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Transcriptional Responses in Disease Group
- Xu J, Watts JA, Pope SD, Gadue P, Kamps M, Plath K, Zaret KS, Smale ST. 2009. Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells.Genes Dev23(24):2824-2838. [ AbstractXu J, Watts JA, Pope SD, Gadue P, Kamps M, Plath K, Zaret KS, Smale ST. 2009. Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes Dev 23(24):2824-2838. ]
- Watts JA, Zhang C, Klein-Szanto AJ, Kormish JD, Fu J, Zhang MQ, Zaret KS. 2011. Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development.PLoS Genet; doi: 10.1371/journal.pgen.1002277 [Online 15 September 2011]. [ AbstractWatts JA, Zhang C, Klein-Szanto AJ, Kormish JD, Fu J, Zhang MQ, Zaret KS. 2011. Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development. PLoS Genet; doi: 10.1371/journal.pgen.1002277 [Online 15 September 2011]. ]
- Grunseich C, Wang IX, Watts JA, Burdick JT, Guber RD, Zhu Z, Bruzel A, Lanman T, Chen K, Schindler AB, Edwards N, Ray-Chaudhury A, Yao J, Lehky T, Piszczek G, Crain B, Fischbeck KH, Cheung VG. 2018. Senataxin mutation reveals how R-loops promote transcription by blocking DNA methylation at gene promoters.Mol Cell69(3):426-437.e7. [ AbstractGrunseich C, Wang IX, Watts JA, Burdick JT, Guber RD, Zhu Z, Bruzel A, Lanman T, Chen K, Schindler AB, Edwards N, Ray-Chaudhury A, Yao J, Lehky T, Piszczek G, Crain B, Fischbeck KH, Cheung VG. 2018. Senataxin mutation reveals how R-loops promote transcription by blocking DNA methylation at gene promoters. Mol Cell 69(3):426-437.e7. ]
- Watts JA, Burdick J, Diagneault J, Bruzel A, Zhu Z, Grunseich C, Cheung VG. 2019. Cis elements that mediate RNA polymerase II pausing regulate human gene expression.Am J Hum Genet105(4):677-688. [ AbstractWatts JA, Burdick J, Diagneault J, Bruzel A, Zhu Z, Grunseich C, Cheung VG. 2019. Cis elements that mediate RNA polymerase II pausing regulate human gene expression. Am J Hum Genet 105(4):677-688. ]
- Watts JA, Grunseich C, Rodriguez Y, Liu Y, Li D, Burdick JT, Bruzel A, Crouch RJ, Mahley RW, Wilson SH, Cheung VG. A Common Transcriptional Mechanism Involving R-loop and RNA Abasic Site Regulates an Enhancer RNA of APOE.Nucleic Acids Research. December 2022. PMID: 36453989, PMCID: PMC9757052 [ AbstractWatts JA, Grunseich C, Rodriguez Y, Liu Y, Li D, Burdick JT, Bruzel A, Crouch RJ, Mahley RW, Wilson SH, Cheung VG. A Common Transcriptional Mechanism Involving R-loop and RNA Abasic Site Regulates an Enhancer RNA of APOE. Nucleic Acids Research. December 2022. PMID: 36453989, PMCID: PMC9757052 ]
- Snyder R, Delker D, Burdick JT, Cheung VG, Watts JA. Guanine Quadruplexes Mediate Mitochondrial RNA Polymerase Pausing. BIORXIV/2023/562821. PMID: 37905021, PMCID: PMC10614896 [ AbstractSnyder R, Delker D, Burdick JT, Cheung VG, Watts JA. Guanine Quadruplexes Mediate Mitochondrial RNA Polymerase Pausing. BIORXIV/2023/562821. PMID: 37905021, PMCID: PMC10614896 ]