors at synapses | Older adults with early Alzheimer's disease, late mild cognitive impairment, and mild Alzheimer's disease dementia | 2027 |
| Early Clinical Development of Modified P8 for the Treatment of Alzheimer's Disease | Early Clinical Development of Modified P8 for the Treatment of Alzheimer's Disease | Nazneen Dewji, Cenna Biosciences, Inc. | Peptide drug mP8 to reduce toxic species of amyloid-beta | Healthy adults (Ages 18 - 55) and people with prodromal Alzheimer's disease (Ages 55 - 80) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Evaluating the Disease-Modifying Potential of a Sleep Intervention for Alzheimer's Disease Outcomes | Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging | Natalie Denburg, University of Iowa | Melatonin, a hormone that regulates sleep, to improve cognition in older adults | Older adults (Ages 60 - 75) | 2025 |
| Improving Sleep and AD Biomarkers: A Pilot RCT of Citicoline | Improving Sleep and AD Biomarkers | Victoria Pak, Emory University | Examine whether Citicoline (a dietary choline supplement) can significantly increase choline levels and decrease inflammatory and potentially Alzheimer's disease (AD)-associated biomarkers during a prodromal stage of AD (mild cognitive impairment due to AD) | Mild cognitive impairment (Ages 60+) | 2025 |
| Effect of Suvorexant on Alzheimer's Disease Biomarkers | DORA and LP in Alzheimer's Disease Biomarkers | Brendan Lucey, Washington University in St. Louis | Lemborexant, a dual orexin receptor antagonist sleep aid to decrease the amount of amyloid-beta and tau in the blood to prevent Alzheimer's disease | Cognitively healthy, amyloid-positive older adults (Ages 65+) | 2028 |
| RCT Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (Rest) | Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (REST) | Barry Greenberg, Johns Hopkins Bayview Medical Center | Trazadone, an antidepressant to treat sleep disturbance and improve cognitive outcomes | Individuals with prodromal Alzheimer's disease or amnestic Mild Cognitive Impairment and sleep complaints | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Clinical Trial of AAV2-BDNF Gene Therapy in Alzheimer's Disease | A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment | Mark Tuszynski, University of California San Diego | Brain Derived Neurotrophic Factor (BDNF) Gene Therapy to potentially slow or even reverse cognitive decline in Alzheimer’s disease | Adults with early Alzheimer's disease and/or mild cognitive impairment | 2026 |
| The LUCINDA Trial | The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's (LUCINDA) | Tracy Butler, Joan and Sanford I Weill Medical College of Cornell University | Lupron, a small molecule gonadotropin-releasing hormone (GnRH) receptor agonist to slow cognitive decline in women with mild to moderate Alzheimer's disease | Women with mild-moderate Alzheimer's disease who are also taking acetylcholinesterase (AChE) inhibitors (Ages 65 - 90) | 2025 |
| PhytoSERM for Menopausal Hot Flashes and Sustained Brain Health | PhytoSERM for Menopausal Hot Flashes and Sustained Brain Health (HF-Relief) | John Rinehart, Neutherapeutics, Llc | PhytoSERM, a selective estrogen receptor beta (ERß) modulator; a rationally designed formulation of 3 phytoestrogens, genistein, daidzein, and S-equol | Peri- and post-menopausal women (Ages 45 - 60) | 2025 |
| PhytoSERM to Prevent Menopause Associated Decline in Brain Metabolism and Cognition | PhytoSERM to Prevent Menopause Associated Decline in Brain Metabolism and Cognition | Roberta Brinton, University of Arizona | PhytoSERM, a selective estrogen receptor beta (ERß) modulator to improve brain metabolism and cognitive function | Peri- and post-menopausal women (Ages 45 - 60) | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients | MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients (MCLENA-1) | Marwan Sabbagh, Dignity Health's St. Joseph's Hospital and Medical Center | Lenalidomide, a small molecule Anti-inflammatory immunomodulator to reduce neuroinflammation and slow or prevent Alzheimer's disease | Adults with amnestic Mild Cognitive Impairment (Ages 50+) | 2025 |
| Phase II Trial of GM-CSF/sargramostim in Alzheimer's Disease | Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease (SESAD) | Huntington Potter, University Of Colorado Denver | Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Sargrammostim, an immune system modulator to improve cognition | Older adults with mild-to-moderate Alzheimer's disease | 2025 |
| BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a Trial | Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH) (BEACH) | Daniel Hanley, Johns Hopkins Bayview Medical Center | MW150, a small molecule inhibitor of p38alphaMAPK serine/threonine protein kinase to reduce neuroinflammation and improve synaptic function | Participants with spontaneous, non-traumatic, Intracranial Hemorrhage | 2025 |
| Central and Peripheral Immune Cross-Talk in Alzheimer's disease and their Modulation by a Novel Immunotherapy | Systemic and Central Inflammation in AD | Alireza Faridar, Houston Methodist Hospital Research Institute | Low-dose Interleukin-2 (IL-2) immunotherapy to reduce neuroinflammation and ameliorate Alzheimer's disease pathology | Participants with Alzheimer's disease (Ages 55 - 86) | 2025 |
| Phase 1 Trial to Assess Safety and Immune Effects of Xenon Gas in Healthy Human Subjects | Phase 1 Trial to Assess Safety and Immune Effects of Xenon Gas in Healthy Human Subjects | Ilya Ilin, General Biophysics, LLC | Evaluation of Xenon gas to reduce inflammation as a treatment for Alzheimer's disease | Healthy older adults (Ages 55 - 75) | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Effects of Orally Administered Nicotinamide Riboside on Bioenergetic Metabolism, Oxidative Stress and Cognition in Mild Cognitive Impairment and Mild Alzheimer's Dementia | Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia | Fei Du, McLean Hospital | Nicotinamide riboside (NR), an orally bioavailable precursor of NAD+, to enhance mitochondrial function, and improve cognition | Adults with mild cognitive impairment and mild Alzheimer’s disease (Ages 55 - 89) | 2025 |
| Phase II Randomized Controlled Trial of Benfotiamine in Early Alzheimer's Disease | A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam) | Gary Gibson, Winifred Masterson Burke Medical Research Institute | Benfotiamine, a small molecule thiamine derivative to improve cognition and overall global function | Individuals with early Alzheimer's disease, including mild cognitive impairment and mild dementia with plasma evidence of amyloid positivity | 2028 |
| Effects of NAD Restoration on Neurovascular Coupling in Community Dwelling Older Adults | The Effect of NAD Supplementation on Brain Vascular Health in Aging | Andriy Yabluchanskiy, University of Oklahoma | Nicotinamide Adenine Dinucleotide (NAD) supplementation to improve brain health and memory | Older adults (Ages 60 - 85) | 2027 |
| Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting- A Randomized Clinical Trial | Thiamine Intervention and Coronary Artery Bypass Grafting (B1&CABG) | Rajesh Kumar, University of California Los Angeles | Thiamine (vitamin B1), an essential micronutrient known to reduce anaerobic metabolism, intervention to improve quality of life and daily activities and reduce cognitive deficits | Adults with coronary heart disease undergoing coronary artery bypass grafting (Ages 60 – 80) | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Proof of Concept Trial of a Sirtuin-NAD+ Activator in Alzheimer's Disease | Sirtuin-NAD Activator in Alzheimer's Disease | Shalender Bhasin, Brigham and Women's Hospital | ß nicotinamide mononucleotide (ßNMN): An NAD+ precursor to slow Alzheimer's disease progression and improve cognition | Mild Alzheimer's disease dementia participants | 2025 |
| Repurposing Siponimod for Alzheimer's Disease | Repurposing Siponimod for Alzheimer's Disease | Marwan Sabbagh, Dignity Health's St. Joseph's Hospital and Medical Center | Siponimod, an immunomodulatory small molecule used to treat multiple sclerosis and serving as a neuroprotective, to lower the rate of brain atrophy | Individuals with early Alzheimer's disease (Ages 60 - 85) | 2027 |
| Citalopram as a Posterior Cortical Protective Therapy in Parkinson Disease | Citalopram as a Posterior Cortical Protective Therapy in Parkinson Disease | Vikas Kotagal, University of Michigan | Citalopram, a selective serotonin-reuptake inhibitor to test effect on amyloid-beta levels in the visuospatial cortex and visuospatial cognitive abilities in patients with Parkinson’s disease | Older adults with Parkinson's disease diagnosis and no active depression (Ages 65+) | 2025 |
| Allopregnanolone as Regenerative Therapeutic for Alzheimer's: Phase 2 Clinical Trial | Allopregnanolone Regenerative Therapeutic for Mild Alzheimer's Disease (REGEN-BRAIN©) | Roberta Brinton, University of Arizona | Allopregnanolone, a small molecule that stimulates anti-inflammatory mechanisms and mitochondrial function to regenerate neurons and restore cognition in Alzheimer's disease | Adults who are APOE e4 positive and diagnosed with mild Alzheimer's disease (Ages 55+) | 2026 |
| Cannabidiol for Individuals at Risk for Alzheimer's Disease: A Randomized Placebo Controlled Trial | CBD for Individuals at Risk for Alzheimer's Disease | Kent Hutchison, University of Colorado Anschutz Medical Campus | An intervention with full spectrum hemp-derived cannabidiol (CBD) and CBD to determine the influence on Alzheimer's disease biomarkers | Older adults with mild cognitive impairment (Ages 55 - 85) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Age-Related Mild Cognitive Impairment and Novel Protective Role of Glutathione: Implications for Alzheimer's Disease | Glutathione in Mild Cognitive Impairment | Rajagopal Sekhar, Baylor College of Medicine | Glutathione supplementation to improve cognition in Alzheimer's disease | Adults with mild cognitive impairment (Ages 65 - 80) | 2025 |
| Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease | Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease | Rajagopal Sekhar, Baylor College of Medicine | Glutathione supplementation to improve cognition in Alzheimer's disease | Adults with mild cognitive impairment and mild Alzheimer’s disease (Ages 55 - 85) | 2026 |
| Veri-T: A Phase 1 Placebo-Controlled Trial of Verdiperstat in Semantic Variant Primary Progressive Aphasia Due to Underlying FTLD-TDP | Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology (Veri-T-001) | Peter Ljubenkov, University of California San Francisco | Verdiperistat, a microglial myeloperoxidase inhibitor that modulates proinflammatory microglia | Participants with Semantic variant primary progressive aphasia (Ages 18 - 80) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| IND Enabling CMC/Safety/Toxicology Studies, Submission of IND and Pilot Phase 1 Clinical Trial with PV-1950R Vaccine for Lewy Body Dementia (LBD) | IND Enabling CMC/Safety/Toxicology Studies, Submission of IND and Pilot Phase 1 Clinical Trial with PV-1950R Vaccine for Lewy Body Dementia (LBD) | Michael Agadjanyan, Institute for Molecular Medicine | Evaluate the safety/tolerability and immunogenicity of PV-1950R/A vaccine | Healthy individuals (Phase 1a) and participants with Rapid Eye Movement Sleep Behavior Disorders (Phase 1b) | 2029 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Phase 1b Multiple Ascending Dose Study of the Safety and Tolerability of BMS-984923 in Alzheimer's Disease | Multiple Ascending Dose Study of the Safety and Tolerability of BMS-984923 | Adam Mecca, Yale University | BMS-984923, blocks aberrant Amyloid beta activation of mGluR5 | Adults with early Alzheimer's disease (Ages 50 - 80) | 2025 |
| Preclinical and Early Clinical Development of a GABA-A a5 PAM | Preclinical and Early Clinical Development of a GABA-A a5 PAM | Sharon Rosenzweig-Lipson, AgeneBio, Inc. | BPN-27473, a potent, selective and orally active GABA-A a5 Positive Allosteric Modulator (PAM) for the treatment of mild cognitive impairment due to Alzheimer's disease | Healthy Older Adults | 2026 |
| Clinical evaluation of BMS-984923 metabolism. | Clinical Evaluation of BMS-984923 Metabolism | Timothy Siegert, Allyx Therapeutics Inc. | BMS-984923, a small molecule silent allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), to prevent synapse damage in Alzheimer's disease | People with no history of cognitive impairment (Ages 50 - 80) | 2026 |
| Optimizing CNS DHA delivery in elderly adults at risk for dementia | Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia | Robert Mcnamara, University of Cincinnati | Lysophosphatidylcholine-DHA (LPC-DHA) supplementation to increase docosahexaenoic acid (DHA) levels and reduce neurodegenerative processes | People with subjective cognitive decline (Ages 62 - 80) | 2029 |
| Cognitive, Urinary, and Functional Trajectories of Older Women Using Pharmacologic Treatment Strategies for Urgency Incontinence | TReating Incontinence for Underlying Mental and Physical Health (TRIUMPH) | Alison Huang, University of California San Francisco | Tolterodine and Mirabegron, anticholinergic bladder medications | Older women with urinary incontinence and without pre-existing dementia | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| (-)-Phenserine Inhibition of Neuronal Death in Alzheimer’s Disease and Developing Brain-Labeled Plasma Exosomes Assays as Biomarkers for a Phenserine Phase 1b Ascending Dose Trial | (-)-Phenserine Inhibition of Neuronal Death in Alzheimer’s Disease and Developing Brain-Labeled Plasma Exosomes Assays as Biomarkers for a Phenserine Phase 1b Ascending Dose Trial | Lon S. Schneider, University of Southern California | (-)-PHENSERINE, a small molecule that inhibits neuronal pre-programmed cell death, to prevent neuronal dysfunction and death | Adults with probable Alzheimer's disease (Ages 70 - 82) | 2025 |
| Treating Hyperexcitability in Alzheimer’s Disease with Levetiracetam to Improve Brain Function and Cognition | Treating Hyperexcitability in AD With Levetiracetam (LeAD) | Mouhsin Shafi, Beth Israel Deaconess Medical Center | Levetiracetam, a small molecule synaptic vesicle protein (SV2A) modulator, to improve cognition in Alzheimer's disease | Adults with probable Alzheimer's disease (Ages 50 - 90) | 2024 |
| A Randomized, Double Blind, Placebo-Controlled Study to Evaluate the Impact of Nilotinib Treatment on Safety, Tolerability, Pharmacokinetics and Biomarkers in Dementia with Lewy Bodies (DLB) | Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Dementia With Lewy Bodies | Charbel Moussa, Georgetown University | Nilotinib, a small molecule inhibitor of Abelson kinase to facilitate degradation of neurotoxic proteins and promote survival of neurons | Adults with clinical diagnosis of Lewy body dementia with both dementia and Parkinsonism (Ages 25 - 90) | 2025 |
| Development of a Small-molecule that Enhances Tripartite Synapses for Alzheimer's Disease | Development of a Small-molecule that Enhances Tripartite Synapses for Alzheimer's Disease | Chien-Liang Glenn Lin, Ohio State University | A single ascending dose (SAD) study to determine safety and tolerability of a novel compound that has the potential for modifying Alzheimer's disease progression/onset | Healthy men and women (Ages 18 - 60) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| First in Human Study of a Tau Self-Association Small Molecule Inhibitor in Healthy Volunteers | Phase 1 Study of OLX-07010 in Healthy Adult and Elderly Participants | William Erhardt, Oligomerix, Inc | OLX-07010 is a tau self-association inhibitor small molecule that targets tau, a protein involved in disease progression | Healthy adults (ages 18 - 50) and healthy older adults (ages 51 - 75) | 2025 |
| The Alzheimer's Disease Tau Platform Clinical Trial | The Alzheimer's Disease Tau Platform Clinical Trial | Adam Boxer, University of California San Francisco | Tau-directed therapies, alone and in combination with an anti-amyloid therapy, to slow Alzheimer's disease progression | Older adults with elevated brain amyloid and tau (Ages 60 - 75) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid and Tau in Older Adults (IPAT-study) | Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study) (IPAT) | Rong Zhang, University of Texas Southwestern Medical Center | Intensive lowering of systolic blood pressure (SBP) using antihypertensive medications to reduce Alzheimer's disease pathology (i.e., excessive brain amyloid and tau protein deposition) in older adults at high risk for memory decline or dementia | Older adults who have hypertension (SBP=130 mmHg), family history of dementia, and/or subjective memory complaints (Ages 60 - 80) | 2027 |
| Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging (SMArT–HS) | Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging (SMArT-HS) | Gregory Jicha, University of Kentucky | Nicorandil, a small molecule agonist for sulfonyl urea receptor 2 protein (SUR2), to improve cognition and hippocampal pathology | Adults with probable Hippocampal sclerosis (HS)-aging (Ages 75+) | 2025 |
| Arterial Stiffness, Cognition, and Equol (ACE) | Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers (ACE) | Akira Sekikawa, University of Pittsburgh | Equol supplementation as an intervention to improve cognitive decline by targeting arterial stiffness and white matter lesions in the brain | Older adults (Ages 65+) | 2027 |
| The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults | The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults (Mito-Frail) | Oh Sung Kwon, University Of Connecticut Storrs | Determine if MitoQ supplementation will affect peripheral vasodilation, peripheral and cerebral nitric oxide (NO) bioavailability and mitochondrial reactive oxygen species (mtROS), cognitive function and gait speed | Older adults who are healthy, frail with slow walking speed (0.4m/s based on a 4m walk), and those who meet criteria for mild cognitive impairment (Ages 65 - 80) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Anti-Viral Therapy in Alzheimer's Disease | Anti-viral Therapy in Alzheimer's Disease | Davangere Devanand, Columbia University | Valacyclovir, an Antiviral (Herpes Simplex Virus drug) to examine if HSV contributes to the pathology of Alzheimer's disease and whether antiviral treatment can improve cognition | People with mild Alzheimer's disease | 2025 |
| The Use of Deferiprone to Improve Subarachnoid Hemorrhage Cognitive Outcome: U-DISCO | Ferritin and Iron Burden in SAH sIRB | David Hasan, Duke University | Deferiprone to improve cognitive outcomes | Adults with aneurysmal subarachnoid hemorrhage at risk for cognitive decline (Ages 18 - 70) | 2025 |
| Phase I Cell Therapy for Maintaining Cholinergic Circuits in the Spectrum of Alzheimer’s Disease | Phase I Cell Therapy for Maintaining Cholinergic Circuits in the Spectrum of Alzheimer’s Disease | Greg Gerhardt, University of Kentucky | Mixed-cell peripheral nerve tissue, reparative cells for neurons, to improve cognition | People with Parkinson’s disease (Ages 40 – 75) | 2029 |
Section 2: Clinical Drug Development – Phase II/III, III, and IV
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Open-Label Extension Study | Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss (A4) | Reisa Sperling, Brigham And Women's Hospital | Solanezumab, an anti-amyloidß antibody to prevent cognitive decline associated with early Alzheimer's disease pathology | Cognitively healthy older adults who are amyloid positive on brain imaging (Ages 65+) | 2024 |
| Combination Anti-amyloid Therapy for Preclinical Alzheimer's Disease (A-45) | AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid | Paul Aisen, University of Southern California | BAN2401, anti-amyloidß antibody to slow or prevent cognitive decline in cognitively normal preclinical individuals with Alzheimer's disease | Cognitively healthy older adults with "elevated" amyloid levels on screening PET (Ages 55 - 80; adults ages 55 - 64 must have an additional risk factor) | 2025 |
| Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study | An Efficacy and Safety Study of ALZ-801 in APOE4/4 Early AD Subjects (APOLLOE4) | Susan Abushakra, Alzheon Inc. | ALZ-801 (tramiprosate pro-drug), an inhibitor of Aß oligomer formation | Individuals with APOE e4 and early Alzheimer's disease diagnosis | 2025 |
| DIAN-TU Primary Prevention Trial | A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation (DIAN-TU) | Eric Mcdade, Washington University in St. Louis | Anti-amyloid therapy to prevent Alzheimer's disease | Cognitively healthy adults who are Alzheimer's disease genetic mutation carriers | 2026 |
| Alzheimers Prevention Initiative ADAD Colombia Trial Program | Alzheimer's Prevention Initiative ADAD Colombia Trial Program | Robert Alexander, Banner Alzheimer's Institute | Plaque-clearing antibody donanemab and a gamma-secretase modulator RG6289 to promote amyloid clearance | People from the Colombian kindred of presenilin 1 (PSEN1) E280A mutation carriers (Ages 30 - 60) | 2029 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Phase 2b Clinical Study of the P38 Alpha Kinase Inhibitor Neflamapimod in Patients with Mild-to-Moderate Dementia with Lewy Bodies (DLB) | A Clinical Study of Neflamapimod in Patient with Dementia with Lewy Bodies | John Alam, Eip Pharma, Inc. | Neflamapimod, inhibitor of p38 mitogen activated protein kinase alpha (p38a), to reduce neuronal degeneration | Mild-to-moderate dementia with Lewy bodies (Ages 55+) | 2026 |
| REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (with Baricitinib) for Long COVID Related ADRD | REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (with Baricitinib) for Long COVID Related ADRD | E. Wesley Ely, Vanderbilt University Medical Center | Barcitinib, an immunomodulator for acute COVID-19 (FDA approved), administered orally in patients with Long COVID to determine if Barcitinib improves brain function and physical impairment | Adults with Long COVID and cognitive impairment at high risk for long-term Alzheimer's disease and related dementias (ages 18+) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Metformin in Alzheimer's Dementia Prevention | Metformin in Alzheimer's Dementia Prevention (MAP) | Jose Alejandro Luchsinger, Columbia University | Metformin, a medication with proven efficacy in decreasing hyperinsulinemia and preventing diabetes, repurposed for the prevention of Alzheimer’s dementia | Adults with amnestic mild cognitive impairment (Ages 55 - 90) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Depression Treatment and Aβ dynamics: A Study of Alzheimer’s Disease Risk | Aß Dynamics in LLMD | Nunzio Pomara, New York University School of Medicine | Escitalopram Oxalate, a SSRI antidepressant to examine effects of Alzheimer's disease biomarkers | Older cognitively unimpaired adults with Major Depressive Disorder (Ages 60+) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| DIAN-TU: Tau Next Generation Prevention Trial | Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) | Randall Bateman, Washington University in St. Louis | Anti-tau therapy to prevent Alzheimer's disease | Cognitively healthy or mildly impaired adults who are Alzheimer's disease genetic mutation carriers | 2027 |
| The Progressive Supranuclear Palsy Clinical Trial Platform (PTP) | The Progressive Supranuclear Palsy Clinical Trial Platform (PTP) | Adam Boxer, University of California San Francisco (UCSF) | Three therapies (at least one tau and one neuroprotective) to improve cognitive function | People with progressive supranuclear palsy (Ages 40 - 85) | 2029 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| PRagmatic EValuation of evENTs And Benefits of Lipid-Lowering in oldEr Adults (PREVENTABLE) | Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults (PREVENTABLE) | Karen Alexander, Duke University | Atorvastatin, a statin to reduce death, dementia, and persistent disability | Community-dwelling adults without clinically evident cardiovascular disease, significant disability, or dementia (Ages 75+) | 2027 |
| Effectiveness of Implementing an Intensive Blood Pressure Reduction Intervention on Cognitive Decline in Low-income and Minority Hypertensive Patients | Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline (IMPACTS-MIND) | Katherine Mills, Tulane University | Multifaceted intensive blood pressure intervention to reduce blood pressure-related cognitive decline in underserved populations | Adults with hypertension who receive primary care from clinics that predominately manage underserved populations with health disparities | 2025 |
Section 3: Nondrug
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Developing a Mobile App-Based Intervention to Promote Cognitive Health in Older Chinese Americans | Cognitive Training RCT for Older Chinese Americans | Hanzhang Xu, Duke University | A mobile app-based cognitive training (aka mHealth) intervention that is culturally and linguistically relevant to older Chinese Americans to, ultimately, enhance cognitive function in the population. Includes dementia knowledge education, culturally-appropriate app content, cognitive training activities, and training reminders. | Older Chinese Americans without cognitive impairment and adult children of older Chinese Americans | 2025 |
| ACTIVE MIND: An Adaptive Clinical Trial of Cognitive Training to Improve Function and Delay Dementia | The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia | Jerri Edwards, University of Alabama at Birmingham | Combination of cognitive training exercises to modify the functional trajectories of adults with mild cognitive impairment | Older adults with mild cognitive impairment (Ages 65 - 89) | 2027 |
| Cognitive Training and Neuroplasticity in Mild Cognitive Impairment | Cognitive Training and Neuroplasticity in Mild Cognitive Impairment (CogTraining) | Davangere Devanand, Columbia University | Computerized cognitive training to improve cognitive performance | People with Mild Cognitive Impairment (Ages 55 - 95) | 2029 |
| The Adherence Promotion with Person-centered Technology (APPT) Project: Promoting Adherence to Enhance the Early Detection and Treatment of Cognitive Decline | Smart Reminders to Promote Home-based Cognitive Training | Walter Boot, Florida State University | Mobile platform-based support system intervention to improve adherence to home-based cognitive assessment | Non-cognitively impaired adults (Ages 65+) | 2025 |
| Prospective Memory Impairment in Parkinson Disease-related Cognitive Decline: Intervention and Mechanisms | Everyday Memory Impairment in PD-related Cognitive Decline (PMT2) | Erin Foster, Washington University in St. Louis | Memory encoding strategies to improve prospective memory | Adults who meet criteria for typical idiopathic Parkinson's disease (Ages 50+) | 2025 |
| Early Cognitive Training and Rehabilitation to Prevent Cognitive Decline in Older Hospitalized Adults with Delirium | Early Cognitive Intervention in Delirium (ECID) | Jin Han, Vanderbilt University Medical Center | Cognitive training rehabilitation program for individuals with delirium to improve working memory | Hospitalized older delirious patients with and without Alzheimer's disease and related dementias (Ages 65+) | 2025 |
| Transferring Speed of Processing Gains to Everyday Cognitive Tasks After Stroke | Transferring Speed of Processing Gains to Everyday Cognitive Tasks After Stroke | Gitendra Uswatte, University of Alabama at Birmingham | Web-based computer game that trains cognitive processing speed to improve everyday activities | Stroke Patients | 2025 |
| Cognitive Training to Reduce Incidence of Cognitive Impairment in Older Adults | Preventing Alzheimer's Disease with Cognitive Training (PACT) | Jennifer O'Brien, University of South Florida | Speed of processing training intervention to reduce incidence of mild cognitive impairment or dementia | Older adults who are cognitively normal | 2026 |
| Use of the KF Modified Story Memory Technique to Improve New Learning and Memory in Individuals with Mild Cognitive Impairment | Improve New Learning and Memory in Individuals With Mild Cognitive Impairment | Nancy Chiaravalloti, Kessler Foundation, Inc. | Kessler Foundation modified Story Memory Technique (KF-mSMT), a 10-session structured cognitive rehabilitation treatment composed of the application of imagery and context to facilitate learning | Older adults with mild cognitive impairment and no evidence of dementia (Ages 60+) | 2027 |
| Neuromechanisms of Falls in Older Adults with MCI: Targeting Assessment and Training of Reactive Balance Control | Dual Task Perturbation Training for OAwMCI | Tanvi Bhatt, University of Illinois at Chicago | A novel four-week perturbation-based cognitive-motor intervention for improving reactive balance control and cognition | Older adults with mild cognitive impairment or cognitively intact older adults (Ages 55+) | 2026 |
| Mindfulness to Enhance Cognitive Health in Latinx Older Adults at Risk for Alzheimers Disease | Mindfulness to Enhance Cognitive Health in Latinx Older Adults at Risk for Alzheimer's Disease | Todd Braver, Washington University in St. Louis | A culturally adapted mindfulness-based program to reduce Alzheimer's disease (AD) prevalence/burden within the Latinx community at high risk for age-related cognitive decline and AD-related neurodegeneration | Latinx older adults at risk of Alzheimer's Disease (Ages 65+ years) | 2026 |
| Using Artificial Intelligence to Predict Cognitive Training Response in Amnestic Mild Cognitive Impairment | Training Response Artificial Intelligence Network (TRAIN) | Joseph Gullett, University of Florida | Use of artificial intelligence in cognitive training for memory deficit-based disorders, which may increase the risk of Alzheimer’s disease | Adults with amnestic mild cognitive impairment (Ages 55 - 100) | 2028 |
| Develop an ANS-based Personalized Cognitive Training for Mild Cognitive Impairment | CogT pSOPT Intervention Study | Feng Lin, Stanford University | Personalized cognitive training program to slow cognitive decline; intervention is tailored using a participant's biofeedback and cognitive performance | People with mild cognitive impairment due to Alzheimer's disease (Ages 60 - 89) | 2026 |
| Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure | Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure | Miyeon Jung, Indiana University-Purdue University Indianapolis | Preliminary efficacy study of a combined intervention involving virtual reality-based cognitive restoration (Vita) coupled with computerized cognitive training (Com), compared to each intervention alone, and standard of care in a 4-group randomized controlled trial using a 2X2 factorial design | Dyads composed of older (65+ years) patients with HF (chronic HF Stage C validated from echocardiography or comparable measure) and MCI (MoCA score 23 and lower) and their informants | 2027 |
| Phase IIB Plasticity-based Adaptive Cognitive Remediation for Alzheimer's Disease | Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB (BETTER Aging) | Hyun Kyu Lee, Posit Science Corporation | Cognitive training intervention to improve cognitive and functional performance, while reducing pathology associated with Alzheimer's disease | Cognitively normal older adults (Ages 75+) | 2026 |
| Targeting Cognitive Control to Improve Physical Activity Adherence in Midlife for Alzheimer's Risk Reduction | Cognitive Control to Boost Physical Activity Adherence (BOOST) | Michelle Voss, University of Iowa | Computerized physical activity behavior change (PABC) programs to improve physical activity behavior change in inactive middle-age adults | Inactive middle-aged adults (Ages 40 - 65) | 2027 |
| vmPFCs Role in Adherence to Cognitive Training | Breathing, Relaxation, Attention Training, & Health in Older Adults (BREATHE) | Feng Lin, Stanford University | The ventromedial prefrontal cortex (vmPFC) function will be strengthened, via resonance frequency breathing training to achieve greater adherence to VSOP, a preventative strategy for cognitive aging | Persons with amnestic mild cognitive impairment and healthy controls (Ages 60-89) | 2025 |
| Web-based technology and cognitive training: improving executive control in cognitivelyhealthy older adults | Using Teleneuropsychology to Optimize Cognition in Healthy Aging: the Web-based Breakfast Game | Sharon Sanz Simon, Rutgers Biomedical and Health Sciences | The intervention includes a web-based cognitive training of Executive Control (EC) using an ecological Emphasis Change (EmCh) approach with a task named the Breakfast Game (B-Game) | Cognitively healthy older adult participants (Ages 60 - 75) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Influence of Strategy Training on Disability for Older Adults with Mild Cognitive Impairment | Facilitating Optimal Routines in Aging (ForAging) | Juleen Rodakowski, University of Pittsburgh | Strategy Training to slow the emergence of disability and decline in cognition | People with Mild Cognitive Impairment (Ages 60+) | 2024 |
| Targeted Physical and Cognitive Activity in a VR Environment in Older Adults at Risk for Alzheimer's Disease | Brain Health Virtual Reality Study | Judy Pa, University of California San Diego | Physical and cognitive activity program in a virtual reality environment to improve cognition | People with early Mild Cognitive Impairment (Ages 55 - 80) | 2026 |
| Sleep Interventions and Neurocognitive Outcomes in Amnestic Mild Cognitive Impairment | Sleep Interventions and Neurocognitive Outcomes | Hyun Kim, New York State Psychiatric Institute Research Foundation For Mental Hygiene, Inc. | Assess the neurocognitive effects of two sleep interventions (cognitive behavioral therapy for insomnia [CBTI] and acoustic slow-wave activity enhancement [SWAE]) and their underlying mechanisms in individuals with amnestic mild cognitive impairment | Older adults with sleep disturbance who meet criteria for amnestic mild cognitive impairment (Ages 60 - 85) | 2028 |
| MIND Foods and Aerobic Training in Black Adults with HTN: An ADRD Prevention Pilot RCT (MAT) | MIND Foods and Aerobic Training in Black Adults With HTN (MAT) | Daniel Clark, Indiana University-Purdue University Indianapolis | Mediterranean-Dash Intervention for Neurodgenerative Delay (MIND) and aerobic training (MAT) | Non-Hispanic black adults with hypertension (Ages 40 - 64) | 2027 |
| Behavioral Interventions for the Treatment of Early Onset Alzheimer's Disease | Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study (LITES) | Dustin Hammers, Indiana University-Purdue University Indianapolis | To conduct behavioral interventions for the management of patients with early-onset Alzheimer’s disease | Adults with a Clinical Dementia Rating scale of 0.5 to 1.0 at the time of enrollment (Ages 40 - 64) | 2028 |
| Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults | Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults | David Clark, University of Florida | Brain electrical stimulation intervention to improve walking performance and executive function in older adults with cognitive decline | Older adults with age-related cognitive decline (Ages 65 – 89) | 2027 |
| A Multi-modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors | A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors | Maya Elias, University of Washington | Daily 30-minute cognitive training sessions and/or sleep promotion intervention to improve cognitive function and sleep | Older adults with no diagnosis of dementia and an intensive care unit stay of 24+ hours (Ages 60+) | 2027 |
| Midwest Roybal Center for Health Promotion and Translation (Pilot) | Piloting the IPROACTIF Program to Preserve Functioning and Prevent Cognitive Decline | Mansha Mirza, University of Illinois at Chicago | IPROACTIF is an occupational therapist-delivered primary care intervention for aging and chronic disease management | Community-dwelling adults (Ages 55+) | 2029 |
| Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults | Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergames Telerehabilitation Study) | Tom Plocher, Moai Technologies LLC | Combination of virtual reality cognitive training combined with aerobic cycling to improve cognition and aerobic fitness to prevent Alzheimer's disease | Older adults with subjective cognitive decline (Ages 65+) | 2026 |
| Digital Integrated Behavioral Treatment for Comorbid Obesity and Depression Among Racial and Ethnic Adults Age 50 and Older (IGNITE) | Digital Integrated Behavioral Treatment for Comorbid Obesity and Depression Among Racial and Ethnic Adults Age 50 and Older (IGNITE) | Jun Ma, University of Illinois at Chicago | Digital behavioral intervention for racial and ethnic minorities that combines a virtual coaching concept for depression management and a video-based weight loss program to target comorbid depression and obesity | Adults with depression and obesity who self-identify as racial or ethnic minorities (Ages 50-74) | 2029 |
| Community-Based Brain Health Program to Address Dementia Risk (C-BBHP) | Community-Based Brain Health Program to Address Dementia Risk (C-BBHP) | Thomas Van Vleet, Posit Science Corporation | An innovative multimodal brain health program to improve cognitive function and functional abilities | Individuals at risk for Alzheimer's disease and related dementias | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Multicultural Healthy Diet to Reduce Cognitive Decline & Alzheimer's Disease Risk | Multicultural Healthy Diet to Reduce Cognitive Decline (MHD) | Yasmin Mossavar-Rahmani, Albert Einstein College of Medicine | An anti-inflammatory, multicultural health diet (MHD) to improve cognitive function in a culturally diverse population of adults | Adults (Ages 40 - 65) | 2025 |
| Validation and Mechanistic Interrogation of Metabolism Targeting for AD | Therapeutic Diets in Alzheimer's Disease (TDAD) | Russell Swerdlow, University of Kansas Medical Center | Ketogenic diet (KD) to test whether manipulating brain energy metabolism through the KD will benefit individuals with Alzheimer's disease | People with Alzheimer's disease (Ages 50 - 90) | 2024 |
| MIND Diet and Dementia Prevention in Ischemic Stroke Patients | Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients | Neelum Aggarwal, Rush University Medical Center | Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND), to test impact on cognition and brain biomarkers related to dementia in patients who are recovering from acute ischemic stroke | Individuals who have suffered acute stroke (Ages 60 - 80) | 2026 |
| The Impact of Weight Loss on Alzheimer's Disease Risk in Adults with Down Syndrome | Brain Outcomes With Lifestyle Change in Down Syndrome (BOLD) | Lauren Ptomey, University of Kansas Medical Center | Dietary intervention to determine if weight loss or changes can help prevent of delay adults with Down syndrome from developing Alzheimer's disease | Adults with Down syndrome and a body mass index (BMI) of 25 to 45 (Ages 18 - 64) | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Mechanisms of Adherence to Light Intensity Physical Activity to Prevent Alzheimer's Disease and Related Dementias | Daily Goal Setting to Increase Everyday Physical Activity and Promote Cognitive Health in Midlife | Jonathan Hakun, Penn State Health Milton S. Hershey Medical Center | Adaptive Step Goals with Interim Goal Setting: participants receive daily step goals, self-monitoring, and interim goal setting on study smart phone to promote increased goal maintenance | Middle-aged adults with increased risk for Alzheimer's disease and related dementia due to obesity | 2027 |
| Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE) | Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE) | Robert Newton, Louisiana State University Pennington Biomedical Research Center | Aerobic exercise & strength training programs to promote cognitive function in older African American adults | African American adults (Ages 65 - 85) | 2025 |
| FitMi AD: A Safe and Motivating Computer-guided Exercise System for Individuals with MCI or Mild Dementia Due to Alzheimer's Disease | FitMi AD Home Therapy for Individuals With MCI or Mild Dementia Due to Alzheimer's Disease | Daniel Zondervan, Flint Rehabilitation Devices (FlintRehab) | FitMi AD system, a wireless, sensorized at-home exercise device | Individuals with mild cognitive impairment or mild dementia | 2025 |
| Goal Setting to Promote Physical Activity Adherence in Midlife to Reduce Risk of Alzheimer's Disease and Related-Dementias: A Randomized Mechanistic Proof-of-Concept Trial | Goal Setting to Promote Physical Activity Adherence | Molly Maxfield, Arizona State University | The intervention is a Physical Activity (PA) Goal Setting Technique | Adults with BMI of 30 kg/m2 or greater (Ages 45 - 65) | 2024 |
| Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults | Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment | Fuzhong Li, Oregon Research Institute | Tai Ji Quan (martial arts practice) intervention to slow cognitive decline in older adults with mild cognitive impairment | People with Amnestic Mild Cognitive Impairment (Ages 65+) | 2025 |
| Partnered Rhythmic Rehabilitation for Enhanced Motor-Cognition in Prodromal Alzheimer's Disease | Partnered Rhythmic Rehabilitation in Prodromal Alzheimer's Disease | Madeleine Hackney, Emory University | Partnered Rhythmic Rehabilitation, an intervention that simultaneously targets cardiovascular, social and motor-cognitive domains, to improve motor-cognitive function, and neuronal, vascular and inflammatory intermediaries | Adults with prodromal Alzheimer's disease (Ages 50 - 80) | 2025 |
| The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults with Down Syndrome | The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome | Lauren Ptomey, University of Kansas Medical Center | Moderate-to-vigorous physical activity in adults with down syndrome to prevent Alzheimer's disease | Adults with down syndrome (Ages 18+) | 2025 |
| Modulation Effects of Baduanjin Mind-body Exercise on Subjective Cognitive Decline | Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline (BDJ) | Jian Kong, Massachusetts General Hospital | Baduanjin (BDJ), a mind-body exercise to reduce cognitive decline | Adults (Ages 50 - 80) | 2025 |
| A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos | A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos | G. Adriana Perez, University of Pennsylvania | "Tiempo Juntos para la Salud," a multilevel intervention for Latino adults with mild cognitive impairment that includes empowerment education for behavior change and individual motivation, building support network, and promoting community resources for safe walking to reduce inactivity | Spanish language dominant Latino adults with mild cognitive impairment (Ages 55+) | 2024 |
| Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease | Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease (AEROBIC) | Jill Morris, University of Kansas Medical Center | Exercise intervention to characterize the brain metabolic response to different exercise intensity levels and measure changes in cognition | People with Alzheimer's Disease (Ages 60+) | 2025 |
| Yoga, Aerobic and Stretching Exercise Effects on Neurocognitive Performance: A Randomized Controlled Trial | Yoga, Aerobic and Stretching Exercise Effects on Neurocognition | Neha Gothe, Northeastern University | Yoga training and aerobic exercise programs to test effects on cognitive functions, neural activity and structure, and physiological parameters | Adults with normal cognition (Ages 55 - 79) | 2025 |
| CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimer's Disease | CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease) (CYCLE AD) | Stephen Rao, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University | Indoor Cycling (high intensity; 60-90% of heart rate reserve) to slow or delay disease onset | Healthy elders at genetic risk for Alzheimer's disease; APOE e4 carriers (Ages 65 - 80) | 2025 |
| Determinants of Individual Differences in the Efficacy of Aerobic Exercise to Improve Brain Health and Reduce Alzheimer Disease Risk in Older African Americans | Exercise to Improve Brain Health in Older African Americans | Mark Gluck, Rutgers University Newark | Cardio Dance Fitness (CDF) intervention, and a Strength, Flexibility, & Balance intervention | Sedentary older African Americans (Ages 60+) | 2027 |
| Reducing African Americans Alzheimer's Disease Risk Through Exercise-MCI Cohort (RAATE-MCI) | Reducing African American's Alzheimer's Risk Through Exercise-Mild Cognitive Impairment (RAATE-MCI) (RAATE-MCI) | Robert Newton, Louisiana State University Pennington Biomedical Research Center | Exercise intervention to reduce risk in African Americans with Mild Cognitive Impairment | African Americans with mild cognitive impairment (Ages 65 - 85) | 2026 |
| Differential Effects of Exercise Modality on Cognition and Brain in Older Adults | Combined Exercise Trial (COMET) | Eric Vidoni, University of Kansas Medical Center | Aerobic and resistance exercise programs, to test combined and independent effects on cognitive, neural, and physical function | Healthy individuals (Ages 65 - 80) | 2026 |
| Establishing the Optimal Frequency of Dance Movement for Neurocognitive and Physical Outcomes in People at Risk of Alzheimer's Disease | Effects of Dance and Music Appreciation on Brain Health and Fitness in People at Risk for Alzheimer's Disease (IGROOVE) | Christina Hugenschmidt, Wake Forest University | Dance movement and music appreciation classes to improve cardiorespiratory fitness and cognition | Adults at risk for Alzheimer's disease due to subjective cognitive decline (Ages 65+) | 2027 |
| Influence of Exercise Training and Intensity on Cerebral Blood Flow Regulation and Cognitive Function in Mid-Life Adults With Cardiovascular Disease | Cardiac Rehab and Cerebral Blood Flow Study | Jenna-Lee Taylor, Mayo Clinic Rochester | Exercise intervention, comparing effects of High Intensity Interval Training (HIIT) vs. Medium Intensity Continuous Training (MICT) on cognitive function | Mid-life adults with cardiovascular disease | 2025 |
| Development of a Personalized Intervention to Motivate Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease | Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease | Laura Korthauer, Rhode Island Hospital | A 24-session healthy living education program, with enhanced content about health beliefs and mechanisms of behavior change | Cognitively healthy/normal adults with at least two Alzheimer's disease risk factors (Ages 45 - 69) | 2025 |
| Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity (EXEC-study) | Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity (EXEC) | Ulf Bronas, Columbia University | Home-based walking program to improve cognitive function in patients with co-morbid chronic kidney disease and mild cognitive impairment | Older adults with mild cognitive impairment and chronic kidney disease | 2027 |
| Dual-Task Training Exercise to Reduce Falls in Older Adults with Mild Cognitive Impairment | A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment | Fuzhong Li, Oregon Research Institute | A three-arm, single-blind, randomized controlled trial comparing efficacy of the two tai ji quan fall prevention interventions (Dual-TJQMBB, standard TJQMBB) relative to a stretching control for reducing the incidence of falls among older adults with mild cognitive impairment | Adults with mild cognitive impairment (Ages 65+) | 2028 |
| TeleExergame: An Interactive Tele-Rehabilitation Platform for Improving Motor Function in Older Adults with Cognitive Deficit | Remote Game-based Exercise Program for Cognitive and Motor Function Improvement | Bijan Najafi, BioSensics | A tele-exercise system that allows a qualified therapist to remotely supervise and interact with the patient during goal-oriented game-like and low risk exercise tasks that have been designed to improve balance and cognition | Individuals with Mild Cognitive Impairment and/or mild dementia | 2025 |
| Natives Engaged in Alzheimer's Research | Natives Engaged in Alzheimer's Research - 'Ike Kupuna (NEAR) | Joseph Kaholokula, Washington State University | A tailored Hula dance program to prevent or slow cognitive decline | Older Native Hawaiians Pacific Islanders with uncontrolled hypertension (Ages 55+) | 2026 |
| Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease | Lactate for Energy and Neurocognition (LEAN) | Jill Morris, University of Kansas Medical Center | Aerobic exercise and lactate infusions to understand changes in brain glucose metabolism and promote cognition | Cognitively normal people and people with Alzheimer's disease (Ages 60 - 90) | 2025 |
| Precision Medicine in Alzheimer’s Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-fitness Responses | A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses (SMART) | Fang Yu, Arizona State University | Aerobic exercise program to improve cognition and memory | People with mild Alzheimer’s disease (Ages 65+) | 2028 |
| Midwest Roybal Center for Health Promotion and Translation (Pilot) | Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis | Peixuan Zheng, University of Illinois at Chicago | Remotely-delivered aerobic and resistance exercise training to improving cognitive and physical function | Adults diagnosed with multiple sclerosis who have cognitive and walking impairment (Ages 50+) | 2029 |
| Boston Roybal Center for Active Lifestyle Interventions: An Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease (Pilot) | Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease (HABS) | Maiya Geddes, The Douglas Hospital Research Centre - McGill University | The Intergenerational Social Motivation Behavioral Intervention is a technology-based platform to enhance physical activity in older adults at risk for Alzheimer’s disease | Cognitively normal older adults with a first-degree family history of Alzheimer's disease (Ages 60+) | 2025 |
| mHealth-facilitated Physical Activity Toward Health (mPATH) for Cognitive Function and Sleep in Low-income Older Adults | mPATH for Low-income Older Adults | Junxin Li, Johns Hopkins Bayview Medical Center | Personalized physical activity intervention to improve cognition and sleep | Sedentary low-income older adults with sleep difficulties (Ages 65+) | 2028 |
| Midwest Roybal Center for Health Promotion and Translation (Pilot) | We Walk Plus Study for Older Adults With Intellectual Disabilities | Kueifang Hsieh, University of Illinois at Chicago | We Walk Plus intervention to promote physical activity and improve cognition for older adults with intellectual disabilities | Older adults with intellectual disabilities | 2029 |
| A Stage 1 Pilot Test for Feasibility and Efficacy of a Multi-level Intervention to Increase Physical Activity in Adults with Intellectual Disability: Step it Up+ | A Stage 1 Pilot Test for Feasibility and Efficacy of a Multi-level Intervention to Increase Physical Activity in Adults with Intellectual Disability: Step it Up+ | Brianne Tomaszewski, University of North Carolina at Chapel Hill | Fitness classes and coaching for persons with intellectual disabilities to increase physical activity | People with intellectual disabilities and no clinically elevated symptoms of Alzheimer's disease or related dementias (Ages 18+) | 2028 |
| Developing of a Computer-based Multimodal Mind and Body Approach for Mild Cognitive Decline | Developing of a Computer-based Multimodal Mind and Body Approach for Mild Cognitive Decline | Jian Kong, Brain Thrive Technology LLC | Digital self-directed multimodal mind and body approach intervention that integrates Baduanjin, acupressure, and relaxation to improve the cognitive function for mild cognitive impairment | Individuals with mild cognitive impairment (Ages 55+) | 2025 |
| Examining the Effect of High-intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living with HIV (HEALTH-Cog) | Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV (HEALTH-COG) | Pariya Wheeler, University of Alabama at Birmingham | Physical activity (High-intensity interval training versus continuous moderate exercise) and coaching interventions (psychotherapy, lifestyle counseling) to test the effects on cognitive function. | People living with HIV who are stable on HIV antiretroviral therapy (Ages 50+) | 2028 |
| Exercise Adherence and Cognitive Decline: Engaging with the Black Community to Develop and Test a Goal Setting and Exercise Intensity Intervention | Exercise Adherence and Cognitive Decline: Engaging with the Black Community to Develop and Test a Goal-setting and Exercise Intensity Intervention | Angela Bryan, University of Colorado Anschutz Medical Campus | Moderate to vigorous physical activity intervention with goal setting that aims to target biomarkers associated with cognitive decline | Middle aged and older adults (Ages 45+) | 2025 |
| Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging Among Mid-life Adults | Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging (GETActiveHIT) | Laura Martin, University of Kansas Medical Center | The application will develop and refine guided imagery exercise and test whether it increases adherence to exercise among mid-life adults | Older adults able to participate in high-intensity interval training (HIIT) exercise (Ages 65 - 85) | 2027 |
| Locomotion Adaptation Deficits in Older Adults with Mild Cognitive Impairment and Alzheimer's Disease | Locomotion Adaptation Deficits in Older Adults with Mild Cognitive Impairment and Alzheimer's Disease | Trisha Kesar, Emory University | Walking intervention to improve cognition and mobility | Adults with or without mild cognitive impairment or Alzheimer's disease diagnosis (Ages 50 - 90) | 2025 |
| Unraveling the Mechanisms of a Novel Music Intervention for Physical Activity Promotion in Older Adults | Inspiring Seniors Toward Exercise Promotion (iSTEP) | Jennifer Etnier, University of North Carolina at Greensboro | Rhythmic Auditory Stimulation that promotes physical activity behavior change in low-active older adults | Older adults (Ages 65+) | 2025 |
| De Pié y a Movernos Study: Promoting Physical Activity in Older Latinx Adults | Promoting Physical Activity in Older Hispanic/Latino(a) Adults | Dori Rosenberg, Kaiser Foundation Hospitals - Washington | Culturally adapted intervention using goal setting to reduce sedentary time and gradually increase moderate to vigorous physical activity (MVPA) in older Latinx adults | Middle-aged and older Latinx adults (Ages 55 - 89) | 2027 |
| A Pilot Trial of High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Older Adults with HIV | High-intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults with HIV | Raymond Jones, University of Alabama at Birmingham | High Impact Interval Training (HIIT) interventions for improvement of arterial stiffness and cognition in older adults with HIV | Sixty older adults living with HIV and neurocognitive disorder (Ages 50+) | 2028 |
| Arizona State University Roybal Center for Older Adults Living Alone with Cognitive Decline: Technology-Enabled Behavioral and Lifestyle Change to Delay Alzheimers Disease and Improve Quality of Life | Increasing Physical Activity Through Social Support and Stress Resilience (I-PASS) Among Older Adults Living Alone with SCD to Lower ADRD Risk | Molly Maxfield, Arizona State University | Technology based intervention with personalized goal setting and virtual coaching for increasing physical activity, social support, and stress resilience | Older adults living alone with subjective cognitive decline (Ages 60+) | 2029 |
| Goal Setting to Promote Physical Activity Adherence in Midlife to Reduce Risk of Alzheimer's Disease and Related-Dementias: A Randomized Mechanistic Proof-of-Concept Trial | Goal Setting to Promote Physical Activity Adherence in Midlife to Reduce Risk of Alzheimer's Disease and Related-Dementias: Phase II Proof-Of-Concept Trial | Molly Maxfield, Arizona State University | The intervention is a Physical Activity (PA) Goal Setting Technique to increase PA and promote adherence to national PA guidelines | Adults with BMI of 30 kg/m2 or greater (Ages 45 - 65) | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Impact of Music Improvisation Training on Brain Function and Cognition Among Older Adults | Impact of Music Improvisation Training on Brain Function and Cognition Among Older Adults (Aim 3) | Julene Johnson, University of California San Francisco | A music improvisation intervention on self-regulation, psychosocial function, and cognitive engagement to promote cognitive health and well-being | Older adults with and without mild cognitive impairment (Ages 60+) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Adaptive Neuromodulation of Working Memory Networks in Aging and Dementia | Neuromodulation of Memory in Aging (TMS-AD) | Simon Davis, Duke University | Closed-loop transcranial magnetic stimulation (TMS) to establish parameters that can reliably control brain states during normal memory functioning in healthy aging and mild cognitive impairment | Healthy older adults and individuals with mild cognitive impairment (Ages 60 - 75) | 2027 |
| Gamma-Music Based Intervention for Mild Alzheimer's Disease | Gamma-Music Based Intervention for Mild Alzheimer's Disease (NUGammaMBI) | Psyche Loui, Northeastern University | Non-invasive gamma-frequency (40 Hz) light-flickering and auditory tone-stimulation | Participants with mild Alzheimer’s disease (Ages 55 - 90) | 2027 |
| Individualized Closed-Loop Neuromodulation Therapy for Alzheimer's Disease | Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease | Joan Camprodon, Massachusetts General Hospital | Closed-loop transcranial Alternating Current Stimulation (tACS) at 40 Hz to modulate brain oscillations and cognition, as an individualized and potential disease-modifying precision therapy for Alzheimer's disease | Participants with Alzheimer's disease (Ages 50 - 80) | 2025 |
| Treating Mild Cognitive Impairment with Transcranial Direct Current Stimulation | Stimulation to Improve Memory (STIM) | Benjamin Hampstead, University of Michigan | Transcranial direct current stimulation (tDCS) to treat mild cognitive impairment | People with mild cognitive impairment (Ages 65+) | 2025 |
| Treating Mild Cognitive Impairment with Transcranial Direct Current Stimulation | STIM+: PET Biomarker Education & Disclosure (STIM+) | Benjamin Hampstead, University of Michigan | Transcranial direct current stimulation | Older adults with mild cognitive impairment | 2025 |
| Treating Primary Progressive Aphasia And Elucidating Neurodegeneration In the Language Network Using Transcranial Direct Current Stimulation | Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS | Roy Hamilton, University of Pennsylvania | High definition transcranial direct stimulation (tDCS) of the left frontal lobe with the goal of developing a potential treatment for primary progressive aphasia (PPA) | Adults with either nonfluent/agrammatic primary progressive aphasia (PPA) or logopenic variant PPA (Ages 45 - 80) | 2025 |
| Revitalizing Cognition in Older Adults at Risk for Alzheimer's Disease with Near-Infrared Photobiomodulation | The Revitalize Study in Older Adults at Risk for Alzheimer's Disease | Dawn Bowers, University of Florida | Infrared stimulation to assess improvements in cognition function and network connectivity | Older adults with subjective cognitive complains and family history of Alzheimer's disease (Ages 65 - 89) | 2025 |
| Enhancement of Hippocampal Plasticity Using Repetitive Transcranial Magnetic Stimulation | Enhancement of Hippocampal Plasticity Using Repetitive Transcranial Magnetic Stimulation | Ying-Hui Chou, University of Arizona | Repetitive Transcranial Magnetic Stimulation (rTMS) in hippocampus to determine its therapeutic effect on memory function and brain plasticity | People with Amnestic Mild Cognitive Impairment (Ages 50 - 80) | 2025 |
| Non-Invasive Home Neurostimulation for Mild to Moderate Alzheimer's Disease: Double-Blind, Sham Controlled Randomized Clinical Trial | NeurostImulation for Cognitive Enhancement in Alzheimer's Disease (NICE-AD) | Joe Verghese, Albert Einstein College of Medicine | Transcranial direct current neurostimulation (tDCS) at home intervention to improve cognitive performance and symptoms in patients with mild to moderate Alzheimer’s Disease | People with Alzheimer's disease (Ages 60+) | 2025 |
| Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD) | Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD) | Dan Iosifescu, New York University School of Medicine | Transcranial Photobiomodulation (t-PBM), which penetrates robustly into the cerebral cortex, stimulating the mitochondrial respiratory chain, and significantly increasing cerebral blood flow, to improve cognitive deficits | People with Amnestic Mild Cognitive Impairment (Ages 65 - 85) | 2025 |
| Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment | Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment | Nanthia Suthana, University of California Los Angeles | Theta burst transcranial magnetic stimulation, a non-invasive neuromodulation method applied to brain areas that are functionally connected to the hippocampus in order to improve/restore memory function | People with Amnestic Mild Cognitive Impairment (Ages 60 - 90) | 2025 |
| Transcranial Direct Current Stimulation in Typical and Atypical Alzheimer's Disease | Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease | Kyrana Tsapkini, Johns Hopkins Bayview Medical Center | Transcranial direct current neurostimulation (tDCS) to improve clinical symptoms of mild cognitive impairment | People with probable Alzheimer's disease (Ages 50+) | 2025 |
| The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance | The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance (WALLe) | Heidi Jacobs, Massachusetts General Hospital | Transcutaneous vagus nerve stimulation (tVNS) to improve cognitive function | At-risk older adults (Ages 60 - 85) | 2026 |
| Targeting Language-Specific and Executive-Control Networks with Transcranial Direct Current Stimulation in Aphasic AD | Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA | Kyrana Tsapkini, Johns Hopkins Bayview Medical Center | Transcranial direct current stimulation (tDCS) applied to brain networks that underlie several language-specific vs. executive cognitive functions to maximize the benefits of tDCS in the treatment of neurodegenerative disease | Individuals with primary progressive aphasia (Ages 50 - 80) | 2027 |
| The Power of 40 Hz Sound/Music for Older Adults with Mild Cognitive Impairment | Sound and Music for Mild Cognitive Impairment | Junxin Li, Johns Hopkins Bayview Medical Center | Feasibility and preliminary efficacy of 40 Hz music (Condition A), 40 Hz sound (Condition B) and preferred music (Condition C) on neural gamma activity and cognitive function in community-dwelling older adults with amnestic mild cognitive impairment | Older adults with amnestic MCI (65+ years of age) | 2025 |
| Multifocal Transcranial Current Stimulation for Cognitive and Motor Dysfunction in Dementia | Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia (ACDCStim) | Alvaro Pascual-Leone, Hebrew SeniorLife and Hebrew Rehabilitation Center | Transcranial alternating current stimulation targeting the left angular gyrus (tACS) at gamma frequency and transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex | Older adults with mild dementia (Ages 55+) | 2027 |
| Phase II Clinical Trial of Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia | Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia | Kyrana Tsapkini, University of Pennsylvania | Transcranial direct current stimulation (tDCS) therapy in primary progressive aphasia (PPA) | Older adults with primary progressive aphasia (Ages 50 - 80) | 2027 |
| Accelerating Cognitive Gains from Digital Meditation with Noninvasive Brain Stimulation: A Pilot Study in MCI | Accelerating Cognitive Gains From Digital Interventions with Noninvasive Brain Stimulation | David Ziegler, University of California San Francisco | Closed-loop digital meditation (MediTrain) and transcranial alternating current stimulation (tACS) to improve cognition and wellbeing in adults with mild cognitive impairment | Mild cognitive impairment (Ages 60 - 85) | 2025 |
| Modulation of Hippocampal Circuitry and Memory Function with Focused Ultrasound in Amnestic MCI | Modulation of Hippocampal Circuitry and Memory Function With Focused Ultrasound in Amnestic MCI (LIFUP-MCI) | Susan Bookheimer, University of California Los Angeles | Low intensity focused ultrasound pulsation (LIFUP) to improve learning and memory | Adults (Ages 75+) | 2026 |
| Multimodal Musical Stimulation for Healthy Neurocognitive Aging | Multimodal Musical Stimulation for Healthy Neurocognitive Aging (Multimodal) | Psyche Loui, Northeastern University | Gamma frequency stimulation is administered via lights, and tuned to user-defined music; participants receive the intervention by listening to music while watching lights | Neurologically healthy older and younger adults | 2025 |
| Transcranial Magnetic Stimulation for MCI: A Phase II Dose-response Study | Transcranial Magnetic Stimulation for MCI (PUSH2) | Andreana Benitez, Medical University of South Carolina | Intermittent theta-burst repetitive transcranial magnetic stimulation (iTBS-rTMS) to improve cognitive function and depression | People with Mild Cognitive Impairment and Major Depressive Disorder (Ages 60 – 85) | 2028 |
| Neuromodulation of Brain Network Function in Preclinical and Prodromal Alzheimer's Disease | Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease | Alexandra Touroutoglou, Massachusetts General Hospital | Repetitive transcranial magnetic stimulation (rTMS) to improve brain function and improve symptoms in Alzheimer's disease | Amyloid-positive people with and without amnestic mild cognitive impairment (Ages 65 – 85) | 2025 |
| Personalized Synchronization of Cortical Rhythms to Improve Memory in Alzheimer's Disease | Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation | Robert Reinhart, Boston University | Personalized non-invasive brain stimulation to improve memory | Cognitively healthy older adults, persons with mild cognitive impairment, or persons with Alzheimer's disease (Ages 50 - 100) | 2028 |
| Long-term home-based transcranial electrical stimulation for cognitive and motor function in older adults with an increased risk of dementia: a randomized controlled trial | Long-term Home-based Transcranial Electrical Stimulation for Cognitive and Motor Function in Older Adults with an Increased Risk of Dementia: A Randomized Controlled Trial | Bradley Manor, Hebrew SeniorLife / Hebrew Rehabilitation Center | Individually-tailored transcranial direct current stimulation to induce sustained improvements in cognitive and motor function | Older men and women with motoric cognitive risk (Ages 65-90) | 2029 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Light, Metabolic Syndrome and Alzheimer’s Disease: A Non-Pharmacological Approach | Light and the Effect on Metabolic Syndrome and Alzheimer's Disease | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | 8-week Tailored Lighting intervention (TLI). The active TLI will provide high circadian stimulation during the day produced by light sources that provide moderate light levels of spectra that are tuned to the sensitivity of the circadian system | Older adults with mild to moderate Alzheimer's Disease diagnosis and Type 2 diabetes (Ages 55+) | 2025 |
| Primary Prevention of Alzheimer's Disease: Examining the Effects of Cognitive Behavioral Therapy on Cognitive Function and Amyloid-beta in Older Adults with Symptoms of Insomnia | SIESTA: Sleep Intervention to Enhance Cognitive Status and Reduce Beta Amyloid | Catherine Siengsukon, University of Kansas Medical Center | CBT-I, cognitive behavioral therapy for insomnia | People with difficulty falling asleep, maintaining sleep, or waking up too early at least 3 nights per week for the past 3 months (Ages 60 - 85) | 2025 |
| Personalized OSA Treatment and Effects on AD Biomarkers and Cognition Among Blacks | Personalized Obstructive Sleep Apnea Treatment and Effects on Alzheimer's Disease Biomarkers and Cognition Among Blacks (PRAISE) | Girardin Jean-Louis, University of Miami School of Medicine | Personalized OSA Treatment Adherence Model (PRAISE), a personalized obstructive sleep apnea (OSA) treatment adherence model; participants will be exposed to either personalized OSA videos (intervention arm) or standard online videos (control arm) | Older black adults newly diagnosed with obstructive sleep apnea (Ages 60 – 85) | 2028 |
| The Long-Term Impact of Light Intervention on Sleep Physiology and Cognition in Mild Cognitive Impairment | The Long-term Impact of a Light Intervention on Sleep and Cognition in Mild Cognitive Impairment | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Light intervention to improve sleep and mild cognitive impairment | People with amnestic mild cognitive impairment or mild Alzheimer's disease (Ages 65+) | 2025 |
| Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease | Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease | Atul Malhotra, University of California San Diego | Supplemental oxygen and Continuous Positive Airway Pressure (CPAP) machine to determine if oxygen is a viable therapeutic strategy to improve memory | Cognitively healthy older adults (Ages 65-85) | 2025 |
| Slow-wave Sleep Enhancement in Those At-Risk for Alzheimer's Disease: Links with Memory, Excitotoxicity, and Plasma A-beta | Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease (ALPS) | Kristine Wilckens, University of Pittsburgh | Habitual slow-wave sleep enhancement to improve cognition | Older adults (Ages 65 - 85) | 2026 |
| The Use of Rhythmic Light Therapy to Entrain Gamma Oscillations and the Circadian System in Patients with Alzheimer's Disease and Related Dementias (ADRD) | Rhythmic Light Therapy for Alzheimer's Disease Patients | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Rhythmic Light Therapy to improve sleep and cognition | Older adults with mild cognitive impairment | 2027 |
| Home Sleep Therapy System for Mild Cognitive Impairment | Home Sleep Therapy for Older Adults With MCI | Don Tucker, Brain Electrophysiology Laboratory Company, Llc | Neurosom® Electric Sleep Therapy (NEST) system to allow researchers to conduct transcranial electrical stimulation (TES) studies to improve sleep in seniors with mild cognitive impairment | Adults with amnestic mild cognitive impairment (Ages 55 - 85) | 2026 |
| Internet-Based Insomnia Intervention to Prevent Cognitive Decline in Older Adults with Mild Cognitive Impairment | Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND) | Meghan Mattos, University of Virginia | Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention | Older adults with mild cognitive impairment and insomnia (Ages 65+) | 2027 |
| Light, Metabolic Syndrome And Alzheimer's Disease: A Non-Pharmacological Approach | Light, Metabolic Syndrome and Alzheimer's Disease - Aim 2 | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Tailored Lighting Intervention to improve sleep disturbances, inflammation, insulin sensitivity (Si) and glucose disposal (Sg) and cognition in patients with mild cognitive impairment or mild Alzheimer's disease and related dementias (AD/ADRD) and sleep disturbances | Adults with Alzheimer's disease and related dementias (AD/ADRD) who live in controlled environments (i.e., assisted living facilities and nursing homes) | 2025 |
| Methodology Issues in a Tailored Light Treatment for Persons with Dementia | Methodology Issues in a Tailored Light Treatment for Persons With Dementia - Aim 2 | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Light exposure treatment to investigate the effect on sleep, mood, and agitation in persons with Alzheimer's disease or related dementias living in assisted living and nursing home settings | Individuals with Alzheimer's disease or related dementias and sleep problems (Ages 65+) | 2025 |
| Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL) | The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study (ESSENTIAL) | Katie Stone, California Pacific Medical Center (Sutter Health) | Obstructive sleep apnea therapies including positive airway pressure, oral appliance therapy, and positional therapy, to promote cognitive function in older adults | Cognitively normal older adults with moderate to severe obstructive sleep apnea (Ages 55 - 75) | 2028 |
| Time Restricted Eating intervention for Alzheimers disease (TREAD) | TREAD: Time Restricted Eating Intervention for Alzheimer's Disease (TREAD) | Paula Desplats, University of California San Diego | Prolonged night fasting intervention for persons with mild cognitive impairment to promote cognitive function | Older adults with mild cognitive impairment (ages 65+) and study support persons (ages 60+) | 2026 |
| Methodology Issues in a Tailored Light Treatment for Persons with Dementia | Investigating the Impact of Duration and Amount of Light on the Circadian System Response - Aim 3 | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Light exposure treatment to investigate the effect on sleep, mood, and agitation in persons with Alzheimer's disease or related dementias living in controlled environments | Individuals with Alzheimer's disease or related dementias and sleep problems (Ages 60+) | 2025 |
| Methodology Issues in a Tailored Light Treatment for Persons with Dementia | Methodology Issues in a Tailored Light Treatment for Persons with Dementia - Aim 1 | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Light treatment designed to promote better sleep, cognition, mood and behavior in people living with Alzheimer's disease or related dementias | Individuals with Alzheimer's disease or related dementias and sleep problems (Ages 65+) | 2025 |
| Leveraging social networks to improve sleep and mindfulness among older adults in low-income housing | Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Low-income Housing | Rebecca Robbins, Brigham & Women's Hospital | A sleep, mindfulness, and sleep disorders education intervention developed with the aim of improving sleep, quality of life, and cognitive function among older adults | Cognitively unimpaired older adults in low-income housing (Ages 55+) | 2027 |
| Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples with Implications for Alzheimer’s Disease Risk | Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples with Implications for Alzheimer’s Disease Risk | Kelly Baron, University of Utah | A telehealth intervention developed to promote positive airway pressure adherence and sleep health | Patients diagnosed with Obstructive Sleep Apnea and their partners (ages 35+) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Enhancing Social Engagement through Online Gameplay for Older Adults with and without Mild Cognitive Impairment | Enhancing Social Engagement through Gameplay in Older Adults | Dillon Myers, Potluck, LLC | OneClick, an online social engagement platform, to benefit health outcomes affected by social engagement (survival, onset of dementia) | Adults with mild cognitive impairment | 2026 |
| Center for Research and Education on Aging and Technology Enhancement - CREATE | Virtual Reality to Support Aging Adults | Sara Czaja, Joan and Sanford I Weill Medical College of Cornell University | Virtual reality program for social activity and cognitive engagement | Community dwelling older adults with mild cognitive impairment | 2027 |
| Center for Research and Education on Aging and Technology Enhancement - CREATE | A Software System to Support Aging Adults With A Cognitive Impairment | Sara Czaja, Joan and Sanford I Weill Medical College of Cornell University | Intelligent Adaptive System, an innovative intelligent adaptive software package aimed at providing social and cognitive support to older adults with mild cognitive impairment | Cognitively diverse older adults | 2027 |
| Arizona State University Roybal Center for Older Adults Living Alone with Cognitive Decline: Technology-Enabled Behavioral and Lifestyle Change to Delay Alzheimers Disease and Improve Quality of Life | Early-Stage Partner in Care-Living Alone (EPIC-LA) | Abigail Gómez-Morales, Arizona State University | Group-based intervention to create an environment to learn about memory changes, clarify personal care, and enhance communication and coping skills | Community-dwelling adults living alone with early Alzheimer’s disease or related dementias | 2029 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Association of Perceived Stress and Cognition | PRogram to Improve Stress-levels and Enhance Memory (PRISEM) | Ambar Kulshreshtha, Emory University | A web-based multidisciplinary stress reduction program to examine the association of stress and cognition, role of cardiovascular disease risk factors, and related health disparities | African Americans and White adults with mild cognitive impairment | 2025 |
| Optimizing a Closed-loop Digital Intervention for Remediating Cognitive Decline and Reducing Stress in Older Adults | Enhancing Attention and Wellbeing Using Digital Therapeutics | David Ziegler, University of California San Francisco | MediTrain, a digital meditation intervention to reduce cognitive decline and emotional stress | Older adults | 2027 |
| PATH-Pain: A Primary Care-Based Psychosocial Intervention to Improve Cognitive and Depression Outcomes in Older Adults with MCI and Early Stage AD | A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD (PATH-Pain) | Dimitris Kiosses, Joan and Sanford I Weill Medical College of Cornell University | Problem Adaptation Therapy for Pain (PATH-Pain) primary-care based psychosocial intervention designed to reduce stress | Adults with mild cognitive impairment or early stage Alzheimer's disease (Ages 60+) | 2026 |
| Targeting Cognitive Function and Interoceptive Awareness to Improve Self-management in Patients with Co-morbid Heart Failure and Cognitive Impairment | Mind Your Heart-II (MYH-II) | Elena Salmoirago-Blotcher, Miriam Hospital | A mindfulness training intervention to improve cognitive function in patients with co-morbid heart failure and cognitive impairment | Individuals with mild cognitive impairment and heart failure | 2027 |
| A Pilot Study of the Impact of Personalized Digital Meditation on Improving Cognition and Sleep and Reducing Stress in MCI | Studying the Effects of Digital Interventions on Cognition, Wellbeing, Stress, and Sleep in Older Adults (MediDream) | David Ziegler, University of California San Francisco | Closed-loop digital meditation to improve cognitive function, sleep, and stress in older adults | Older adults with mild cognitive impairment and cognitively normal older adults (Ages 60 - 85) | 2025 |
| My Healthy Brain: A Mindfulness-Based Lifestyle Intervention to Modify Early Risk of Dementia in Older Adults | Brain Health Program for Older Adults With Subjective Cognitive Decline | Ryan Mace, Massachusetts General Hospital | My Healthy Brain (MHB) teaches education, mindfulness skills, and behavior change principles. All MHB skills were adapted to account for commonly reported Subjective Cognitive Decline symptoms (e.g., forgetfulness) and co-morbid psychological barriers (e.g., low motivation) that can interfere with lifestyle behavior change. | Medical providers and older adults at risk for Alzheimer's disease and related dementia (Ages 60+) | 2027 |
| Development of an Online Mindfulness Training Program for Adults with Subjective Cognitive Decline | Development of an Online Mindfulness Training Program for Adults with Subjective Cognitive Decline | Ruchika Prakash, Ohio State University | An online, asynchronous intervention where participants will be guided through didactics on mindfulness to reduce mind-wandering, strength neural circuitry, and slow the rate of accumulation of Alzheimer's disease biomarkers | Adults with subjective cognitive decline (Ages 50+) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Addressing the Chronic Pain-Early Cognitive Decline Comorbidity Among Older Adults; The Active Brains Study | Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain | Ana-Maria Vranceanu, Massachusetts General Hospital | Two symptom management programs, Active Brains-Digital (AB-D) and Health Enhancement Program (HEP), to assess how each program may help in improving multimodal physical, cognitive, and emotional function | Older adults with nonmalignant chronic pain for more than 3 months and early cognitive decline (Ages 60+) | 2027 |
| Long-Term Effects of Hearing Intervention on Brain Health in the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) Randomized Study | ACHIEVE Brain Health Follow-Up Study (ACHIEVE-BHFU) | Frank Lin, Johns Hopkins Bayview Medical Center | Follow up of ACHIEVE cohort for an additional three years to determine the long- term effects of hearing intervention (i.e., participants randomized to hearing intervention at Year 0) versus successful aging/delayed hearing intervention control (i.e., participants randomized to successful aging intervention at Year 0 and offered the hearing intervention after their Year 3 visit) on cognitive and brain outcomes | Older adults with mild-to-moderate hearing loss and a MMSE score greater than or equal to 23 (Ages 73 - 89) | 2027 |
| Reducing Risk of Dementia through De-prescribing (R2D2) | Reducing Risk of Dementia Through Deprescribing (R2D2) | Noll Campbell, Purdue University | Pharmacist-driven de-prescribing protocol focused only on targeted anticholinergic medications | Older adults with subjective cognitive dysfunction and at least one order for a strong anticholinergic medication in the previous 12 months (Ages 65+) | 2025 |
| Impacts of Receiving Alzheimer's Disease Genetic Risk Information Among Latinos in Northern Manhattan | Information About Alzheimer's Disease for Latinos in New York City (IDEAL) | Ruth Ottman, Columbia University | Information about risk of Alzheimer's disease given to participants based on their APOE genotypes, in addition to Latino ethnicity and family history, to assess the psychosocial and behavioral impacts | Latino or Hispanic adults (Ages 40 - 64) | 2025 |
| RETAIN: A Digital Therapeutic for Alzheimer's Risk Reduction | The Retain Your Brain Health Study (RetainYourBrain.com) | Mark McInnis, RETAIN Health, Inc. | Digital therapeutic designed to reduced risk of Alzheimer's disease | Normal healthy volunteers with a family history of Alzheimer's disease | 2025 |
| Returning Research Results that Indicate Risk of Alzheimer's Disease to Healthy Participants in Longitudinal Studies | Returning Research Results That Indicate Risk of Alzheimer's Disease Dementia to Healthy Participants in Longitudinal Studies (WeSHARE) | Sarah Hartz, Washington University in St. Louis | Returning research results to participants to measure impact on cognitive and psychosocial outcomes | Cognitively normal individuals who have had imaging studies within 18 months, APOE genotyping, and are scheduled for annual visits | 2025 |
| Enhancing Gamma Band Response to Improve Working Memory in Individuals with Mild Cognitive Impairment | Neurofeedback to Improve Working Memory in Mild Cognitive Impairment | Fiza Singh, University of California San Diego | EEG-neurofeedback (EEG-NFB) computer-based brain training program to improve working memory in individuals with amnestic mild cognitive impairment | People with Amnestic Mild Cognitive Impairment (Ages 60 - 85) | 2025 |
| Compensation Training and Lifestyle Modifications to Promote Healthy Aging in Persons at Risk for Alzheimer's Disease: A Digital Application Supported Intervention | Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention (BB2) | Sarah Tomaszewski Farias, University of California Davis | Digital Memory Notebook intervention, an interactive application used to facilitate behavioral change and enhanced motivation | People with Alzheimer's disease or mild cognitive impairment (Ages 65 - 90) | 2025 |
| ADRD Prevention Messaging to Increase Smoking Cessation Attempts in Older Adult Smokers | Motivating Change in Aging Smoker | Adrienne Johnson, University of Wisconsin - Madison | Motivation to Quit Intervention to increase motivation to quit, quit attempts, and use of evidence-based smoking treatments (EBSTs) for older adult smokers | Older adult smokers (Ages 50 - 80) | 2026 |
| Clinical Trial of Vestibular Therapy to Reduce Falls in Patients with Alzheimer's Disease | Vestibular Therapy in Alzheimer's Disease | Yuri Agrawal, University of Colorado Anschutz Medical Campus | Vestibular therapy to reduce falls and improve balance in older adults with mild to moderate Alzheimer's disease and vestibular loss | Adults with mild-moderate Alzheimer's disease & vestibular loss (Ages 60+) | 2026 |
| Intermittent Hypoxia Training: A Novel Therapy for Mild Cognitive Impairment | IHT for Mild Cognitive Impairment | Xiangrong Shi, University of North Texas Health Science Center | An intermittent-hypoxia training (IHT) program to prevent or reverse cognitive decline and neurodegeneration in mild cognitive impairment | Individuals with amnestic mild cognitive impairment | 2025 |
| Mediators and Moderators of Auditory Training | Mediators and Moderators of Auditory Training | Aaron Seitz, Northeastern University | An auditory training intervention to mitigate hearing issues that promote dementia risk | Older adults (ages 60 - 85) with no more than typical hearing loss for their age, no evidence of dementia and comparison younger adults (ages 18 - 30) with normal hearing | 2027 |
| Center for Research and Education on Aging and Technology Enhancement - CREATE | Digital Tools to Support Healthcare Decision Making | Sara Czaja, Joan and Sanford I Weill Medical College of Cornell University | Intelligent Decision Support Tool, an innovative intelligent decision tool for health decisions aims at providing health management support for older adults with and without mild cognitive impairment | Cognitively diverse older adults | 2027 |
| Early Age-Related Hearing Loss Investigation (EARHLI): A Randomized Controlled Trial to Assess Mechanisms Linking Early Age-Related Hearing Loss and Alzheimer's Disease and Related Dementia | Early Age-Related Hearing Loss Investigation (EARHLI) | Justin Golub, Columbia University | Hearing aids to prevent cognitive decline in those at risk for Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) | Older adults with early-stage age-related hearing loss (ARHL) and amnestic mild cognitive impairment (55 - 75 years of age) | 2027 |
| Effects of Resonance-Frequency Breathing on Preclinical Alzheimer’s Disease Biomarkers and Cognition | Effects of Paced Breathing on Learning and Alzheimer's Disease Biomarkers in Healthy Adults | Mara Mather, University of Southern California | Ten weeks of daily paced breathing sessions to determine whether resonance breathing improves plasma Alzheimer's disease (AD) biomarkers, identify how resonance-frequency breathing affects plasma AD biomarkers, assess whether daily resonance-frequency breathing accelerates consolidation of new learning, and compare effects in African Americans vs. European Americans | Cognitively normal African-American and European-American adults (Ages 50 - 70) | 2027 |
| Assessing the Feasibility and Acceptability of a Time Restricted Feeding Intervention Among Older Adults With Mild Cognitive Impairment | Time Restricted Eating for Metabolic and Psychological Optimization (TEMPO) | Patrick Smith, University of North Carolina at Chapel Hill | Time restricted fasting intervention to improve metabolic and cognitive health | Amnestic mild cognitive impairment (Ages 65 - 80) | 2025 |
| Remote Monitoring and Virtual Collaborative Care for Hypertension Control to Prevent Cognitive Decline | Remote Monitoring and Virtual Collaborative Care For Hypertension Control to Prevent Cognitive Decline Phase II (vCCC 2) | Jeffrey Burns, University of Kansas Medical Center | Remote blood pressure monitoring and management through a virtual Collaborative Care Clinic (vCCC) | Older adults with hypertension | 2025 |
| The Use of Rhythmic Light Therapy to Entrain Gamma Oscillations and the Circadian System in Patients with Alzheimer's Disease and Related Dementias (ADRD) | Phase 2 - Rhythmic Light Therapy for Alzheimer’s Disease | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Gamma oscillation entrainment for persons with amnestic mild cognitive impairment or mild Alzheimer's disease to improve sleep and cognition | People with amnestic mild cognitive impairment or mild Alzheimer's disease (Ages 55+) | 2027 |
| Feasibility of Improving Glycemia to Prevent Alzheimer's Disease | Feasibility of Improving Glycemia with Heat Therapy to Prevent AD (FIGHT-AD) | Jill Morris, University of Kansas Medical Center | Heat therapy to improve systemic blood glucose metabolism to reduce risk for Alzheimer's disease | Cognitively healthy people (Ages 65+) | 2028 |
| Communication Bridge: Optimizing an Evidence-based Intervention for Individuals with Primary Progressive Aphasia | Communication Bridge 3 Study (CB3) | Emily Rogalski, University of Chicago | Speech-language intervention combined with psychosocial education and counselling to improve communication participation and caregiver burden | People with primary progressive aphasia and their care partners (Ages 18+) | 2028 |
| Developing a Peer Support Intervention for Depression in SCD | Developing a Peer Support Intervention for Depression in SCD | Jin Hui Joo, Massachusetts General Hospital | An intervention to decrease depression among older adults who are also experiencing subjective cognitive decline by informing adequate care and increasing access to mental health services in the community | Adults with subthreshold depression and subjective cognitive decline (Ages 50+) and their study partners (Ages 50+) | 2026 |
| Feasibility of Tele-Singing at Home for Older Adults with Mild Cognitive Decline | Feasibility of Tele-Singing at Home for Older Adults with Mild Cognitive Decline | Linda Chao, Northern California Institute for Research and Education (NCIRE) | Online group singing intervention to help slow cognitive decline and improve quality of life in older adults with mild cognitive impairment | Older adults with mild cognitive impairment or subjective memory decline (Age 60+) | 2027 |
| ADEPT-ICU: Attenuating Depression with Internet Cognitive Behavioral Therapy (CBT) to Slow Cognitive Decline in Older Intensive Care Unit (ICU) Survivors | ADEPT-ICU: Attenuating Depression with Internet Cognitive Behavioral Therapy (CBT) to Slow Cognitive Decline in Older Intensive Care Unit (ICU) Survivors | Babar Khan, Indiana University-Purdue University Indianapolis (IUPUI) | Therapist-assisted, internet cognitive behavioral therapy intervention to reduce subjective cognitive decline in older intensive care unit survivors who have post intensive care unit depression | Older adult intensive care unit survivors with depression (Age 50+) | 2029 |
Section 4: Dementia Care and Caregiver
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Pragmatic Trial to Improve Communication for Primary Care Patients with ADRD | Improving Communication for Primary Care Patients | Jennifer Wolff, Johns Hopkins Bayview Medical Center | SHARING Choices (Sharing access to Health records, Agenda setting and RespectING Choices to Engage Families), a multicomponent communication intervention that seeks to proactively engage family members and support advance care planning (ACP) in primary care | Adults with Alzheimer's disease and related dementias (AD/ADRD) (Ages 65+) | 2025 |
| POST Facilitation for Community Dwelling Older Adults with and without Dementia | POST Facilitation for Community Dwelling Older Adults (POST-RCT) | Alexia Torke, Indiana University-Purdue University Indianapolis | Physician Orders for Scope of Treatment (POST), a virtual at-home advanced care planning (ACP) intervention to make decisions about care goals and to record preferences in writing | Frail, older community dwelling adults (Ages 65+) and their surrogate decision maker | 2025 |
| Involving Family to Improve Advance Care Planning for Primary Care Patients with ADRD | SHARE: Sharing Healthcare Wishes in Primary Care | Jennifer Wolff, Johns Hopkins Bayview Medical Center | Sharing Healthcare Wishes in Primary Care (SHARE), a multicomponent communication intervention to proactively engage family members or friends to support advance care planning in primary care | Persons with cognitive impairment (Ages 80+) and family dyads | 2025 |
| Decision Making and Implementation of Aging-in-Place/Long Term Care Plans among Older Adults | Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults | Lee Lindquist, Northwestern University | Plan Your Lifespan, a web-based decision-making and planning tool to examine the mediating/moderating factors involved in decision-making, timing of decision implementation, and goal concordance for older adults aging-in-place/long term care | Community-dwelling older adults (Ages 55+) | 2025 |
| Effectiveness of Engaging in Advance Care Planning Talks (ENACT) Group Visits Intervention in Primary Care for Older Adults with and without Alzheimer's Dementia | Effectiveness of Engaging in Advance Care Planning Talks (ENACT) Group Visits in Primary Care for Older Adults With and Without Alzheimer's Disease (ENACT) | Hillary Lum, University of Colorado Anschutz Medical Campus | ENgaging in Advance Care planning Talks (ENACT) Group Visits intervention to increase advance care planning (ACP) documentation among older adults in primary care settings, including older adults with cognitive impairment | Older adults that have at least one primary care clinic visit in the past 12 months (Ages 70+) | 2026 |
| Implementation Strategies to Promote Advance Care Planning among Persons Living with ADRD and Those with Mild Cognitive Impairment in Outpatient Primary Care Practices | A Portal-based Advance Care Planning Intervention among Community-Dwelling Persons Living with Cognitive Impairment (Portal-Voice) | Jennifer Gabbard, Wake Forest University | ACPdSmart is a dementia-specific portal-based tool for advance care planning engagement | Adults with recognized or probable mild cognitive impairment or mild dementia, yet retain decisional capacity to complete advance care planning (Ages 65+) | 2027 |
| Hybrid Efficacy/Effectiveness Trial to Promote Goals-of-Care Discussions for Patients with Alzheimer's Disease and Related Dementias and their Family Caregivers | Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers (PICSI-M) | Erin Kross, University of Washington | "Jumpstart", a one-page guide using patient-specific information to prompt and guide clinicians in goals-of-care discussions | Adults with an ICD10 code for Alzheimer's disease and related dementias (AD/ADRD) in the electronic health record (EHR) in the prior two years (Ages 55+) | 2027 |
| Meeting the Challenges of COVID-19 by Expanding the Reach of Palliative Care: Proactive Advance Care Planning with Videos for the Elderly and all Patients with Dementia | Palliative Care Educator (VIDEO-PCE) | Michael Paasche-Orlow, Tufts Medical Center | COVID-19 advance care planning (ACP) Educator-led, video-assisted palliative care intervention to improve patient-clinician communication, increase ACP documentation, and lead to more patient-centered care at the end of life | Hospitalized patients and any patient with Alzheimer's disease and related dementias, as well as proxy decision-makers (Ages 65+) | 2025 |
| Improving Primary Care Clinicians' Advance Care Planning for Alzheimer's Disease and Related Dementias | Improving Primary Care Clinicians Advance Care Planning for Alzheimer's Disease and Related Dementias | Christine Kistler, University of Pittsburgh | Toolkit with modules that include information and training on Alzheimer’s disease and related dementias education, advance care planning communication skills, and clinical implementation guidance | Physicians/ Advance Practice Providers and primary care team members | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| The PorchLight Project | The PorchLight Project | Joseph Gaugler, University of Minnesota Twin Cities | The Porchlight Project is multicomponent training delivered to volunteers and includes three established online training modules on person-centered dementia care; a four-session online training program that demonstrates to volunteers how to apply person-centered dementia care knowledge to their interactions with persons with dementia and their caregivers; and ongoing monthly coaching sessions | Family caregivers, persons with dementia, and senior volunteers | 2027 |
| The Caregiver Resource Room: Enhancing Support for Caregivers of Alzheimer's Disease and Related Dementias (ADRD) | Identifying Needs and Services for Caregivers of Persons with Dementia | Francesca Falzarano, University of Southern California | Online self-assessment and tailored referral platform to support caregivers of individuals with Alzheimer's disease and related dementia | Caregivers of individuals with Alzheimer's disease and related dementia | 2026 |
| Efficacy of the WeCareAdvisor: An Online Tool to Help Caregivers Manage Behavioral and Psychological Symptoms in Persons with Dementia | WeCareAdvisor Study for Caregivers of People Living With Dementia | Laura Gitlin, Drexel University | WeCareAdvisor, an online tool to help caregivers manage behavioral and psychological symptoms in persons with dementia | Caregivers (Ages 21+) | 2025 |
| Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers | Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers (EnACT) | Jacqueline Eaton, University of Utah | Enhancing Active Caregiver Training intervention to manage common behavioral symptoms associated with Alzheimer's disease and related dementias | Caregivers of persons living with Alzheimer's disease and related dementias | 2025 |
| Impact of Adult Day Services on Psychosocial and Physiological Measures of Stress Among African American Dementia Family Caregivers | Impact of Adult Day Service Use on Measures of Stress Among Black/African American Dementia Caregivers | Lauren Parker, Johns Hopkins Bayview Medical Center | Mechanism study to identify how adult day services influences caregiving related stressors and needs for African American caregivers of individuals with Alzheimer's disease and related dementias | African American Caregivers | 2025 |
| Using Technology to Support Care Partners for Persons with Alzheimer's Disease: Tele-STELLA | Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA (Tele-STELLA) | Allison Lindauer, Oregon Health and Science University | Telehealth intervention using education and peer support to reduce stress and behavioral symptoms for family care partners for those with Alzheimer's disease and related dementias | Rural, African American, and White care partners for those living with Alzheimer's disease and related dementias | 2026 |
| Testing Dementia Caregiver TeleCoaching to Reduce Episodes of Abuse and Neglect by Recognizing and Managing Care-Resistant Behaviors | Coaching Dementia Caregivers to Master Care-Resistant Behavior (CuRB-IT) | Rita Jablonski, University of Alabama at Birmingham | Care-Resistant Behavior Internet Training (CuRB-IT) to enhance coping skills of family caregivers and reduce elder abuse and neglect (EAN) | Caregivers for persons with Alzheimer's disease and related dementias (AD/ADRD) | 2027 |
| An Assistive-Technology Based Caregiver Training Program (CTP) to Enhance Caregiver Effectiveness, Well-being, and Quality of Life, Which Will Improve Overall Care for Individuals Living with AD/ADRD | Efficacy of Caregiver Training Program in Enhancing Caregiver and Patient Outcomes | Matthew Golden, MapHabit, Inc. | MapHabit System and Caregiver Training Program (CTP) to improve caregiver quality of life and overall patient care | Dyads, caregivers and individuals living with dementia | 2025 |
| Emergency Preparedness and Support of Caregivers of Persons with Dementia: The Disaster PrepWise Study | Emergency Preparedness for Caregivers of Persons With Dementia: Disaster PrepWise (DPW-Caregiver) | Sato Ashida, University of Iowa | Disaster PrepWise (DPW), an intervention program to enhance emergency preparedness and support networks to increase caregiver resilience and minimize distress | Caregivers of individuals with Alzheimer's disease and related dementias (AD/ADRD) | 2027 |
| Learning Skills Together: A Randomized Controlled Trial of a Complex Care Skills Intervention to Improve AD/ADRD Caregiver Self-Efficacy | Learning Skills Together Family Caregiver Complex Intervention (LST) | Kylie Meyer, Case Western Reserve University | Learning Skills Together (LST), a complex care skills intervention to improve caregiver self-efficacy | Caregivers to persons living with mid-stage Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| Roybal Center for Dementia Family Caregiver Mastery (Pilot) | Study of the Aliviado DSD Caregiving Mastery Program | Shih-Yin Lin, New York University | Aliviado DSD Caregiving Mastery Program includes Family-centered training on delirium superimposed dementia (DSD) plus an mHealth app-based care plan of DSD prevention, detection, and management tasks and tailored mobile push notification task reminders and encouragements | Family caregivers for individuals living with Alzheimer's disease and related dementias (AD/ADRD) | 2029 |
| Roybal Center for Dementia Family Caregiver Mastery (Pilot) | The Couple in Control | Kenneth Hepburn, Emory University | Couple in Control (CiC), a toolkit of communication skills and decisional strategies to help couples experiencing mild cognitive impairment cope with various challenges | Dyads of individuals diagnosed with mild cognitive impairment and their care partners | 2029 |
| The Pain Identification and Communication Toolkit: A Training Program to Support Family Caregivers of Persons with ADRD | Evaluating the Efficacy of the Pain Identification and Communication Toolkit (PICT) | Catherine Riffin, Joan and Sanford I Weill Medical College of Cornell University | Pain Identification and Communication Toolkit (PICT), a multicomponent intervention for caregivers of people with Alzheimer's disease and related dementias to provide training in observational pain assessment and coaching in effective pain communication techniques | Patients with moderate/severe Alzheimer's disease and related dementia and their caregivers | 2028 |
| Roybal Center for Dementia Family Caregiver Mastery (Pilot) | WECARE (WellnessEnhancement for Caregivers) | Alicia Hong, George Mason University | Wellness Enhance for Caregivers (WECARE) is a 7-week social media-based behavioral intervention designed for Chinese American family caregivers of persons with Alzheimer’s disease and related dementias | Chinese American family caregivers of persons with dementia | 2029 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology (Pilot) | CONFIDENCE-AI Financial Education for Caregivers (CONFIDENCE-AI) | Kylie Meyer, Case Western Reserve University | An AI-Embedded Intervention that increases caregiver resourcefulness and displaces out-of-pocket caregiving costs with community and other resources to help mitigate financial strain | Adult Latino/Hispanic family caregivers to persons living with dementia (Ages 18+) | 2025 |
| Rochester Roybal Center for Social Ties and Aging Research (Pilot) | A Cultural Adaptation of the Caregiver TLC Psychoeducational Program to Support Latino Caregivers (CUIDANDO JUNTOS) | Julian Montoro-Rodriguez, University of North Carolina at Charlotte | Latino Caregiver Thrive, Learn & Connect (TLC) is a Spanish telehealth caregiver educational and skill-building program to improve caregiver experience | Latino caregivers (Ages 45+) | 2025 |
| Roybal Center for Dementia Family Caregiver Mastery (Pilot) | Improving Care through Improv: Promoting Mastery in the Moment | Candace Kemp, Georgia State University | The intervention, “Improving Care though Improv,” involves four highly interactive weekly two-hour sessions delivered over a one-month designed to build care partner skills and improve mastery and care experiences and outcomes | Care partners of persons living with dementia | 2029 |
| Caregiver as Navigator-Developing Skills Online (CAN-DO): Developing Dementia Family Caregiver Mastery for Navigating Complex Health, Social Service, Legal, Financial, and Family Systems | Caregiver as Navigator: Develop Skills Online (CAN-DO) | Carolyn Clevenger, Emory University | Psychoeducation program that seeks to enhance caregivers’ knowledge, skills and mastery of the many tasks they perform and responsibilities they assume in assisting the person living with dementia | Individuals serving as caregivers for family members and friends living with Alzheimer’s disease and related dementias | 2028 |
| PERSEVERE in Lewy Body Dementia: A Randomized, Controlled Trial of Peer Mentor Support and Caregiver Education | PERSEVERE: Peer Mentor Support and Caregiver Education in Lewy Body Dementia | Jori Fleisher, Rush University Medical Center | A caregiver education and peer mentor program comprised of discussion and coaching through specific Lewy Body Dementia knowledge and social support topics | Lewy Body Dementia family caregivers | 2028 |
| Reducing Burden in Care Partners of Community-Dwelling Persons with Dementia and Oropharyngeal Dysphagia | Reducing Burden in Care Partners of Community-Dwelling Persons with Dementia and Oropharyngeal Dysphagia | Liron Sinvani, Feinstein Institutes for Medical Research | A comprehensive repository for Oropharyngeal Dysphagia related information for care partners of persons with Alzheimer’s disease and AD-related dementias and Oropharyngeal Dysphagia | Care partners of hospitalized patients with Alzheimer’s disease and related dementias and Oropharyngeal Dysphagia (Ages 65+) | 2025 |
| Roybal Center for Dementia Family Caregiver Mastery | Caregiver Bootcamp: Mastering the First Hundred Days | Carolyn Clevenger, Emory University | Online psychoeducation program to improve caregiver confidence and mastery | Caregivers of community-dwelling persons living with Alzheimer's disease or related dementias (Ages 18+) | 2029 |
| Improving health equities for Hispanic/Latino families living with dementia by validating a Spanish-language Caregiver-Enabled Care Program (CECP) in PACE participants | Improving Health Equities for Hispanic/Latino Families Living with Dementia by Validating a Spanish-language Caregiver-Enabled Care Program (CECP) in PACE Participants | Dirk Soenksen, Ceresti Health, Inc. | A Spanish-language Caregiver Enabled Care intervention that provides personalized education, proactive coaching, and remote monitoring, to address health disparities in dementia care for the Hispanic/Latino population in the U.S | Patients with dementia and their Spanish-speaking caregivers (Ages 18+) | 2025 |
| CARES: A Caregiver-Facing Digital Symptom Assessment Tool for Marginalized Older Adults with Serious Illness | CARES: A Caregiver-Facing Digital Symptom Assessment Tool for Marginalized Older Adults with Serious Illness | Sarah Nouri, University of California San Francisco (UCSF) | Digital symptom assessment tool for caregivers of homebound older adults with serious illness to assess and track symptoms and provide best practices for delivering care | Homebound older adults with serious illness (Ages 65+) and their caregivers and primary care team members (Ages 18+) | 2029 |
| Caregivers Preparing for Their Own Health Care Emergency | Caregivers Preparing for Their Own Health Care Emergency | Rebecca Boxer, University of California (UC) Davis | Online Emergency Preparedness Toolkit which gives caregivers step by step guide to document their specific caregiving activities | Adult spousal caregivers of persons living with dementia (Ages 18+) | 2026 |
| Cultural adaptation of a mobile caregiver intervention for Hispanic dementia caregivers | Cultural Adaptation of a Mobile Caregiver Intervention for Hispanic Dementia Caregivers | Miriam Rodriguez, Indiana University | A mobile telehealth application for informal caregivers to manage behavioral and psychological symptoms of dementia | Hispanic informal caregivers of patients living with Alzheimer's disease and related dementias | 2029 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Resilient Together for Dementia: A Live Video Resiliency Dyadic Intervention for Persons with Dementia and their Care-Partners Early after Diagnosis | Resilient Together for Dementia: A Live Video Resiliency Dyadic Intervention for Persons with Dementia and Their Care-partners Early After Diagnosis | Sarah Bannon, Icahn School of Medicine at Mount Sinai | Resilient Together for Dementia (RT-D), a live video dyadic resiliency intervention | Persons Living With Dementia, and Spousal Partner (SP) dyads, along with staff employed at MGH Department of Neurology | 2027 |
| Development and Pilot Testing of a Behavioral Economics Mobile Health Digital Tool to Improve Adherence to Non-Pharmacologic Strategies for Behavioral and Psychological Symptoms of Dementia | Development and Pilot Testing of a Behavioral Economics Mobile Health Digital Tool to Improve Adherence to Non-pharmacologic Strategies for Behavioral and Psychological Symptoms of Dementia | Hayley Belli, New York University School of Medicine | Behavioral economics mobile health (BE-mHealth) digital tool that will incorporate BE nudges into 2-3 evidence-based non-pharmacologic strategies for managing behavioral and psychological symptoms of dementia (BPSD) | Persons living with dementia and their primary care partners | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| The Caregiver Outcomes of Alzheimer's Disease Screening (COADS) Trial | Caregiver Outcomes of Alzheimer's Disease Screening (COADS) | Nicole Fowler, Indiana University-Purdue University Indianapolis | An early screening intervention involving sending letters to dyads and the primary care physician informing them of the results of the screening of Alzheimer's disease for earlier diagnosis | Dyads of older adults (Ages 65+) and family members (Ages 21+) | 2025 |
| To Reduce the Burden of Caregiving on Health Outcomes of Midlife Women: Asian American Family Caregivers of Persons Living with Alzheimer's Disease | Technology-based Information and Coaching Program Tailored for Asian American Midlife Women Who Are Family Caregivers of Persons With Alzheimer's Disease (TACAD) | Eun-Ok Im, University of Texas at Austin | The intervention is BC-Care (BrainCheck), a cognitive care planning tool that integrates patient, provider, and caregiver input to generate personalized Alzheimer's disease and related dementias (AD/ADRD) recommendations and follow-up care to be implemented during an AD/ADRD's patient's medical visit | Asian American women who are family caregivers of persons living with Alzheimer’s disease, and experts in gerontology/geriatrics | 2025 |
| Midwest Roybal Center for Health Promotion and Translation (Pilot) | Optimizing Cognition Via Exercise and Nutrition (OCEAN) | Susan Aguinaga, University of Illinois | A Latin dance program (BAILAMOS™) and Mediterranean diet (MIND) to improve cognitive function | Older Latino adults (Ages 50+) | 2029 |
| Rochester Roybal Center for Social Ties and Aging Research (Pilot) | Social-Life Enhancing Activities for Caregivers | Benzi Kluger, University of Rochester | Social LEAF (Life Enhancing Activities for Family Caregivers), a group video-conference intervention to teach caregivers coping skills to improve social relationships and social connection | Caregivers of community-dwelling family member with dementia with Lewy Bodies (DLB) | 2025 |
| Rochester Roybal Center for Social Ties and Aging Research (Pilot) | Study of a Behavioral Intervention for Older Advanced Cancer Patients and Their Caregivers | Lee Kehoe, University of Rochester | Life Review therapy, a behavioral intervention to address social connection in caregivers by focusing on the caregiving relationship | Caregivers and care receiver with mild cognitive impairment and advanced cancer (Ages 50+) | 2025 |
| Caregiver Speaks: A Technologically Mediated Storytelling Intervention for Family Caregivers of Individuals with Alzheimer's Disease and Other Dementias | Caregiver Speaks: A Technologically Mediated Storytelling Intervention | Debra Parker Oliver, Washington University in St. Louis | Caregiver Speaks, a technologically-mediated storytelling intervention using photos to illustrate various feelings and meanings | Adult hospice family caregivers of person's living with dementia (Ages 18 - 120) | 2025 |
| Using X to Enhance the Social Support of Hispanic and Black Dementia Caregivers (Tweet-SS) | X Based Social Support for Hispanic and Black Dementia Caregivers (Tweet-S2) | Sunmoo Yoon, Columbia University Health Sciences | X-based intervention to enhance the social support (informational, instrumental, emotional, appraisal) for Hispanic and Black dementia caregivers | Black or Hispanic dementia caregivers (Ages 18+) | 2025 |
| Advancing Alzheimer’s Family Caregiving Interventions and Research Capacity in Vietnam | A Multidomain Intervention Program for Older People With Dementia | Walter Hinton, University of California Davis | Multidomain intervention program that includes physical and cognitive exercises led by physiotherapists and management of metabolic and vascular risk factors by a cardiologist to address cognitive decline, quality of life, and functional ability | Individuals living in the community who have a diagnosis of mild-moderate vascular dementia (Ages 60+) | 2025 |
| Advancing Alzheimer’s Family Caregiving Interventions and Research Capacity in Vietnam | Efficacy of Paper-based Cognitive Training in Vietnamese Patients With Early Alzheimer's Disease | Walter Hinton, University of California Davis | Paper-based cognitive training | Vietnamese patients with early Alzheimer's disease and their caregivers | 2025 |
| Fostering Caregiver Connections via Intentional Technology Pairing for Caregivers of Patients with Alzheimer's Disease and Other Types of Dementia | A Study of Caregiver Connections Via Technology in Dementia | Matthew Knutson, Minnesota HealthSolutions Corporation | Algorithm to connect caregivers of people with dementia to each other for emotional support | Caregivers of persons living with dementia, such as Alzheimer’s disease, Lewy Body dementia and Frontotemporal degeneration | 2025 |
| Culturally Responsive Support Programming for Black Caregivers of Persons with Dementia | Culturally Responsive Caregiver Support | Sheria Robinson-Lane, University of Michigan | Culturally tailored support intervention for African American caregivers of persons living with dementia to reduce health disparities | African American caregivers of a person living with dementia (Ages 55+) | 2025 |
| Mobile App Delivered Mentalizing Imagery Therapy to Augment Remote Family Dementia Caregiver Skills Training | Mobile App Psychological Interventions for Family Dementia Caregivers | Felipe Jain, Massachusetts General Hospital | Guided imagery and mindfulness therapy delivered via mobile app to augment dementia caregiver skills training | Primary caregivers (ages 60+) for a relative with Alzheimer's disease and related dementias (AD/ADRD) that uses a smartphone at least 5 days/week | 2025 |
| A Home-based, Culturally and Language Specific Intervention for Dementia Family Caregivers: Stress Reduction and Education with Wearable Technology for Health | Dementia Family Caregiver Study | Jung-Ah Lee, University of California Irvine | Stress reduction and dementia education intervention with wearable technology to measure behavioral and physiological measures | Adult family caregivers of persons living with dementia | 2025 |
| Web-based CBT for Insomnia in Rural Dementia Caregivers: Examination of Sleep, Arousal, Mood, Cognitive, and Immune Outcomes | NiteCAPP: Web-based Interventions for Insomnia in Rural Dementia Caregivers (NiteCAPP) | Christina Mccrae, University of South Florida | NiteCAPP, a web cognitive behavioral treatment for insomnia (CBT-I) for rural dementia caregivers to improve caregiver health, mood, burden and cognition | Rural dementia caregivers and persons living with dementia | 2026 |
| Supporting Family Caregivers of Persons with Dementia | Supporting Family Caregivers of Persons With Dementia (ENCODE) | George Demiris, University of Pennsylvania | ENCODE (Empowering Caregivers of Patients with Dementia) is a behavioral intervention to support family caregivers in pain management for their hospice patients based on the transcriptional theory of stress and coping | Caregivers of hospice patients with Alzheimer's disease and related dementias (AD/ADRD) | 2026 |
| Addressing the Double Jeopardy of Stress and Hypertension Among African American Female Caregivers of Persons Living with Alzheimer's Disease and Related Dementias | Stress and Hypertension in Dementia Caregivers (MIM-DASH) | Kathy Wright, Ohio State University | Mindfulness in Motion (MIM) plus the Dietary Approaches to Stop Hypertension (DASH) interventions to improve caregiver stress and quality of life | African American female caregivers with hypertension (Ages 40+) | 2025 |
| Biobehavioral Mechanisms of Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons with Alzheimer's Disease | Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons with Alzheimer's Disease | Bryan Denny, Rice University | A smartphone-based cognitive emotion regulation training to improve caregiver health and well-being | Caregivers of individuals with Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| Caring4Caregivers: A Theory-driven Mobile Solution to Promote Self-care and Well-being Among Caregivers of Individuals with Alzheimer’s and Related Dementias | Compass for Care: A Theory-driven Mobile Solution to Promote Well-being Among Caregivers of Individuals With ADRD (Compass4Care) | Kerry Evers, Pro-Change Behavior Systems, Inc. | Caring4Caregivers (C4C), a theory-driven mobile solution to promote self-care and well-being among caregivers | Caregivers for individuals living with Alzheimer's disease and related dementia (AD/ADRD) | 2025 |
| Increasing Meaning to Reduce Loneliness in Care Partners of Persons with AD/ADRD | Reduce Loneliness in Care Partners of Persons With AD/ADRD | Allison Marziliano, Feinstein Institutes for Medical Research | RELOAD-C, an intervention leveraging concepts from Meaning-Centered Psychotherapy to reduce loneliness | Individuals with Alzheimer's disease and related dementias (AD/ADRD) and their care partners | 2027 |
| Midwest Roybal Center for Health Promotion and Translation (Pilot) | Promoting Physical Activity at a Memory & Aging Clinic | Naoko Muramatsu, University of Illinois Chicago | Pro-Home MeC, a 12-week in-home physical activity (PA) program, delivered using an app on a tablet hat has built-in motivational enhancement (e.g., music), that consists of: motivational enhancement components, including initial PA discussion between the patient and the memory care clinician, and goal setting with the interventionist; 5 moves for aerobics, strength, flexibility, and balance exercises that target daily functions | Adults diagnosed with mild cognitive impairment or mild dementia (Ages 50+) | 2029 |
| Rochester Roybal Center for Social Ties and Aging Research (Pilot) | The M&M Study | Kathi Heffner, University of Rochester | Social Engage Coaching (S-ENG), a behavioral intervention that involves one-on-one coaching with a care manager to increase social engagement and reduce loneliness | Caregivers for individuals living with Alzheimer's disease and related dementia (AD/ADRD) | 2025 |
| Writing to Heal: Developing an Internet-Based Cognitive-Behavioral Writing Intervention for Alzheimer’s Disease Spousal Caregivers | Writing to Heal: A Writing Intervention for ADRD Spousal Caregivers | Angie Leroy, Baylor University | An internet-based cognitive-behavioral writing intervention to improve caregiver health and well-being | Spousal caregivers for individuals living with Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| Developing a Culturally Immersive Psychoeducational Intervention for Black Immigrant Older Adults with Dementia and Their Caregivers: The Black Immigrant Project | Developing a Culturally Immersive Psychoeducational Intervention for Black Immigrant Older Adults with Dementia and Their Caregivers: The Black Immigrant Project | Manka Nkimbeng, University of Minnesota Twin Cities | The proposed intervention is The Active Caregiving Empowering Skills (ACES) intervention which is a psychoeducational program that is based on Cognitive Behavioral Therapy (CBT) to decrease caregiver stress and decrease behavioral distress in persons living with dementia | Black older adult immigrants (ages 50+) living with dementia and their informal caregivers | 2027 |
| I-CARE 2 RCT: Mobile Telehealth to Reduce Alzheimer's-Related Symptoms for Caregivers and Patients | I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms (I-CARE 2) | Richard Holden, Indiana University | Brain CareNotes app, a mobile telehealth app used by informal caregivers for behavioral and psychological symptoms of dementia (BPSD) management | Informal caregivers of people living with Alzheimer's disease and related dementias (AD/ADRD), and the care-recipients | 2027 |
| Using Mobile Technology to Reduce Stress in Caregivers of Persons with Dementia. A Scalable Solution to A Growing Problem | STRIDE: Stress Reduction in Dementia Caregivers | Ana-Maria Vranceanu, Massachusetts General Hospital | "CALM ", a smartphone-based meditation app that teaches users the basics of mindfulness and how to integrate it into daily life to promote sustained practice and provides 10- to 12-minute guided meditations with embedded behavioral principles [e.g., reminders] to facilitate adherence | Older adults with chronic pain comorbid with early cognitive decline (Ages 60+) | 2025 |
| The Mindful and Self-Compassionate Care Program (MASC): Reducing Stress for Caregivers of Persons with Dementia - Aim 3 | Supporting Our Caregivers in ADRD Learning (SOCIAL) | Christine Ritchie, Massachusetts General Hospital | MASC combines evidence-based skills from mindfulness programs, self-compassion programs, and behavioral management programs.An open pilot trial was delivered to 10 informal caregivers of ADRD individuals | Caregivers of persons living with dementia | 2025 |
| Reducing Suicide Risk Among Aging Caregivers of Persons with AD/ADRD: Adapting, Implementing, and Evaluating Dialectical Behavior Therapy Skills Training Interventions | Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD | Jonathan Singer, Texas Tech University | Dialectical behavior therapy skills training groups tailored to the unique experiences and needs of informal caregivers of persons with Alzheimer's Disease and related dementias to reduce suicide-related outcomes | Informal caregivers (Ages 50+) of persons with Alzheimer's disease and related dementias | 2026 |
| Supporting Dementia Caregivers During Medicare Home Health: Developing the DECLARE Needs Assessment Intervention | Supporting Dementia Caregivers During Medicare Home Health: Developing the DECLARE Needs Assessment Intervention | Julia Burgdorf, Visiting Nurse Service of New York | DECLARE, a self-assessment/web-based survey platform that asks caregivers about their needs and concerns, to improve home health care team communication with and in support of caregivers | Home health staff and Alzheimer’s disease and related dementias (AD/ADRD) caregivers | 2028 |
| The Living Memory Home: Reducing Grief and Improving Relationships Between Home-based Patients with ADRD and Their Family Caregivers | Living Memory Home-4-Dementia Care Pairs (LMH-4-DCP) | Holly Prigerson, Joan and Sanford I Weill Medical College of Cornell University | LMH-4-Dementia Care Pairs (LMH-4-DCP), a reminiscence-based intervention for family caregiver and person with dementia to address family caregivers' pre-loss grief and enhance relationship quality | Caregivers and persons with dementia | 2025 |
| Caregiving While Black-LIVE: Empowering Black Dementia Caregivers to Navigate Care | Caregiving While Black: LIVE | Fayron Epps, Emory University | Asynchronous/ synchronous psychoeducation intervention that promotes caregiving self-efficacy in Black caregivers | Adult family caregivers (Ages 40-75) to persons with Alzheimer’s disease and related dementia | 2025 |
| Plans4Care: Personalized Dementia Care On-Demand | Plans4Care: Personalized Dementia Care On-Demand | Sokha Koeuth, Plans4care Inc. | Software system that provides caregivers of persons with Alzheimer's disease or Alzheimer's disease related dementia with personalized, evidence-based strategies on-demand to address self-identified care challenges | Caregivers of persons living with Alzheimer's disease or Alzheimer's disease related dementia from a care setting | 2027 |
| Recharge Behavioral Therapy for Caregivers of Individuals with Alzheimer's Disease | Recharge Behavioral Therapy for Caregivers of Individuals with Alzheimer's Disease | Bruno Kajiyama, Photozig, Inc. | Recharge behavioral therapy delivered through the recharge mobile app to help reduce depressive symptoms and alleviate stress of caregivers of individuals with Alzheimer’s disease | Adult family caregivers (Ages 18+) to individuals with Alzheimer’s disease | 2026 |
| Enhancing American Indian Caregiver Mastery through a Savvy Caregiver Peer Program | Enhancing American Indian Caregiver Mastery through a Savvy Caregiver Peer Program | Jordan Lewis, University of Minnesota Twin Cities | Psychoeducational program informed by stress mediation and social cognitive theories aimed at alleviating caregiving strains and to strengthen knowledge, skills, and outlook of caregiving | American Indian family caregivers (Ages 18+) of persons living with Alzheimer’s disease and related dementias | 2028 |
| Development of a Physical Activity Intervention to Meet the Unique Needs of Sexual and Gender Minority (SGM) Alzheimer's Disease and Related Dementias (AD/ADRD) Caregivers | Development of a Physical Activity Intervention to Meet the Unique Needs of Sexual and Gender Minority (SGM) Alzheimer's Disease and Related Dementias (AD/ADRD) Caregivers | Andrew Pickett, Indiana University | A culturally relevant physical activity intervention to meet the unique physical activity needs of sexual and gender minority caregivers of people living with Alzheimer’s disease and related dementias | Sexual and gender minority caregivers of people living with Alzheimer’s disease and related dementias | 2028 |
| STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners | STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners | Allison Lindauer, Oregon Health & Science University | A multi-component behavioral intervention designed to teach care partners of adults with frontotemporal dementia to identify strategies for effective management of distressing behaviors exhibited by their family member | Persons living with frontotemporal dementia and their family care partners (Ages 18+) | 2029 |
| Testing the effects of a text message caregiver support intervention for Latinos | Testing the Effects of a Text Message Caregiver Support Intervention for Latinos | Jaime Perales, The University of Kansas Medical Center | A text message intervention that includes daily automatic messages tailored to Latino caregivers to improve caregiver support | Adult caregivers (Ages 18+) | 2029 |
| Northwell Roybal Center for Personalized Trials: Physical Activity Promotion for Persons Giving Care or Living with AD/ADRD | A Behavior Change Technique (BCT) Intervention to Develop an Hourly Activity Habit Among Caregivers for Persons with AD/ADRD | Mark Butler, The Feinstein Institutes for Medical Research | Behavior Change Therapy intervention to set goals, plan actions, self-monitor, and form habits for caregivers to reduce sedentary behavior by forming a habit of hourly physical activity per day | Caregivers of persons living with Alzheimer's or related dementias | 2029 |
| Northwell Roybal Center for Personalized Trials: Physical Activity Promotion for Persons Giving Care or Living with AD/ADRD | A Behavior Change Technique (BCT) Intervention to Develop a Walking Habit Among Caregivers for Persons with AD/ADRD | Mark Butler, The Feinstein Institutes for Medical Research | Behavior Change Therapy intervention to reduce the amount of time that caregivers spend sedentary by developing a habitual period of daily walking | Caregivers of persons living with Alzheimer's or related dementias | 2029 |
| Effect of Cognitive Empathy Training on Dementia Caregivers | Effect of Cognitive Empathy Training on Dementia Caregivers | James Rilling, Emory University | An intervention developed to reduce relational strain and improve relationship quality between caregivers and their care recipients living with dementia by fostering cognitive understanding of what someone else is thinking or feeling | Caregivers of persons living with dementia (Ages 21+) | 2029 |
| Improving screening and access to treatment for depression in care partners of people living with dementia | Improving Screening and Access to Treatment for Depression in Care Partners of People Living with Dementia | Lisa Mistler, Dartmouth-Hitchcock Clinic | The iPath*D intervention is an online system that presents information to individuals on their depression symptoms and treatment options that can be pursued either in-person or online to address existing barriers to care | Care partners of persons living with dementia | 2026 |
| Adaptation and feasibility testing of an AI-enabled web app based on acceptance and commitment therapy for family caregivers of people with dementia | Adaptation and Feasibility Testing of an AI-enabled Web App Based on Acceptance and Commitment Therapy for Family Caregivers of People with Dementia | Areum Han, The University of Alabama at Birmingham | An AI-enabled web app (WeACT) based on acceptance and commitment therapy to promote mental health in family caregivers of persons living with dementia | Family caregivers of persons living with dementia | 2026 |
| Competence, Autonomy, Relatedness, and Connections (CARe Connections): A Peer-Led Intervention Designed with Parkinsons Disease & Related Disorders Carepartners to Improve Holistic Support | Competence, Autonomy, Relatedness, and Connections (CARe Connections): A Peer-Led Intervention Designed with Parkinsons Disease & Related Disorders Carepartners to Improve Holistic Support | Sandhya Seshadri, University of Rochester | An online, peer-led psychoeducational intervention that targets the positive and negative dimensions of caregiving to enhance competence, autonomy, and build social connections | Care partners of persons living with Parkinson’s disease and related disorders | 2029 |
| Roybal Center for Dementia Family Caregiver Mastery (Pilot) | Cultural Adaptation of an Online Caregiver Mastery Program for Latino Dementia Caregivers | Ken Hepbur, Emory University | TBD | TBD | 2029 |
| CommunityRx-Dementia + Peer Navigation (CRxDpeer): A Real-World Implementation and Effectiveness Study of an IT-Based Social Care Intervention | CommunityRx-Dementia + Peer Navigation (CRxDpeer): A Real-World Implementation and Effectiveness Study of an IT-Based Social Care Intervention | Stacy Lindau,University of Chicago | The intervention, CommunityRx-Dementia + Peer (CRxDpeer) is an iteration of the CommunityRx-Dementia (CRxD) intervention adapted to includes a peer support component | Caregivers of persons living with dementia | 2030 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Communication-based Intervention for Early Stage Dementia Patient-Caregiver Dyads to Increase Engagement in Advance Care Planning and Reduce Caregiver Burden | Developing a Communication Intervention for People with Memory Changes and Their Caregivers | Sara Czaja, Joan and Sanford I Weill Medical College of Cornell University | Communication-based intervention to improve preparedness for advance care planning (ACP) | Adults with Alzheimer's disease and related dementias and their caregivers | 2025 |
| Safety in Dementia: An Online Caregiver Intervention | "Safety in Dementia": An Online Caregiver Intervention | Marian Betz, University of Colorado Anschutz Medical Campus | RCT of the “Safety in Dementia” (SiD) online tool to address firearm access, thereby reducing injury risk, among informal caregivers of community-dwelling adults with dementia | Informal caregivers of community-dwelling adults with dementia | 2025 |
| Integration of Health Information Technology and Promotion of Personhood in Family-Centered Dementia Care | Integration of Health Information Technology and Promotion of Personhood in Family-Centered Dementia Care | Ellen Brown, Florida International University | Assistive alternative communication device for persons living with dementia to communicate care preferences to caregiver and provider | Dyads of caregivers and persons living with dementia | 2025 |
| Designing a Culturally Tailored Formal Care Decision-Making Intervention for African American Dementia Dyads and Families | DECIDE: Dyads and Families | Kalisha Johnson, Emory University | Tailored strategies to support formal care decision-making processes | African-American parent-adult daughter dyad | 2026 |
| Adapting Supported Decision Making to Promote Well-being and Improve Health Outcomes for Persons Living with Alzheimer's Disease and Alzheimer's Disease Related Dementias | Supported Decision Making for AD/ADRD | Emily Largent, University of Pennsylvania | A toolkit to improve decision-making | Individuals living with Alzheimer's disease and related dementia (AD/ADRD), their care partners, and providers | 2027 |
| Enhancing Triadic Communication About Cognition for Older Adults with Alzheimer's Disease or Related Dementias Facing a Cancer Management Decision | Enhancing Triadic Communication about Cognition for Older Adults with Alzheimer's Disease or Related Dementias Facing a Cancer Management Decision (COACH-Cog) | Allison Magnuson, University of Rochester | COACH-Cog, an adapted tool to facilitate conversations about aging-related conditions, such as cognition, with older patients and their care partners | Dyads of people living with dementia and their care partners | 2027 |
| The Role of Visit Audio Recordings in Triadic Dementia Care | The Role of Visit Audio Recordings in Triadic Dementia Care | Paul Barr, Dartmouth College | HealthPAL, a visiting recording platform to improve tridiatic interpersonal communications | IIndividuals with Alzheimer's disease and related dementia (AD/ADRD), care partners, and providers | 2027 |
| Adapting and Testing the Care Partner Hospital Assessment Tool (CHAT) for Use in Dementia Care | Dementia Care Partner Hospital Assessment Tool | Beth Fields, University of Wisconsin - Madison | Care Partner Hospital Assessment Tool (CHAT): a novel approach designed to increase care partner preparedness for caregiving tasks during their family member or friends’ hospitalization | Patients living with Alzheimer's disease and related dementia (AD/ADRD) and their care partners, healthcare system administrators, and clinicians | 2027 |
| Negotiation Training to Optimize Caregiver Communication in Alzheimer's Disease | Negotiation Training for Caregiver Communication in AD | Lee Lindquist, Northwestern University | Negotiation and dispute resolution training program for caregivers of persons living with dementia | Adult family caregivers of persons living with dementia that provide at least 10 hours weekly support | 2025 |
| Shared Decision-Making for Firearm Safety among Older Adults with Early Changes Associated with Alzheimer’s Disease/Alzheimer’s Disease-Related Dementias (AD/ADRD) | Decision Making Tool for Firearm Storage | Elizabeth Phelan, University of Washington | A video decision aid intervention to improve firearm safe storage among older adults | Older adults with mild cognitive impairment or early dementia and/or depression (Ages 65+) | 2025 |
| MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimers Disease and Related Dementias (CONFIDE-ADRD): Let's Talk Tech (pilot) | MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer's Disease and Related Dementias (CONFIDE-ADRD) | Clara Berridge, Massachusetts General Hospital | A self-administered dyadic education and communication tool developed to help dementia caregivers make person-centered decisions about technology choices to support caregiving | Persons living with mild cognitive impairment or mild stage Alzheimer’s disease and related dementias (Ages 55+) and their caregiver (Ages 18+) | 2026 |
| MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimers Disease and Related Dementias (CONFIDE-ADRD): Adapting the SHARE for Dementia Early Stage Dyadic Intervention: A Stage 1 Pilot Study with African American Families | Adapting the SHARE for Dementia Early Stage Dyadic Intervention: A Stage 1 Pilot Study with African American Families | Silvia Orsulic-Jeras, Massachusetts General Hospital | Silvia Orsulic-Jeras, Massachusetts General Hospital | Non-Latinx African American individuals with mild to moderate dementia (Ages 50+) and their caregivers (Ages 18+) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Nursing Home Pragmatic Clinical Trial of APPROACHES (Aligning Patient Preferences: A Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support) | Aligning Patient Preferences: a Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support (APPROACHES | Susan Hickman, Indiana University-Purdue University Indianapolis | APPROACHES, an Advance Care Planning (ACP) Specialist Program to improve care and reduce unwanted, burdensome hospitalizations through improved ACP procedures, standardized staff education on ACP, and systematic ACP facilitation delivered by nursing home staff | Adults with Alzheimer's disease and related dementias, their family caregivers, and nursing home providers | 2025 |
| Using the Electronic Health Record to Identify and Promote Goals-of-Care Communication for Older Patients with Serious Illness | Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2) (PICSI-H) | Ruth Engelberg, University of Washington | Electronic health record (EHR)-based Clinician Jumpstart intervention to promote goals-of-care communication for older patients with serious illness | Older adults (Ages 65+; adults ages 65 - 79 must have 1+ chronic condition) | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Cognitive Stimulation Therapy for Dementia: A Two-Armed Pragmatic Tria l | Michael Lepore, University of Maryland School of Nursing | Cognitive Stimulation Therapy (CST), an online group intervention to actively engage and stimulate cognitive processes of persons living with dementia to reduce depressive symptoms | Persons living with dementia | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Collaborative Care Coordination Program for Alzheimer's Disease and Related Dementias (Co-CARE-AD) | Xiaojuan Li, Harvard Pilgrim Health Care, Inc. | Dementia Care Consultation (DCC) program, a collaborative care coordination program delivered by a care consultant to reduce patient healthcare utilization and improve caregiver knowledge and well-being | Dyads of persons living with dementia and their caregiver | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Deprescribing of Diabetes Regimens in Long Term Care Residents With Alzheimer's | Medha Munshi, Harvard Medical School | An educational intervention directed at Long Term Care Facility (LTCF) staff to deprescribe and reduce the number of high risk medications (HRMs) in long term care facility (LTCF) residents with diabetes and ADRD | Long-term care facility (LTCF) providers and LTCF residents with diabetes and Alzheimer's disease and related dementias (AD/ADRD) | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems | Richard Fortinsky, University of Connecticut Health Center | Tele-Savvy, an online program to improve caregiver mastery | Family members/informal caregivers of people living with dementia | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Virtual Training for Latino Caregivers to Manage Symptoms of Dementia | Magaly Ramirez, University of Washington | STAR-VTF is a program that teaches caregivers skills to reduce behavioral and psychological symptoms of dementia | Caregivers of persons living with dementia | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Implementation of MIND at Home Into Primary Care for People Living With Dementia | Elizabeth Ciemins, American Medical Group Association | MIND at Home is a dementia care coordination model that includes coordination between persons living with dementia, their care partner, a memory care coordinator and their provider | Dyads of caregivers and individuals with dementia | 2025 |
| Improving Post-Diagnosis Dementia Care in Primary Care | Improving Post-Diagnosis Dementia Care in Primary Care | Halima Amjad, Johns Hopkins Bayview Medical Center | Pragmatic intervention to facilitate high quality, comprehensive post-diagnosis care and improve quality of care and patient outcomes | Persons living with dementia, in traditional primary care settings | 2025 |
| I mpact of a Novel Socially Assistive Robotic Architecture on Engaging Older Adults with Mild Cognitive Impairment, Alzheimer's Disease, and Related Dementia in Long Term Care Settings | Use of Socially Assistive Robots for Long Term Care Older Adults With Cognitive Impairment and Apathy | Nilanjan Sarkar, Vanderbilt University | Socially assistive robot to interact with long-term care setting residents with either dementia or mild cognitive impairment | Person living with dementia or mild cognitive impairment in assisted living or nursing home facilities (Ages 70+) | 2025 |
| Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) | Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) | Miguel Vazquez, University of Texas, Southwestern Medical Center | Pragmatic trial of intensive blood pressure management | Older adults (Ages 70+) | 2025 |
| Screening for Cognitive Impairment Following Critical Illness: Designing and Testing an Implementation Program to Support High Risk Older Adults | Anticipating Decline and Providing Therapy (ADAPT) | Jessica Palakshappa, Wake Forest University | Cognitive screening program for incident mild cognitive impairment or Alzheimer's disease and related dementias | Older adults with critical illness | 2026 |
| Enhancing Shared Decision-making to Prompt and Guide Individualized Care for People with Alzheimer's Disease and Diabetes | Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes | April Savoy, Purdue University | Shared Decision-Making Tool: new internet based interactive information visualizations designed to facilitate shared decision-making and recognize certain needs; Continuous Glucose Monitoring: a wearable device that continuously monitors glucose levels in near real-time | Individuals with Dementia and Diabetes and their caregivers | 2027 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | A Patient-facing Tool To Reduce Opioid-Psychotropic Polypharmacy in People Living With Dementia (PLWD) | Donovan Maust, University of Michigan | The intervention, EMPOWER, is an educational brochure focused on the risks associated with psychotropic and opioid polypharmacy that will be sent to participant via mail to "nudge”/encourage them to have discussions with the prescribing clinicians about the inappropriateness of the regimen to lower polypharmacy exposure for persons living with dementia | Persons living with dementia | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Perspectives on Embedded Patient Priorities Care (PEP Talks) | Jennifer Carnahan, Indiana University Health | Patient Priorities Care (PPC), is an evidence-based program to identify the goals and values of patients and care partners by 1) the clinician contacting the patient and care partner for a discussion of their priorities and 2) integration of priorities into the patient’s care plan | Patients with mild cognitive impairment or dementia | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Integration of Machine Learning and Clinical Decision Support to Prevent Postoperative Delirium in Patients with Cognitive Impairment (Demo) | Ira Hofer, Icahn School of Medicine at Mount Sinai | CDS prompts, a series of prompts following the notification that a patient is at increased risk of postoperative delirium (POD) to promote best clinical practices for the prevention of POD | Attending physicians and their adult patients with a history of cognitive impairment who will be undergoing surgery | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Reducing Inappropriate Medication Use for BPSD | Helen Kales, University of California Davis | Describe, Investigate, Create, Evaluate (DICE) is an intervention to manage behavioral and psychological symptoms of dementia (BPSD). DICE includes a 6-hour online modular training, manual, and additional training as needed coaching from a DICE trainer that will be completed by clinic social workers (called Onsite DICE Coordinators or ODCs). | Persons living with dementia and their care partner dyads | 2025 |
| The Care Ecosystem Response to COVID-19: Accelerating Research on Dementia Care that Meets the Needs of Caregivers and Persons with Dementia during COVID-19 | The Care Ecosystem Consortium Effectiveness Study | Katherine Possin, University of California San Francisco | The Care Ecosystem, a team-based care model that can lead to quality improvements for family caregivers and formal care providers | Family caregivers and formal care providers | 2025 |
| Developing and Testing a Population Health Approach to Deprescribing and Optimizing Medications in Older Adults | Population Health Approach to Optimizing Medications in Older Adults (POP-MED) | Michelle Keller, University of Southern California | Pharmacist-led deprescribing intervention aimed at reducing inappropriate medications | Patients with 5 medications prescribed and a face-to-face primary care encounter in the last year (Ages 65+) | 2027 |
| Developing, Implementing, and Evaluating a Caregiver and Elder Abuse Screening, Risk Assessment and Treatment to Improve Outcomes for Older and Vulnerable Adults with MCI/ADRD | Caregiver and Elder Abuse Screening, Risk Assessment and Treatment to Improve Outcomes for Older and Vulnerable Adults with MCI/ADRD | Monique Pappadis, University of Texas Medical Branch | Caregiver and Patient Abuse assessment For Older and Vulnerable populations (CAPA-OV), a screening and intervention tool for use in primary care settings to screen for elder abuse among older and vulnerable adults with mild cognitive impairment or Alzheimer's disease and related dementias (AD/ADRD), as well as the inclusion of a risk assessment for accompanying caregivers | Persons living with dementia (Ages 65+), their caregivers, and healthcare providers | 2025 |
| The Effect of Smart Ambient Bright Light for Nursing Home Residents with Alzheimer's Disease and Related Dementias | Smart Lighting for Nursing Home Residents With Dementia | Ying-Ling Jao, Pennsylvania State University | The intervention is a smart ambient bright light (SABL) intervention which includes tunable LED lights, photosensors, and controllers | Nursing home residents with Alzheimer's disease and related dementia (AD/ADRD) (Ages 55+) | 2025 |
| Making Connections Thru Music: A Group Music Therapy-Based Intervention for Persons with Dementia | Making Connections Thru Music: A Group Music Therapy-Based Intervention for Persons with Dementia | Gregg Gorzelle, Hopeful Aging LLC | Making Connections Thru Music (MCTM) sessions, an evidence-based music and discussion intervention to improve engagement, enhance quality of life, and reduce behavioral expressions in persons with dementia | Caregiving volunteers and resident living staff for persons living with dementia | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Testing the Feasibility of the Individualized Positive Psychosocial Intervention (IPPI) | Katherine Abbott, Brown University | A Individualized Positive Psychosocial Intervention (IPPI) program that tailors activities to resident preferences and provides people living with dementia with preference-based, person-centered care to improve their mood and reduce communication of distress. | Persons Living With Dementia residing in nursing homes | 2025 |
| VoiceLove: An App-Based COMmunication Tool Designed to Address DeliriUm and Improve Family ENgagement and PatIent/Family SatisfaCtion in CriticAlly Ill PaTiEnts (COMMUNICATE) | VoiceLove: An App-based Communication Tool Designed to Address Delirium and Improve Family Engagement and Patient/Family Satisfaction in Critically Ill Patients (COMMUNICATE) | E. Wesley Ely, Voicelove LLC | VoiceLove is a HIPAA-compliant mobile application that enables expanded family engagement for patients in the Intensive Care Unit (ICU) | Clinicians, patients, and family members within medical, surgical, and coronary Intensive Care Units (ICU) | 2025 |
| Natives Engaged in Alzheimer's Research | Cognition After OSA Treatment Among Native American People (CATNAP) | Denise Dillard, Washington State University | Positive airway pressure therapy, a behavioral intervention for obstructive sleep apnea, to improve sleep quality, cognitive function, and vascular risk factors for Alzheimer's disease and related dementias | American Indians from Strong Heart Study communities (Ages 55+) | 2026 |
| A Pragmatic Crossover Trial to Test the Effectiveness of a Novel Lighting System to Reduce Nighttime Falls in Persons with Alzheimer’s Disease and Related Dementias | The Nightlight Falls Prevention Study | Sheryl Zimmerman, University of North Carolina at Chapel Hill | A lighting intervention to reduce nighttime falls | Individuals with Alzheimer's disease and related dementia | 2027 |
| Enhancing Sleep Quality for Nursing Home Residents with Dementia: Pragmatic Trial | Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase ( 40Winks ) | A. Lynn Snow, University of Alabama | Improve clinical outcomes for nursing home residents with Alzheimer's disease or related dementias by testing an evidence-based intervention to improve these residents' sleep | Individuals with Alzheimer's disease or related dementia (Ages 50+) | 2027 |
| U.S. Deprescribing Research Network | PPC Deprescribing | Micheal Steinman, University of Texas Health Science Center at Houston | Patient Priorities Care (PPC), a three-step care plan regarding the implementation of priorities identification and alignment of deprescribing practices as part of the routine care of adults living with dementia | Adults with dementia (ages 65+) and their caregivers | 2025 |
| ED-LEAD: Emergency Departments Leading the Transformation of Alzheimer's and Dementia Care | ED-LEAD: Emergency Departments Leading the Transformation of Alzheimer's and Dementia Care | Joshua Chodosh, New York University School of Medicine | Emergency and post-emergency care through patient-care partner focused interventions: 1) Emergency Care Redesign; 2) Nurse-led Telephonic Care; and 3) Community Paramedic-led Transitions Intervention | Persons living with dementia who visit the emergency department (Ages 66+) | 2028 |
| Testing the Pain-CPG-EIT | Testing the Pain Clinical Practice Guideline | Barbara Resnick, University of Maryland, Baltimore | The study will evaluate the efficacy and treatment fidelity of an intervention to improve assessment, diagnosis and management of pain (Pain Management Clinical Practice Guideline, PAIN-CPG-EIT) among nursing home residents living with dementia | Nursing home residents living with dementia (Ages 65+) | 2028 |
| Impact of Hourly Neurochecks in Critically Ill Older Adults | Short-term and Longer-term Cognitive Impact of Neurochecks | Jamie Labuzetta, University of California San Diego | Determining if the frequency of checking neurological health affects cognitive outcomes of Intensive Care Unit patients | Adult patients (ages 55+) after uncomplicated elective coiling of unruptured cerebral aneurysm | 2028 |
| Impact of Hourly Neurochecks in Critically Ill Older Adults | Impact of Hourly Neurochecks in Critically Ill Older Adults | Jamie Labuzetta, University of California San Diego | Determining if the frequency of checking neurological health affects cognitive outcomes of Intensive Care Unit patients after an acute brain injury | Older adult patients with spontaneous acute intracerebral hemorrhage with radiographic and clinical stability greater than 6 hours following admission to the Intensive Care Unit (Ages 55+) | 2028 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Pragmatic Use of PAIN-Advanced Dementia Scale in Emergency Departments | Teresita Hogan, University of Chicago | A Clinical Decision Support (CDS) to propel the PAIN-Advanced Dementia (PAINAD) scale into the routine emergency care | Medically stable emergency department patients with co-existent hip pain and history of dementia | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Primary Care-Based Pilot ePCT of an Online Workshop for Family Caregivers of PLWD | Veronica Yank, University of California San Francisco | Online, peer-led small group workshop intervention for family caregivers to increase self-management behaviors, dementia caregiving skills, and peer social support | Family caregivers (Ages 18+) of persons living with dementia | 2024 |
| Autonomous Navigating Robot for Detecting Falls and Risk of Falls in Nursing Home Residents with Alzheimer's Disease /ADRD | Autonomous Navigating Robot for Detecting Falls and Risk of Falls in Nursing Home Residents with Alzheimer's Disease/ADRD | Yuval Malinsky, Vigorous Mind Inc. | The Vigorous Mind Robot (VMR), an autonomous robot with an infra-red camera that will be employed in nursing home dementia units to alert staff and identify falls for early intervention | Subjects living on Dementia Memory Unit in three different nursing homes | 2025 |
| Adapting the CHATO Communication Intervention for Diverse Nursing Home Communities | Adapting the CHATO Communication Intervention for Diverse Nursing Home Communities | Kristine N Williams, The University of Kansas Medical Center | A culturally adapted online training intervention developed to train nursing home staff on improved communication skills with residents | Direct care staff and permanent employees of nursing homes | 2029 |
| Optimizing the Daily Care Interactions Between Direct Care Staff and Assisted Living Residents with Dementia | Optimizing the Daily Care Interactions Between Direct Care Staff and Assisted Living Residents with Dementia | Anju Paudel, Pennsylvania State University, The | The promoting positive care interactions intervention was developed to optimize daily care interactions between staff and residents | Residents with Alzheimer's Disease and Related dementias (Ages 65+) in assisted living and staff engaged in their care | 2026 |
| Primary Care Screening and Intervention for Elder Neglect in Patients with Dementia: An Evidence-Based Approach | Primary Care Screening and Intervention for Elder Neglect in Patients with Dementia | Anthony Rosen, Joan & Sanford I Weill Medical College of Cornell University | The interventions of this study include a novel primary care screening tool and a caregiver point-of-care technology-driven intervention to identify, intervene, and prevent neglect and improve the health of this vulnerable population | Dyads of older adults (ages 60+) and their caregiver | 2027 |
| Risk Screening & Primary Prevention of Elder Abuse in People Living with Dementia | Risk Screening & Primary Prevention of Elder Abuse in People Living with Dementia | Laura Mosqueda, University of Southern California (USC) | The Risk Assessment Screen (RAS), an Outcome Tool and a brief, multi-component intervention to facilitate effective caregiving strategies and alerts care partners/caregivers to risks of elder mistreatment | Self Identified primary care partner/caregiver role of persons living with dementia residing in Southern California | 2027 |
| Detection of Elder mistreatment Through Emergency Care Technicians - Revised for Primary Care (DETECT-RPC) | Detection of Elder mistreatment Through Emergency Care Technicians - Revised for Primary Care (DETECT-RPC) | Michael Cannell, The University of Texas Health Science Center at Houston | Detection of Elder mistreatment Through Emergency Care Technicians- Revised for Primary Care (DETECT-RPC), a brief screening tool that allows primary care clinicians to quickly and systematically surveil older adults and their physical and social environment without need for direct questioning of the older adult or their caregiver | Clinicians and caregiver dyads of older adults living with Alzheimer's disease and related dementias (Ages 60+) | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| MEMORI Corps: A Novel Activity-based Companion Care Program to Benefit Community-Living Persons with Dementia, their Families, and Senior Volunteers | MEMORI Corps: Activity-based Companion Care for Dementia (MEMORI Corps) | Quincy Samus, Johns Hopkins Bayview Medical Center | Activity-based home healthcare to treat people with dementia | People with dementia (Ages 55+) and caregivers (Ages 18+) | 2025 |
| Impact of Novel Rehabilitative Approaches for Dysphagia in Patients with Alzheimer's Disease and Related Dementias | Interventions for Patients With Alzheimer's Disease and Dysphagia | Nicole Rogus-Pulia, University of Wisconsin - Madison | Dysphagia rehabilitative interventions (lingual strengthening and saliva substitute use) to improve swallowing-related outcomes | Older adults with diagnosis of dementia, cognitive impairment, or memory loss (Ages 55 - 90) | 2025 |
| A Dyadic Approach for a Remote Physical Activity Intervention in Adults with Alzheimer’s Disease and their Caregivers | A Dyadic Approach for a Remote Physical Activity Intervention in Adults With AD and Their Caregivers | Lauren Ptomey, University of Kansas Medical Center | Moderate physical activity intervention for adults with Alzheimer’s Disease and their Caregivers to improve mobility | Adults with mild moderate Alzheimer's disease and their caregivers (Ages 55+) | 2025 |
| Developing a PRogram to Educate and Sensitize Caregivers to Reduce the Inappropriate Prescription Burden in Elderly with Alzheimer's Disease Study (D-PRESCRIBE-AD) | A Program to Reduce Inappropriate Medications Among Older Adults With Alzheimer's Disease (D-PRESCRIBE-AD) | Jerry Gurwitz, University of Massachusetts Medical School | Patient/caregiver-centered, multifaceted educational intervention on inappropriate prescribing | Older adults with Alzheimer's disease and related dementias (AD/ADRD) | 2025 |
| Using Design Thinking Approaches to Tailor a Dyadic Behavioral Sleep Intervention for Persons Living with Dementia and Their Caregivers | Sleep Enhancement for Older Adults Living With Memory Loss And Their Care Partners (SLEEPMATE) | Glenna Brewster Glasgow, Emory University | T-Dyadic Sleep, a cognitive behavioral therapy for insomnia (CBTI) intervention to examine acceptability and feasibility as well as preliminary efficacy on objective and subjective sleep outcomes | Persons living with mild cognitive impairment or early-stage dementia and their caregivers | 2026 |
| Music-based Intervention for Insomnia in Persons Living with Dementia and their Caregivers | Music-based Intervention for Insomnia in Persons Living with Dementia and their Caregivers | Darina Petrovsky, Duke University | Tailored music-based mobile application aimed at improving insomnia symptoms in persons living with dementia | Underrepresented community-dwelling persons living with dementia and their caregivers | 2026 |
| A Dyadic Approach to Improve Sleep and Well-being Among Persons with Alzheimer's Disease and Their Caregivers | A Dyadic Sleep Health Approach for Persons With Alzheimer's Disease and Caregivers | Yeonsu Song, University of California Los Angeles | Dyadic sleep intervention to improve subjective and objective sleep quality | Dyads of people living with dementia and their care partners | 2027 |
| Addressing Hearing Loss as a Common Unmet Contributor to Neuropsychiatric Symptoms | Addressing Hearing Loss as a Common Unmet Contributor to Neuropsychiatric Symptoms | Esther Oh, Johns Hopkins Bayview Medical Center | A hearing care intervention to treating neuropsychiatric symptoms | Individuals living with Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| Improving Person-Environment Fit of Community-Residing Older Adults with Dementia Through Assessment and Individualized Intervention | Person-Environment Fit for Persons With Dementia | Elizabeth Rhodus, University of Kentucky | Harmony at HOME will provide caregiver training for assessment of the environment as an antecedent to behaviors of the person with Alzheimer's disease and related dementias & implementation of environmental cueing as a tool to create a supportive environment for functional behaviors and activity participation | Persons living with dementia and their care partners | 2027 |
| Randomized Clinical Trial of a Brief, Anxiety Intervention for Mild Cognitive Impairment/mild Alzheimer’s Disease and their Care Providers | Treatment of Stress and Anxiety in MCI/Mild ADRD | Norman Schmidt, Florida State University | Cognitive anxiety sensitivity treatment (CAST): a brief, fully computerized CBT-based intervention in people living with mild cognitive impairment | Dyads consisting of persons with mild cognitive impairment or mild Alzheimer's disease and related dementias (AD/ADRD) and their care partners | 2027 |
| Home Alone: Developing a Home-Based Intervention for People with Cognitive Impairment Who Live Alone | Home Alone: An Intervention for People With Cognitive Impairment Who Live Alone | Joseph Gaugler, University of Minnesota Twin Cities | Home Alone combines behavioral activation (BA) with other evidence-based intervention approaches (i.e., Tailored Activity Program/TAP; Skills2Care®) that target the environment in order to tailor activity that is fulfilling and meaningful to persons with cognitive impairment | Persons with cognitive impairment who live alone | 2024 |
| eAlign: A Patient Portal-based Intervention to Align Medications with What Matters Most | A Patient Portal-based Intervention to Align Medications with What Matters Most (eAlign) | Ariel Green, Johns Hopkins Bayview Medical Center | eALIGN, a patient portal intervention to align medication decisions with persons living with Alzheimer's disease and related dementias (AD/ADRD) and care partners' goals, provide care partner training in the use of nonpharmacologic methods to address behavioral and psychological symptoms of dementia, and reduce polypharmacy and potentially inappropriate medication use | Older adults with diagnosis of Alzheimer's disease and related dementia who receive 5 or more chronic daily medications (Ages 65+) | 2027 |
| Promoting Independence with Compensatory Cognitive Rehabilitation: A Pilot Clinical Trial for Early-Stage Alzheimer's Disease | Promoting Independence With Compensatory Cognitive Rehabilitation | Alyssa Lanzi, University of Delaware | A behavioral treatment, Structured External Memory Aid Treatment (SEMAT), to promote independent living skills | Adults with mild cognitive impairment (Ages 65 - 85) | 2026 |
| U.S. Deprescribing Research Network | Adapting the Shed-MEDS Deprescribing Intervention to Dementia Care in Assisted Living | Jennifer Kim, Vanderbilt University | A patient/ surrogate-centered deprescribing intervention adapted for dementia (Shed-MEDS) to reduce exposure to unnecessary or potentially harmful medications among residents with dementia living in an assisted living facility | Residents of an assisted living facility with dementia who are taking 5+ medications or 1 potentially inappropriate medication | 2025 |
| A Stakeholder Derived Intervention to Enhance Technology Engagement and Reduce the Emotional Divide in Distance Caregiving of Older Adults with Cognitive Impairment | A Stakeholder Derived Intervention to Enhance Technology Engagement and Reduce the Emotional Divide in Distance Caregiving of Older Adults with Cognitive Impairment | Alyssa Weakley, University of California Davis | Interactive-Care (I-Care), remote caregiver platform to improve everyday functioning and independence of care receivers, remote caregiver involvement, and the emotional bond between the dyad | Mild Alzheimer's disease and related dementia / cognitively impaired care receiver and remote caregivers | 2028 |
| Developing a Nonpharmacological Pain Intervention for Community Dwelling Older Adults with Dementia | Developing a Nonpharmacological Pain Intervention for Community Dwelling Older Adults with Dementia | Annalisa Na, Drexel University | A program where participants will start each session with pain, vital signs, and environmental assessments; then receive an individualized home-based exercise program | People living with mild to very mild dementia with osteoarthritis (Ages 65+) and their caregiver | 2027 |
| A Social Engaging Restorative Virtual Environment (SERVE) Volunteer Intervention to Support Social Engagement and Well-being in Older Adults with Cognitive Impairment | A Social Engaging Restorative Virtual Environment (SERVE) Volunteer Intervention to Support Social Engagement and Well-Being in Older Adults with Cognitive Impairment | Saleh Kalantari, Cornell University | A VR-based intervention to improve the wellbeing and quality of life of older adults with mild cognitive impairment | Older adults with mild cognitive impairment and non-impaired older adult volunteers | 2028 |
| Implementing and Scaling the STEADI Fall Prevention Algorithm Using a Conversational Relational Agent for Community-Dwelling Older Adults With and Without Mild Cognitive Impairment | Implementing and Scaling the STEADI Fall Prevention Algorithm Using a Conversational Relational Agent for Community-Dwelling Older Adults With and Without Mild Cognitive Impairment | Chantal Kerssens, care.coach | A digital technology avatar-based fall prevention program to reduce the rate and risk of falling | Community dwelling mild cognitively impaired and cognitively normal participants (Ages 65+) | 2025 |
| An Efficacy Trial of Community Health Worker-Delivered Chronic Pain Self-Management Support for Vulnerable Older Adults | Chronic Pain Self-management for Older Adults With Cognitive Impairment: A Randomized Pilot Trial (STEPS-CI) | Mary Janevic, University of Michigan | STEPS-CI, a community health worker-led chronic pain self-management program designed to improve pain-related outcomes for older adults with chronic pain and mild to moderate cognitive impairment | Older adults who report chronic musculoskeletal pain and mild to moderate cognitive impairment (Ages 50+) | 2026 |
| Deprescribing for Post-Acute Care Older Patients with Dementia in Home Health Care | Deprescribing for Post-Acute Care Older Patients with Dementia in Home Health Care | Jinjiao Wang, University of Rochester | The HomeMed- Antipsychotic dePrescribing for Dementia (HomeMed-APD) intervention which includes 3-4 (or more) home visits delivered by home health care nurses to deprescribe certain medications | Older adults with Alzheimer's disease or related dementia (Ages 65+), and their care providers (Ages 18+). | 2029 |
| Caregiver-assisted pain coping skills training for dementia | Caregiver-assisted Pain Coping Skills Training for Dementia | Laura Porter, Duke University | Caregiver-assisted pain coping skills intervention for patient-caregiver dyads to provide training in behavioral skills for pain management | People with mild-moderate dementia and chronic pain (Ages 50+) and their caregivers (Ages 18+) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Training the Long-Term Services and Supports Dementia Care Workforce in Provision of Care to Sexual and Gender Minority Residents | MN Inclusive LTSS for LGBTQ Seniors (MILLS) | B. R. Simon Rosser, University of Minnesota Twin Cities | Training To Serve (TSS) Curriculum: provides resources and training for long-term services and supports (LTSS) providers;Online Equivalent Intervention (eTTS): TTS will be translated using e-learning best practices. Additions will include new optional modules.Waitlist Control: Those assigned to the waitlist control complete baseline surveys and then, following randomization, wait for 6 months before training. | Long-term services and support staff (Ages 18+), Sexual and Gender Minority (SGM) residents, and SGM resident caregivers | 2026 |
| Improving Information Sharing Between Family Caregivers and Home Care Aides Caring for Persons Living with ADRD | Information Sharing Between Family Caregivers and Home Care Aides Caring for Persons Living with ADRD | Chanee Fabius, Johns Hopkins Bayview Medical Center | A feasibility test of a home care role and preference guide designed to improve information sharing between family caregivers and home care aides of persons living with Alzheimer's disease and related dementias (AD/ADRD) receiving Medicaid Home and Community-Based Services in Maryland | Family caregivers and home care aides of older adults living with Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Aging Brain Care Virtual Program (ABCV) | Alexia Torke, Indiana University | Virtual collaborative care program to reduce emergency department utilization and the secondary outcomes of medication use | Persons living with dementia (Ages 65+) and their care partners (Ages 18+) | 2025 |
| Engage-D: DEsigNing Culturally Sensitive Care ManaGement for Hospice TrAnsitions for Diverse Persons LivinG with AdvancEd Dementia | Engage-D: DEsigNing Culturally Sensitive Care ManaGement for Hospice TrAnsitions for Diverse Persons LivinG with AdvancEd Dementia | Komal Murali, New York University | A checklist intervention to better understand how to deliver culturally sensitive care management for hospice care transitions involving racially and ethnically diverse persons living with the dementia and their care partners | Persons living with dementia and their care partners (Ages 18+) | 2028 |
| Skipping the hospital: acute hospital care at home for people living with dementia | Skipping the Hospital: Acute Hospital Care at Home for People Living with Dementia | David Levine, Brigham & Women's Hospital | Acute hospital care at home pathway intervention to improve the care provided to people living with dementia, both prior to and when they become acutely ill | Adults with moderate or severe dementia and their adult caregivers (Ages 18+) | 2029 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Indiana Palliative Excellence in Alzheimer Care Efforts-RCT | Indiana Palliative Excellence in Alzheimer's Care Efforts (IN-PEACE) | Greg Sachs, Indiana University-Purdue University Indianapolis | Palliative care to improve the care of community dwelling patients with dementia and their family caregivers through an innovative model of supportive care that combines an existing, evidence-based intervention for dementia care with an innovative intervention | People with moderate to severe stage dementia (Ages 65+) | 2025 |
| Transforming Residential Palliative Care for Persons with Dementia Through Behavioral Economics and Data Science (Pilot) | Pilot Study of an Advance Care Planning Intervention Among Persons With Dementia | Donald Sullivan, Oregon Health and Science University | Education information sheet for the promotion of advanced care planning (ACP) among family members of persons with advanced dementia in long-term services and support facilities | Clinicians and family members of persons with advanced dementia in long-term services and support facilities | 2025 |
| Enhanced Dementia Instruction and Tool in Home Hospice Care (EDITH-HC) | Pilot Testing Dementia-Enhanced Training and Tool for Home Hospice Clinicians (EDITH-HC) | Elizabeth Luth, Rutgers Biomedical And Health Sciences | Training program and tool to improve clinicians' knowledge of dementia-related challenges in home hospice care, reduce family caregiver burden, and reduce hospice disenrollment | Nurses or social workers who provides home hospice to persons living with dementia and family caregivers | 2025 |
| Palliative Care Needs and Outcomes for Dementia Patients | Supportive Care for Cognitively Impaired Patients and Families | Vyjeyanthi S. Periyakoil, Stanford University | Nurse-led early palliative care intervention (EPC) involving conducting systematic assessment and providing coaching to patients to improve care and well-being | Community-dwelling Stanford ADRC participants (Ages 60 - 100) | 2025 |
| Palliative Care for Persons with Late-stage Alzheimer's and Related Dementias and their Caregivers: A Randomized Clinical Trial | Palliative Care for Persons With Late-stage Alzheimer's and Related Dementias and Their Caregivers (ADRD-PC) | Laura Hanson, University of North Carolina at Chapel Hill | Dementia-specific palliative care intervention involving caregiver education and transitional care | Dyads of hospitalized patients with late stage Alzheimer's disease and related dementias (AD/ADRD) and their family caregivers | 2025 |
| UPLIFT-AD (Utilizing Palliative Leaders in Facilities to Transform Care for Alzheimer's Disease) Intervention | Utilizing Palliative Leaders In Facilities to Transform Care for Alzheimer's Disease (UPLIFT-AD) | Kathleen Unroe, Indiana University-Purdue University Indianapolis | Palliative care intervention utilizing palliative care champions to consult and help surrogate decision makers | Surrogate decision makers for persons living with dementia in nursing homes | 2025 |
| LEADing End-of-Life Dementia Care Conversations | LEADing Dementia End-of-Life Planning Conversations (LEAD) | Kara Dassel, University of Utah | Tool to help persons with preclinical awareness of Alzheimer's disease and related dementia risk and those with early-stage cognitive impairment to begin advance care planning conversations with a care partner | Community-dwelling pairs consisting of persons in the preclinical or early stage of Alzheimer's disease and related dementia (AD/ADRD) and their care partner | 2027 |
| Palliative Care at Home for Patients With Dementia | Palliative Care at Home for Patients with Dementia | Nathan Goldstein, Icahn School of Medicine at Mount Sinai | A new novel home-based palliative care intervention for patients with advanced AD/ADRD and their caregivers. Dyads will be cared for by a pyramid of palliative care and dementia care trained providers who will continue to work with the patient / caregiver through face-to-face visits, video visits, and (at least) weekly phone calls for 12 months | Older adults (ages 65+) with advanced dementia, based on Global Deterioration Score (GDS) >6 who are impairment in at least one activity of daily living (ADL) and their family caregiver | 2027 |
| A Novel Intervention to Improve Care for Older Sexual and Gender Minority (SGM) Adults with Serious Illness and Especially Those with Alzheimer's and Related Dementias (ADRD) | Intervention to Collect and Utilize Sexual Orientation and Gender Identity (SOGI) Information in Hospice | Carey Candrian, University of Colorado Anschutz Medical Campus | 1) Stakeholder-based behavioral intervention: trains hospice interdisciplinary staff in person-centered communication to promote authentic end-of-life care for sexual and gender minority patients (SGM) patients; and 2) Communication training intervention: teaching hospice interdisciplinary staff to sensitively collect and incorporate sexual orientation and gender identity (SOGI) data to more effectively communicate to accomplish assessment and person-centered care when providing end of life | Hospice interdisciplinary team (IDT) staff, sexual and gender minority (SGM) former/current patients, and SGM older adults current/former caregivers for people living with Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| Transforming Residential Palliative Care for Persons with Dementia Through Behavioral Economics and Data Science (Pilot) | Translating Data Science to Palliative Care | Elizabeth Luth, Rutgers Biomedical And Health Sciences | Enhanced palliative care communication strategies and clinician workflow intervention to alter patients’ and family care partners’ engagement with palliative care | Persons living with dementia (Ages 18+) | 2025 |
| Preparing Assisted Living Staff to Care for Persons with Dementia: Palliative Care Education in Assisted Living for Dementia Care Providers | Preparing Assisted Living Staff to Care for Persons with Dementia: Palliative Care Education in Assisted Living for Dementia Care Providers | Debra Dobbs, University of South Florida (USF) | A palliative care education intervention aimed to improve quality of dementia care outcomes, staff process outcomes and family satisfaction outcomes | Staff, residents and family members (Ages 21+) of assisted living communities | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Adapting an Evidence-Based Program that Improves Oral Hygiene and Health for Assisted Living Residents with Dementia | Oral Hygiene in Assisted Living - Aim 2 | Sheryl Zimmerman, University of North Carolina at Chapel Hill | A program to provide daily mouth care to reduce bacteria in the mouth that can lead to aspiration pneumonia for assisted living residents | Residents with dementia, care staff, and dental hygienists (Ages 18+) | 2024 |
| Changing Talk Online Training (CHATO): A National Trial to Reduce Behavioral Symptoms in Long Term Care Residents with Alzheimer's Disease and Other Dementias | Changing Talk Online Training (CHATO) National Trial | Kristine N. Williams, University of Kansas Medical Center | Elderspeak and communication training to reduce behavioral symptoms in long term care settings | Nursing home staff | 2026 |
| Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce | Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce | Sheryl Zimmerman, University of North Carolina at Chapel Hill | Two training arms (essentiALZ alone and essentiALZ + ECHO) in terms of adoption, reach, and reaction. The trial will determine effectiveness of two training arms in relation to each other and to a control arm | Staff at Assisted Living facilities | 2027 |
| Improving Health Equity in Long-term Care Residents with Dementia: The Role of Race and Ethnicity in Resident-to-Resident Aggression | Improving Health Equity in Long-Term Care Residents with Dementia: The Role of Race and Ethnicity in Resident-to-Resident Aggression | E-Shien Chang, Joan and Sanford I Weill Medical College of Cornell University | A new staff education module aimed to prevent and mitigate race/ethnicity-related resident-to-resident aggression in long-term care facilities | Nursing home healthcare providers (Ages 18+) | 2028 |
| Adapting an Evidence-Based Program that Improves Oral Hygiene and Health for Assisted Living Residents with Dementia | Oral Hygiene in Assisted Living - Aim 3 | Sheryl Zimmerman, University of North Carolina at Chapel Hill | A program to provide daily mouth care to reduce bacteria in the mouth that can lead to aspiration pneumonia for assisted living residents | Residents with dementia, care staff, and dental hygienists (Ages 18+) | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology (Pilot) | Self-Care for Dementia Caregivers: User-Centered Design | Sarah Stahl, University of Pittsburgh | iCARE is a multicomponent intervention that uses mobile technology and motivational health coaching to optimize behaviors that keep the body’s biological clock in sync: sleep, exercise, and social activities | Caregivers of persons living with dementia | 2025 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology (Pilot) | Protecting Alzheimer's Caregivers Using Technology Through Staying Sharp (PROACTS) | Chao-Yi Wu, Oregon Health and Science University | Staying Sharp, an online multi-component health intervention to promote a healthier lifestyle and improved skills for coping with the stress involved in dementia caregiving | Caregivers of persons with Alzheimer's disease and related dementias (AD/ADRD) | 2025 |
| Motor Learning of Fall Resistant Skills from Laboratory-Induced Falling Among People with Alzheimer's Disease | Perturbation Training Reduces Falls in People With AD (STAD) | Feng Yang, Georgia State University | Perturbation training, a motor learning intervention to prevent falls | Older adults with mild Alzheimer's disease | 2025 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology (Pilot) | Neighborhood-based Physical and Social Activity for Older Black Caregivers and People Living With Dementia (SHARP-CG) | Raina Croff, Oregon Health and Science University | The SHARP Android application preloaded with 72 GPS-linked routes, each route with three “Memory Markers” (historical localized images with two associated questions) designed to prompt conversational reminiscence about local Black history, culture, and life experiences while walking | Triads of 1) primary caregiver, 2) caregiver support person, and 3) African American person with early-stage dementia | 2025 |
| Reducing Loneliness of Older Adults in Long Term Care Facilities through Collaborative Augmented Reality | Reducing Loneliness of Older Adults in Long Term Care Facilities Through Collaborative Augmented Realities | Nilanjan Sarkar, Vanderbilt University | HMD-AR, a collaborative head mounted display augmented reality to maximize social connection and engagement | Older adults residing in LTC facilities, family members of the older adults, and formal staff caregivers employed in the Department of Recreational Activities | 2025 |
| Effectiveness and Adoption of a Smart Home-based Social Assistive Robot for Care of Individuals with Alzheimer's Disease | Social Assistive Robot for Care of Individuals with Alzheimer's Disease | Sajay Arthanat, University of New Hampshire | Mobile Assistive Robot with Smart Sensing (MARSS) is a smart home-based social assistive robot with multi modal care protocols which combines best practices and existing research on home automation, human-robot interaction, and Alzheimer's disease care giving | Individuals with Alzheimer’s diseases and caregiver dyads | 2027 |
| Telehealth-Enhanced Patient-oriented Recovery Trajectory After Intensive Care | Telehealth-enhanced Patient-oriented Recovery Trajectory After Intensive Care (TelePORT) | Leanne Boehm, Vanderbilt University | Collaborative telemedicine-delivered ICU-Recovery Clinic intervention to identify and improve long-term cognitive impairment, physical and mental health dysfunction, social integration, and self-management behaviors for older critically ill adults | Older adults treated in a medical or surgical ICU for acute respiratory failure and/or septic shock and at high risk for developing Post-Intensive Care Syndrome (Ages 45+) | 2028 |
| A Light Exposure Tracker Designed to Improve the Circadian Entrainment for Alzheimer's Disease Patients | A Light Exposure Tracker Designed to Improve Circadian Rhythms - Aim 1 | Erik Page, Blue Iris Labs, Inc. | Speck Sr., an active lighting intervention designed to add morning light and reduce evening light to optimize light exposure and support circadian entrainment | Healthy older adults | 2025 |
| Over-The-Counter Hearing Aid Treatment for Adults with Cognitive Decline Due to Alzheimer's Disease and Related Dementias | OTC Hearing Aid and MCI | Pamela Souza, Northwestern University | Hearing or communication intervention to improve cognition and overall communication ability | Adults with mild hearing loss and early-stage Alzheimer's disease, related dementia, or mild cognitive impairment (Ages 60+) | 2025 |
| Smartphone-based Solutions for Prospective Memory in Mild Cognitive Impairment and Dementia | Paper-Based and Smartphone-Based Memory Supports | Michael Scullin, Baylor University | Prospective memory training for persons with mild cognitive impairment or mild dementia using smart-phone based strategies | People with mild cognitive impairment or mild dementia from underserved or digitally disadvantaged populations and their study partners | 2028 |
| The BRAIN App: Building Relationships Using Artificial Intelligence and Nostalgia | The BRAIN App: Building Relationships Using Artificial Intelligence and Nostalgia | Michael Skrajner, Hopeful Aging LLC | BRAIN APP is a non-pharmacological intervention that provides person-centered activities for persons with dementia through the use of Artificial Intelligence | Persons living with dementia (Ages 65+) and professional care partners and family members (Ages 18+) | 2025 |
| LifeBioTALK: Digital Engagement with a Pre-Scripted Avatar for People with Alzheimers Disease to Reduce Challenging Behaviors and Caregiver Burden | LifeBioTALK: Digital Engagement with a Pre-Scripted Avatar for People with Alzheimer's Disease to Reduce Challenging Behaviors and Caregiver Burden | Lisbeth Sanders, LifeBio Inc | LifeBioTALK, a pre-planned, avatar-led, automated social support engine that delivers engaging content to lessen the impact of behavioral and psychological symptoms of dementia | People living with dementia (Ages 65+) and their caregivers (Ages 18+) | 2025 |
| Active-H2O: Sensor driven smart faucet to empower independent living for individuals impacted by Alzheimers disease and dementia | Active-H2O: Sensor Driven Smart Faucet to Empower Independent Living for Individuals Impacted by Alzheimer's Disease and Dementia | John Waddell, Nasoni Llc | An intervention developed to improve access to water and independence of activities of daily living requiring water for those with Alzheimer’s disease or dementia | Individuals with mild and moderate dementia (Ages 50+) and their caregivers (Ages 18+) | 2026 |
| Onward Door-Through-Door Companion Rideshare Technology to Improve Care for Older Adults and Individuals with Alzheimers Disease and Related Dementias (AD/ADRD) | Onward Door-Through-Door Companion Rideshare Technology to Improve Care for Older Adults and Individuals with Alzheimer's Disease and Related Dementias (AD/ADRD) | Kimberly Wachter Petty, Onward Health, Inc | A rideshare service intervention developed to create a marketplace for healthcare transportation and a system for enabling door-through-door companion rideshare services | Older adults, including those with cognitive impairments (Ages 55-89) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Promoting Seniors Health with Home Care Aides: A Randomized Controlled Trial | Promoting Seniors' Health With Home Care Aides | Naoko Muramatsu, University of Illinois at Chicago | Healthy Moves for Aging Well (Healthy Moves), a safe physical activity program delivered by home care aides, which consists of a brief motivational enhancement and three movements to be performed in a seated position | Pairs of eligible patients and their home care aides | 2024 |
| Pragmatic Trial of the Effectiveness and Cost-Effectiveness of Dementia Care | D-CARE - The Dementia Care Study: A Pragmatic Clinical Trial of Health System-Based Versus Community-Based Dementia Care (D-CARE) | David Reuben, University of California Los Angeles | Pragmatic intervention to compare clinical effectiveness and cost-effectiveness of community-based dementia care and health system-based care | Dyads of persons with dementia and their primary caregivers (Ages 18+) | 2025 |
| PLAN: Dementia Literacy Education and Navigation for Korean Elders with Probable Dementia and their Caregivers | PLAN: Dementia Literacy Education and Navigation for Korean Elders With Probable Dementia and Their Caregivers (PLAN) | Hae-Ra Han, Johns Hopkins Bayview Medical Center | PLAN, a dementia literacy training used to train community health workers to improve caregiver's dementia literacy, self-efficacy in dementia care and service use, social support, depression, and quality of life | Community health workers and dyads of individuals with probable dementia (Ages 65+) and their caregiver (Ages 18+) | 2025 |
| Behavioral Change Following Culturally-Informed Biomarker Disclosure in Alzheimer’s Disease | Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure (SHARED III) | Annalise Rahman-Filipiak, University of Michigan | Diagnostic Disclosure Protocol, where participants receive information about current cognitive performance to assess long-term behavior, safety, and efficacy in patients with amnestic Mild Cognitive Impairment (aMCI) following biomarker disclosure | Adults diagnosed with amnestic mild cognitive impairment within the past 12 months (Ages 50+) | 2026 |
| Primary Care Based Collaborative Approach to Care Management for Older Adults with Dementia | Primary Care Based Collaborative Approach to Care Management for Older Adults with Dementia | Stephanie Nothelle, Johns Hopkins Bayview Medical Center | Develop and implement a practical primary care based intervention to facilitate collaboration across care management programs | Older adults with Alzheimer's disease and related dementia (AD/ADRD) | 2026 |
| Natives Engaged in Alzheimer's Research | Indians Transforming Alzheimer's Care Training (INTACT) | Patrik Johansson, Washington State University | INTACT, a clinic-level intervention to improve Alzheimer's disease and related dementias diagnosis and quality of care for American Indian and Alaska Natives | Rural clinics serving American Indian and Alaska Natives | 2026 |
| Multi-Stakeholder Engagement for Interdisciplinary Telehealth in Lewy Body Dementia | Telehealth in Lewy Body Dementia | Bhavana Patel, University of Florida | Telemedicine model of Lewy Body Dementia interdisciplinary care | Individuals living with Lewy Body Dementia and their caregivers | 2026 |
| A Novel Platform to Facilitate Provider Adoption of Cognitive Care Planning | The Impact of BrainCheck Care on Physical and Emotional Health of Patients and Caregivers | Bin Huang, Braincheck, Inc. | BC-Care (BrainCheck), a cognitive care planning tool that integrates patient, provider, and caregiver input to generate personalized Alzheimer's disease and related dementias (AD/ADRD) recommendations and follow-up care to be implemented during an AD/ADRD's patient's medical visit | Adults with an existing diagnosis of mild to moderate dementia (Ages 65+), their caregiver, and their health care provider | 2025 |
| Effect of Acetylcholinesterase Inhibitors on Bone Metabolism and Fracture Risk Factors Among Older Adults with Mild to Moderate Alzheimer's Disease | Effect of Acetylcholinesterase Inhibitors on Bone Metabolism | Richard Lee, Duke University | Donepezil, an acetylcholinesterase inhibitor, compared to placebo to measure the effect on fracture risk factors including bone mineral density (BMD), bone turnover markers, and bone quality | Older adults with biomarker-diagnosed Alzheimer’s disease and related dementias at the Duke Memory Disorders Clinic | 2025 |
| A Pilot of Memory Support System for Older Chinese Americans with Mild Cognitive Impairment | A Pilot of Memory Support System for Older Chinese Americans with Mild Cognitive Impairment | Clara Li, Icahn School of Medicine at Mount Sinai | Chinese adapted memory support system that uses a day planner and note-taking system as a support tool to train individuals with mild cognitive impairment to perform their instrumental of activities of daily living independently | Chinese American older adults (Ages 65+) and their care partners who are primarily Mandarin and Cantonese-speaking | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Deprescribing Potentially Inappropriate Medications in the Emergency Department for Persons Living with Dementia (IMPACT) | Scott Dresden, Northwestern University | Deprescribing recommendations and monitoring of medication supply data for the reduction of potentially inappropriate medications use | Emergency department patients with diagnosed Alzheimer’s disease and related dementias or mild cognitive impairment | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | Deprescribing in Patients Living with Dementia with Caregiver and Provider Nudges | Julie Lauffenburger, Brigham and Women's Hospital | Electronic health record deprescribing to facilitate deprescribing of high-risk medications | Primary care providers, patients living with dementia or mild cognitive impairment and their care partners | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory (Pilot) | ALIGN: Aligning Medications With What Matters Most (Demonstration) | Ariel Green, Kaiser Permanente Colorado | Pharmacist-led deprescribing intervention in primary care to optimize medication usage by reducing or stopping medications that are harmful or unlikely to be beneficial | People living with dementia (Ages 65+) | 2025 |
| Helping Patients, Families, and Clinicians Make Shared Decisions about Therapies for Dementia | Helping Patients, Families, and Clinicians Make Shared Decisions about Therapies for Dementia | Daniel Matlock, University of Colorado Anschutz Medical Campus | A decision aid intervention on patients and their clinicians considering pharmacologic therapy for dementia, to improve a) the feasibility and acceptability of the decision aid, and b) its preliminary efficacy on knowledge, decision conflict, and other implementation outcomes | Older adult (Ages 60+) patients with documented neurocognitive deficits suggestive of mild cognitive impairment or early dementia, and caregivers (Ages 18+) | 2026 |
| Project GLORY: Good Life in memORY care | Promoting the Good Life among Nursing Home Residents with Dementia | Jessica Benfer, Wisconsin Evangelical Lutheran Synod Kingdom Workers, Inc | The proposed intervention is “Good Life” which is a model of care designed to improve outcomes and enhance resident well-being/quality of life | Nursing home residents with Alzheimer's disease and related dementia (AD/ADRD), family members, and staff caring for residents with Alzheimer's disease and related demantias | 2028 |
Section 5: Understanding Disease Processes
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Fatty Acid Modulation of Brain Function in Older Adults | Fatty Acid Modulation of Brain Function in Older Adults | Julie Dumas, University of Vermont and State Agricultural College | Testing the effect of dietary fat on working memory | Cognitively normal men and women with a healthy body mass index of 20 to 40 kg/m2 (Ages 65 - 75) | 2028 |
| Time Restricted Eating for Prevention of Age-related Vascular Cognitive Decline in Older Adults | The Effect of Intermittent Fasting on Brain Health | Andriy Yabluchanskiy, University of Oklahoma | Time restricted eating intervention to improve neurovascular function and cognitive performance | Older adults (Ages 55 - 80) | 2025 |
| Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder | Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder | Michael Howell, University of Minnesota Twin Cities | Compare serotonergic rapid eye movement (REM) sleep Behavior Disorder (5-HT RBD) participants and to adults without RBD who are taking a serotonergic antidepressants in order to: (1) detect systemic alpha-synuclein pathology; (2) examine for evidence of brainstem neurodegeneration using 7T magnetic resonance imaging; (3) quantify evolving speech deficits | Adults with serotonergic rapid eye movement (REM) sleep Behavior Disorder (5-HT RBD) and adults without RBD who take serotonergic antidepressants (Ages 18 - 75) | 2028 |
| Attentional Mechanisms of Cognitive Compensation in Subjective Cognitive Decline and AD Risk | Attentional Mechanisms in SCD (AMoCC-SCD) | Kimberly Albert, Vanderbilt University Medical Center | Mecamylamine, a centrally and peripherally active non-competitive antagonist of acetylcholine at C6 (ganglionic) type nicotinic receptors, to better identify older adults at risk for Alzheimer’s Disease | Community-dwelling Chinese American older adults (Ages 55+) | 2028 |
| Breaking Prolonged Sitting with High-intensity Interval Training to Improve Cognitive and Brain Health in Older Adults | Breaking Sitting With High-intensity Interval Training for Brain Health (HIIT2SITLess) | Dominika Pindus, University of Illinois | Feasibility trial of brief high intensity interval training (HIIT) exercise breaks to interrupt sitting and improve cognitive function | Healthy, sedentary older adults without dementia (Ages 60 - 75) | 2025 |
| Effects of Acute Stress Exposure on Plasma Beta-Amyloid Levels | Acute Alzheimer's Disease Biomarker Responses | Mara Mather, University of Southern California | Measure the plasma beta-amyloid response to an acute laboratory stressor using the socially evaluated cold pressor test (SECPT) to aid in understanding how stress contributes to Alzheimer's disease development and progression in people | Healthy adults (Ages 18 - 65) | 2024 |
| Bilingual Factors Associated with Cognitive Reserve and Linguistic Resilience in Hispanics with Primary Progressive Aphasia | Bilingual Factors Associated with Cognitive Reserve and Linguistic Resilience in Hispanics with Primary Progressive Aphasia | Stephanie Grasso, University of Texas at Austin | Naming intervention for individuals with logopenic or semantic variant primary progressive aphasia (PPA) or script training intervention for individuals with nonfluent/agrammatic PPA | Bilingual individuals with primary progressive aphasia | 2027 |
| Use of 7T Multimodal Imaging to Detect Brain Changes Associated with Light Therapy in Persons with Mild Cognitive Impairment and Mild Alzheimer's Disease | 7T MRI for Light Therapy in Patients With Mild Cognitive Impairment and Mild AD | Priti Balchandani, Icahn School of Medicine at Mount Sinai | High-resolution multi-modal 7T imaging to investigate the impact of lighting intervention therapy (LIT) on sleep physiology and brain structure, function, and connectivity in people with mild cognitive impairment and mild Alzheimer's disease | Amnestic mild cognitive impairment or mild Alzheimer's disease patients with a confirmed Aß+ PET scan | 2025 |
| Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History (PATH) | Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History (PATH) | Christian Lobue, University of Texas Southwestern Medical Center | Mechanistic study using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools | Individuals with amnestic mild cognitive impairment with and without a history of mild traumatic brain injury (TBI) | 2027 |
| Caffeine and Postoperative Neurocognitive Recovery | The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study | Phillip Vlisides, University of Michigan | Test the effects of caffeine on neurocognitive and clinical recovery after major surgery | Adult surgical patients presenting for major non-cardiac, non-intracranial, non-major vascular surgery (Ages 70+) | 2027 |
| Losing Specificity: The Role of the Locus Coeruleus in Age-Related Distractibility | The Role of the Locus Coeruleus in Age-related Distractibility | Tae-Ho Lee, Virginia Polytechnic Institute and State University | Two interventions to facilitate neural plasticity in the brain, either multi-modal adaptive attention training or practice on a training version of the criterion attention task, to examine how this may modulate locus coeruleus-salience network connectivity and mitigate distractibility | Healthy participants from the Roanoke and Blacksburg metropolitan area in Virginia (Ages 55 – 75) | 2027 |
| Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease | Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease (Stress-AD) | Cynthia Munro, Johns Hopkins Bayview Medical Center | Response to an acute stressor (trier social stress test) in mild cognitive impairment | Adults with mild cognitive impairment | 2027 |
| Characterizing and Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging | Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging | Natalie Ebner, University of Florida | Neurofeedback training using real time fMRI to increase activity in the anterior cingulate gyrus to improve learning | Healthy older adults (Ages 60 - 85) | 2027 |
| Resilience and Brain Health of Older Adults During the COVID-19 Pandemic | Resilience and Brain Health of Older Adults During the COVID-19 Pandemic (MEDEX-2) (MEDEX-2) | Eric Lenze, Washington University in St. Louis | Exercise and mindfulness interventions to measure the effects of COVID-induced stress on Alzheimer's disease-related cognitive decline | Healthy, sedentary, community living individuals (Ages 65 - 84) | 2026 |
| APOE Genotype Effects on Triglycerides and Blood Flow in the Human Brain | Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain | Angela Hanson, University of Washington | Ingestion of a high fat drink (heavy dairy cream) to gain a more in-depth understanding of how high fat feeding (HFF) exerts influence on brain function and metabolism for APOE e4 carriers and non-carriers, and identify brain regions which are particularly vulnerable to the acute effects of HFF | Older adults with and without APOE E4 (Ages 55+) | 2025 |
| Quantitative Imaging of Brain Glymphatic Function in Humans | Quantitative Imaging of Brain Glymphatic Function in Humans | Manus Donahue, Vanderbilt University Medical Center | MRI and PET imaging to evaluate levels of beta-amyloid burden and assess lymphatic drainage function | Older adults with Parkinson's disease (Ages 55 - 80) | 2025 |
| Health of the Cholinergic System and Risk for Alzheimer's Disease in Postmenopausal Women | Cholinergic Health After Menopause (CHAMP) | Julie Dumas, University of Vermont and State Agricultural College | Mecamylamine, a cholinergic antagonist, to study the relations between the cholinergic system's functional integrity, cognition, and known Alzheimer's disease biomarkers | Postmenopausal women (Ages 50 - 70) | 2025 |
| Improving Working Memory in Older Adults by Restoring Large-Scale Cortical Interactions | Improving Working Memory in Older Adults | Robert Reinhart, Boston University | High-definition transcranial alternating-current stimulation of the frontal and temporal cortex, to improve working memory and cognition | Younger adults (Ages 18 - 30) and older adults (Ages 68 - 80) | 2025 |
| Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS II) | Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS II) | Oluwaseun Johnson-Akeju, Massachusetts General Hospital | Nighttime dexmedetomidine for post-operative delirium prevention and cognitive improvement in elderly patients following cardiac surgery | Individuals scheduled to undergo a cardiac surgical procedure with cardiopulmonary bypass with planned postoperative admission to the intensive care unit (Ages 60+) | 2029 |
| Type 2 Diabetes Mellitus and Blood Brain Barrier Function Improvement- A Randomized Clinical Trial | Type 2 Diabetes and Blood Brain Barrier Improvement | Rajesh Kumar, University of California, Los Angeles | A low-cost thiamine intervention to repair blood brain barrier function, thus decreasing early dementia and Alzheimer’s disease, reducing morbidity and mortality, and increasing quality of life in adults living with Type 2 diabetes mellitus | Adults living with Type 2 diabetes mellitus (Ages 40-65) | 2026 |
| Optimizing Anesthesia to Prevent Postoperative Cognitive and Functional Decline in Older Adults | Inhalational Anesthesia vs. Intravenous Anesthesia (GASvsIV) | Katie Schenning, Oregon Health and Science University | IV vs. inhalational anesthesia on post-operative delirium, post-operative cognitive dysfunction, functional status, and patient-reported outcomes | Older adults undergoing elective inpatient non-cardiac surgery (Ages 75+) | 2027 |
| Noradrenergic Dysregulation, Sleep and Cognition in Older Adults with Insomnia | Noradrenergic Dysregulation, Sleep and Cognition in Older Adults with Insomnia | Phyllis Zee, Northwestern University, Chicago | Bright light or dim red-light intervention will be used in participants with insomnia to further elucidate the mechanistic dynamics between noradrenergic system activity with sleep quality and cognition in insomnia | Adults (Ages 55+) with insomnia and good sleeper controls | 2029 |
| Mitigating Delirium with Fluvoxamine Treatment for Non-Cardiac Surgery (MD FluNCS): Feasibility Trials & Mechanistic Insights | Mitigating Delirium with Fluvoxamine Treatment for Non-Cardiac Surgery (MD FluNCS): Feasibility Trials & Mechanistic Insights | Ben Palanca, Washington University in St. Louis | Fluvoxamine, a selective serotonin reuptake inhibitor that has anti-inflammatory properties, to reduce delirium incidence and severity | Older adults (Ages 60+) who have scheduled elective non-cardiac non-intracranial surgery and whose planned postoperative hospitalization is at least 2 days | 2026 |
| MAEVE: Microbiota mediated flavonoid metabolites for cognitive health | MAEVE: Microbiota Mediated Flavonoid Metabolites for Cognitive Health | Arpana Church, University of California Los Angeles (UCLA) | Dietary polyphenol intake to alter brain and gut microbial metabolites to support healthy cognitive aging | Older adults at risk for Alzheimer's disease (Ages 50+) | 2029 |
| Grit against cognitive decline in aging and preclinical Alzheimer Disease | Grit Against Cognitive Decline in Aging and Preclinical Alzheimer's Disease | Alexandra Touroutoglou, Massachusetts General Hospital | Repetitive transcranial magnetic stimulation (rTMS) to modulate the functional connectivity of themid-cingulate cortex to increase levels of grit and enhance memory | Amyloid-positive (Aß+) cognitively normal older adults (preclinical AD) and amyloid negative (Aß-) healthy cognitively normal older adults (Ages 65-80) | 2029 |
| A Pilot Study of Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST) | A Pilot Study of Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST) | Lei Gao, Massachusetts General Hospital | A non-invasive app to deliver a previously tested cognitive behavioral therapy intervention for sleep hygiene prior to orthopedic surgery | Older adults (Ages 65+) at Massachusetts General Hospital presenting for major orthopedic surgery with moderate to severe insomnia | 2026 |
| University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC) | Adaptive Working Memory and Physical Exercise Training to Improve Brain and Mitochondrial Fxn in MCI | Linda Chang, University of Maryland, Baltimore (UMB) | Trial will include three intervention groups (progressive aerobic exercise, adaptive cognitive training, or combined progressive aerobic exercise and adaptive cognitive training) to improve cognitive, emotional, motor, and executive function | Adult men and women with mild cognitive impairment (Ages 50-80) | 2026 |
| Serotonin Modulation of Neural Circuitry in bvFTD: Understanding the Neurobiology of Mood and Cognitive Symptoms | Serotonin Modulation of Neural Circuitry in bvFTD: Understanding the Neurobiology of Mood and Cognitive Symptoms | Christopher Morrow, Johns Hopkins Bayview Medical Center (JHBMC) | A Positron Emission Tomography (PET) study to measure glucose metabolism and identify the neural circuitry associated with affective symptoms in behavioral variant frontotemporal dementia with multi-modal antidepressant (Vortioxetine) treatment that targets both serotonin receptors and serotonin transporters | Individuals the behavioral variant of frontotemporal dementia (Ages 45+) | 2029 |
| Age-related Cognitive Changes: Effects of Combined Flavonoid Intake and Physical Exertion Mediated by the Gut Microbiome | Age-related Cognitive Changes: Effects of Combined Flavonoid Intake and Physical Exertion Mediated by the Gut Microbiome | Mary Ann Lila, North Carolina State University | This study aims to combine a flavonoid-rich diet and routine physical activity to potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the gut microbiome | Healthy participants (Ages 65-80) | 2029 |
| Neural Correlates of Cognitive-Motor Interactions in ADRD Gait | Neural Correlates of Cognitive-Motor Interactions in ADRD Gait | Rachael Seidler, University of Florida | The trial will apply bilateral vestibular cortical transcranial direct current stimulation to the vestibular cortex during walking and spatial navigation to investigate if vestibular network segregation can be restored in individuals with subjective cognitive decline | Community dwelling adults with subjective cognitive decline and a family history of dementia/probable Alzheimer's disease in first degree relative (Ages 18-35 or 65-89) | 2029 |
| The Benefits of Nicotinamide Riboside Upon Cognition and Sleep in Older Veterans | Benefits of Nicotinamide Riboside Upon Cognition and Sleep | Carleara Weiss, State University of New York at Buffalo | Nicotinamide riboside (NR) supplementation to enhance cognition by improving objective sleep duration and sleep quality in older persons | Older adults with poor sleep quality (Ages 65 - 85) | 2027 |
| A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients | A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients | Aprinda Queen, University of Florida | Examination and analysis of Transcranial Direct Current Stimulation (tDCS) effect on working memory performance in older adults with mild cognitive impairment | Cognitively healthy older adults and older adults with mild cognitive impairments (Ages 60-95) | 2029 |
Section 6: Diagnostic Tools, Assessments, & Imaging Studies
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Digital Detection of Dementia Studies (D cubed Studies) | Digital Detection of Dementia (D Cubed) Studies: D3 | Malaz Boustani, Indiana University-Purdue University Indianapolis | The Passive Digital Marker (PDM), a Machine Learning (ML) algorithm, and the Quick Dementia Rating Scale (QDRS), a patient reported outcome (PRO) tool, to detect cognitive impairment and improve the annual rate of new documented Alzheimer's disease and related dementias (AD/ADRD) diagnosis in primary care practices | Eligible primary care clinics within the UMiami Health system and adults with at least one visit to a primary care physician within the past year (Ages 65+) | 2025 |
| Digital Detection of Dementia Studies (D cubed Studies) | Digital Detection of Dementia (D Cubed) Studies: D2 | Malaz Boustani, Indiana University-Purdue University Indianapolis | The Passive Digital Marker (PDM), a Machine Learning (ML) algorithm, and the Quick Dementia Rating Scale (QDRS), a patient reported outcome (PRO) tool, to detect cognitive impairment and improve the annual rate of new documented Alzheimer's disease and related dementias (AD/ADRD) diagnosis in primary care practices | Eligible primary care clinics within the Eskenazi Health system and adults with at least one visit to a primary care physician within the past year (Ages 65+) | 2025 |
| Biomarker Predictors of Memantine Sensitivity in patients with Alzheimer's Disease | Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease | Neal Swerdlow, University of California San Diego | Identify sensitivity levels of memantine, an NMDA receptor antagonist approved for treatment of moderate-to-severe Alzheimer's disease | Older adults with Alzheimer's disease | 2025 |
| Emergency General Surgery Delirium Recovery Model: A Collaborative Care Intervention | Delirium and Neuropsychological Recovery Among Emergency General Surgery Survivors | Ben Zarzaur, University of Wisconsin - Madison | Emergency General Surgery Delirium Recovery Program, a care collaborative program to cognitive, functional and psychological recovery after episode(s) of delirium | Surgery patients who suffer at least one episode of delirium in the post-operative period (Ages 65+) | 2027 |
| Evaluating Cognitive Impairment as a Moderator of Locomotor Learning in Older Adults Post-stroke | Cognition and Motor Learning Post-stroke | Kristan Leech, University of Southern California | Biomechanical analyses, neuropsychological assessments, and brain imaging techniques to examine the structural integrity of the dorsolateral prefrontal cortex in explicit locomotor learning and inform the development of a gait rehabilitation intervention for older adults post-stroke | Older adults with post-stroke cognitive impairment | 2026 |
| Identifying and Supporting Patients with Undiagnosed Dementia Using the EHR Risk of Alzheimer's and Dementia Assessment Rule (eRADAR): A Pilot Clinical Trial | The Brain Health Study: A Pragmatic, Patient-Centered Trial | Sascha Dublin, Kaiser Foundation Hospitals - Washington | EHR dementia screening tool to follow up with high risk patients with potential undiagnosed dementia | Older adults enrolled in Kaiser Washington or UCSF care within the past 2 years with no prior diagnosis of dementia (Ages 65+) | 2025 |
| Low-cost Detection of Dementia Using Electronic Health Records Data: Validation and Testing of the eRADAR Algorithm in a Pragmatic, Patient-centered Trial | The Brain Health Study: A Pragmatic, Patient-Centered Trial | Sascha Dublin, Kaiser Foundation Hospitals - Washington | Electronic health record (EHR) dementia screening tool to detect cognitive impairment | Older adults enrolled in Kaiser Washington or UCSF care within the past two years with no prior diagnosis of dementia (Ages 65+) | 2026 |
| ToolBox Detect: Low Cost Detection of Cognitive Decline in Primary Care Settings | ToolBox Detect: Low Cost Detection of Cognitive Decline in Primary Care Settings | Cindy Nowinski, Northwestern University | Cognitive assessment toolbox to detect cognitive decline in Medicare Annual Wellness visits. | Older Adults/Patients (Ages 65+) | 2026 |
| Using Routine Care Electronic Medical Record Data and Artificial Intelligence to Develop a Passive Digital Marker to Predict Postoperative Delirium | Using EMR Data and AI to Develop a Passive Digital Marker to Predict Postoperative Delirium | Sanjay Mohanty, Indiana University-Purdue University Indianapolis | Test a clinical decision support tool incorporating a Passive Digital Marker (PDM) that predicts postoperative delirium based on EHR data and machine learning techniques for feasibility, acceptability, and effect size | Patients scheduled for elective major abdominal surgery requiring inpatient stay of more than 24 hours (Ages 50+) | 2027 |
| A Cognitive Risk Calculator and Screening tool for Primary Care Settings | A Cognitive Risk Calculator and Screening Tool for Primary Care Settings | Darlene Floden, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University | Cognitive screening tools (EHR-based Cognitive Risk Calculator and iPad-based Brief Assessment of Cognitive Health) used in primary care settings to detect dementia | Providers caring for patients (Ages 60+) | 2025 |
| A Technology-Driven Intervention to Improve Early Detection and Management of Cognitive Impairment | A Technology-Driven Intervention to Improve Early Detection and Management of Cognitive Impairment (CI Wizard) | Leah Hanson, HealthPartners Institute | Electronic health record (EHR) cognitive impairment clinical decision support tool to improve early detection and management of cognitive impairment | Patients with elevated dementia risk | 2025 |
| READI-SET-GO: Researching Efficient Approaches to Delirium Identification - Sustaining Effective Translation to create Gero-friendly Organizations | Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation (READI-SET-GO) | Donna Fick, Pennsylvania State University | Daily nurse-led delirium screening using the Ultra-brief Confusion Assessment Method in routine care among all hospitalized older adults to inform best practices for delirium identification, including in vulnerable individuals such as those with Alzheimer’s disease and related dementias | Adults, including a subgroup of participants with Alzheimer’s disease and Alzheimer’s related dementia, with an expected hospital length of stay of 3 or more days (Ages 70+) | 2028 |
| Cognitive Screening Made Easy for Primary Care Providers | Cognitive Screening Made Easy for PCPs - R33 Phase | Robin Hilsabeck, University of Texas at Austin | Cognitive screening tool (RACS app) for primary care providers to conduct cognitive screenings on a regular basis | Cognitively normal and cognitively impaired adults (Ages 60+) | 2026 |
| Novel Methods for Clinical Trials in Dementia and Cognitive Decline | d in Dementia Clinical Trials (dND) | Donald Royall, University of Texas Health Science Center at San Antonio | Donepezil, a cholinesterase inhibitor, to measure the impact on the latent dementia severity metric, and Adipokines, inflammatory proteins, to test the effects of donepezil on the latent dementia severity metric | People with Alzheimer's disease or mild cognitive impairment (Ages 65 – 100) | 2028 |
| Leveraging Electronic Health Records for Reducing Dementia Screening Disparities in Diverse Communities | Leveraging Electronic Health Records for Reducing Dementia Screening Disparities in Diverse Communities | Narges Razavian, New York University School of Medicine | Electronic health records/artificial intelligent predictive model used to improve Alzheimer’s disease and related dementias screening rates and early diagnosis and healthcare metrics related to cognitive health | Primary care providers and patients at high risk for mild cognitive impairment or Alzheimer’s disease and related dementias | 2028 |
| API A4 Alzheimers Prevention Trial | Evaluation of Self-Mediated Alternatives for Risk Testing Education and Return of Results (eSMARTER) | Jessica Langbaum, Banner Alzheimer's Institute | Aducanumab, anti-amyloid plaque antibody treatment, to prevent the onset of Alzheimer's disease | Older adults (Ages 60 - 80) | 2025 |
| Use of novel fluorescent tracers to develop a comprehensive retinal biomarker database that maps the heterogeneity of Alzheimers pathogenesis | Use of Novel Fluorescent Tracers to Develop a Comprehensive Retinal Biomarker Database that Maps the Heterogeneity of Alzheimer's Pathogenesis | Stella Sarraf, Amydis Diagnostics Inc. | Trial aims to develop a new diagnostic technology in retinal tracing (AMDX-2011P) that focuses on the biomarker Aß in patient's with Alzheimer's disease | Individuals with a diagnosis of Alzheimer's disease and healthy adults | 2025 |
| Returning AD biomarker Results to Community Dwelling Older Adults: Testing Modalities and Impact | Returning AD Biomarker Results to Community Dwelling Older Adults: Testing Modalities and Impact | Jessica Mozersky, Washington University in St. Louis | Returning research results that indicate risk of Alzheimer's disease dementia to participants to evaluate the impact on psychosocial, cognitive, and comprehension outcomes | Cognitively normal older adults (Ages 65+) who have had Alzheimer's disease biomarker testing within the past 2 years | 2029 |
Section 7: Treatments for Neuropsychiatric Symptoms
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Randomized Controlled Trial of Electroconvulsive Therapy Plus Usual Care Versus Simulated-ECT plus Usual Care for the Acute Management of Severe Agitation in Alzheimer's Dementia (ECT-AD) | Electroconvulsive Therapy (ECT) for Agitation in Alzheimer's Dementia (AD) | Brent Forester, McLean Hospital | Electroconvulsive Therapy to treat severe agitation in moderate to severe stage Alzheimer's disease | People with moderate to severe stage Alzheimer's disease (Ages 55+) | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Lifes end Benefits of CannaBidol and TetrahYdrocannabinol (LiBBY) Trial | Life's End Benefits of Cannabidiol and Tetrahydrocannabinol (LiBBY) | Jacobo Mintzer, Medical University of South Carolina | Cannabidol and Tetrahydrocannabinol, Cannabis chemotypes, to improve quality of life in adults with Alzheimer's disease | Adults with Alzheimer's disease | 2025 |