Selected Publications

DNA Repair & Nucleic Acid Enzymology Group

  1. Wilson, S.H. and Kuff, E.L. A novel DNA polymerase activity found in association with intracisternal A-type particles. Proc. Natl. Acad. Sci. USA, 69:1531-1536, 1972. [ AbstractWilson, S.H. and Kuff, E.L. A novel DNA polymerase activity found in association with intracisternal A-type particles. Proc. Natl. Acad. Sci. USA, 69:1531-1536, 1972. ]
  2. Matsukage, A., Bohn, E.W., and Wilson, S.H. Multiple forms of DNA polymerase in mouse myeloma. Proc. Natl. Acad. Sci. USA, 71:578-582, 1974. [ AbstractMatsukage, A., Bohn, E.W., and Wilson, S.H. Multiple forms of DNA polymerase in mouse myeloma. Proc. Natl. Acad. Sci. USA, 71:578-582, 1974. ]
  3. Tanabe, K., Bohn, E.W., and Wilson, S.H. Steady-state kinetics of mouse DNA polymerase β. Biochemistry, 18:3401-3407, 1979. [ AbstractTanabe, K., Bohn, E.W., and Wilson, S.H. Steady-state kinetics of mouse DNA polymerase β. Biochemistry, 18:3401-3407, 1979. ]
  4. Zmudzka, B.Z., SenGupta, D., Matsukage, A., Cobianchi, F., Kumar, P., and Wilson, S.H. Structure of rat DNA polymerase β revealed by partial amino acid sequencing and cDNA cloning. Proc. Natl. Acad. Sci. USA, 83:5106-5110, 1986. [ AbstractZmudzka, B.Z., SenGupta, D., Matsukage, A., Cobianchi, F., Kumar, P., and Wilson, S.H. Structure of rat DNA polymerase β revealed by partial amino acid sequencing and cDNA cloning. Proc. Natl. Acad. Sci. USA, 83:5106-5110, 1986. ]
  5. Widen, S., Kedar, P., and Wilson, S.H. Human β-polymerase gene: Structure of the 5' flanking region and active promoter. J. Biol. Chem., 263:16992-16998, 1988. [ AbstractWiden, S., Kedar, P., and Wilson, S.H. Human β-polymerase gene: Structure of the 5' flanking region and active promoter. J. Biol. Chem., 263:16992-16998, 1988. ]
  6. Beard, W.A. and Wilson, S.H. Kinetic analysis of template primer interactions with recombinant forms of HIV-1 reverse transcriptase. Biochemistry, 32:9745-9753, 1993. [ AbstractBeard, W.A. and Wilson, S.H. Kinetic analysis of template primer interactions with recombinant forms of HIV-1 reverse transcriptase. Biochemistry, 32:9745-9753, 1993. ]
  7. Narayan, S., Widen, S.G., Beard, W.A., and Wilson, S.H. RNA polymerse II transcription: Rate of promoter clearance is enhanced by a purified activating transcription factor/cAMP response element-binding protein. J. Biol. Chem., 269, 12755-12763, 1994. [ AbstractNarayan, S., Widen, S.G., Beard, W.A., and Wilson, S.H. RNA polymerse II transcription: Rate of promoter clearance is enhanced by a purified activating transcription factor/cAMP response element-binding protein. J. Biol. Chem., 269, 12755-12763, 1994. ]
  8. Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., and Kraut, J. Crystal structure of rat DNA polymerase β: Evidence for a common polymerase mechanism. Science, 264:1930-1935, 1994. [ AbstractSawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., and Kraut, J. Crystal structure of rat DNA polymerase β: Evidence for a common polymerase mechanism. Science, 264:1930-1935, 1994. ]
  9. Pelletier, H., Sawaya, M.R., Kumar, A., Wilson, S.H., and Kraut, J. Structures of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP. Science, 264:1891-1903, 1994. [ AbstractPelletier, H., Sawaya, M.R., Kumar, A., Wilson, S.H., and Kraut, J. Structures of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP. Science, 264:1891-1903, 1994. ]
  10. Singhal, R.K., Prasad, R., and Wilson, S.H. DNA polymerase β conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. J. Biol. Chem., 270:949-957, 1995. [ AbstractSinghal, R.K., Prasad, R., and Wilson, S.H. DNA polymerase β conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. J. Biol. Chem., 270:949-957, 1995. ]
  11. Kunkel, T.A. and Wilson, S.H. DNA Repair. Push and pull of base flipping. Nature, 384:25-26, 1996. [ AbstractKunkel, T.A. and Wilson, S.H. DNA Repair. Push and pull of base flipping. Nature, 384:25-26, 1996. ]
  12. Sobol, R.W., Horton, J.K., Kühn, R., Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K., and Wilson, S.H. Requirement of mammalian DNA polymerase-β in base-excision repair. Nature, 379:183-186, 1996. [ AbstractSobol, R.W., Horton, J.K., Kühn, R., Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K., and Wilson, S.H. Requirement of mammalian DNA polymerase-β in base-excision repair. Nature, 379:183-186, 1996. ]
  13. He, F., Narayan, S., and Wilson, S.H. Purification and characterization of a DNA polymerase β promoter initiator element-binding transcription factor from bovine testis. Biochemistry, 35:1775-1782, 1996. [ AbstractHe, F., Narayan, S., and Wilson, S.H. Purification and characterization of a DNA polymerase β promoter initiator element-binding transcription factor from bovine testis. Biochemistry, 35:1775-1782, 1996. ]
  14. Srivastava, D.K., Evans, R.K., Kumar, A., Beard, W.A., and Wilson, S.H. dNTP binding site in rat DNA polymerase β revealed by controlled proteolysis and azido photoprobe cross-linking. Biochemistry, 35:3728-3734, 1996. [ AbstractSrivastava, D.K., Evans, R.K., Kumar, A., Beard, W.A., and Wilson, S.H. dNTP binding site in rat DNA polymerase β revealed by controlled proteolysis and azido photoprobe cross-linking. Biochemistry, 35:3728-3734, 1996. ]
  15. Beard, W.A., Osheroff, W.P., Prasad, R., Jaju, M., Sawaya, M.R., Wood, T.G., Kraut, J., Kunkel, T.A., and Wilson, S.H. Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase β. J. Biol. Chem., 271:12141-12144, 1996. [ AbstractBeard, W.A., Osheroff, W.P., Prasad, R., Jaju, M., Sawaya, M.R., Wood, T.G., Kraut, J., Kunkel, T.A., and Wilson, S.H. Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase β. J. Biol. Chem., 271:12141-12144, 1996. ]
  16. Beard, W.A., Minnick, D., Wade, C., Prasad, R., Won, R.L., Kumar, A., Kunkel, T.A., and Wilson, S.H. Role of the "Helix Clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis. J. Biol. Chem., 271: 12213-12220, 1996. [ AbstractBeard, W.A., Minnick, D., Wade, C., Prasad, R., Won, R.L., Kumar, A., Kunkel, T.A., and Wilson, S.H. Role of the "Helix Clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis. J. Biol. Chem., 271: 12213-12220, 1996. ]
  17. Liu, D., Prasad, R., Wilson, S.H., DeRose, E.F., and Mullen, G.P. Three-dimensional solution structure of the N-terminal domain of DNA polymerase β and mapping of the ssDNA interaction interface. Biochemistry, 35:6188-6200, 1996. [ AbstractLiu, D., Prasad, R., Wilson, S.H., DeRose, E.F., and Mullen, G.P. Three-dimensional solution structure of the N-terminal domain of DNA polymerase β and mapping of the ssDNA interaction interface. Biochemistry, 35:6188-6200, 1996. ]
  18. Chyan, Y.-J., Strauss, P.R., Wood, T.G., and Wilson, S.H. Identification of novel mRNA isoforms for human DNA polymerase β. DNA and Cell Biology, 15:653-659, 1996. [ AbstractChyan, Y.-J., Strauss, P.R., Wood, T.G., and Wilson, S.H. Identification of novel mRNA isoforms for human DNA polymerase β. DNA and Cell Biology, 15:653-659, 1996. ]
  19. Oda, N., Saxena, J.K., Jenkins, T.M., Prasad, R., Wilson, S.H., and Ackerman, E.J. DNA polymerases β and β are required for DNA repair in an efficient nuclear extract from Xenopus oocytes. J. Biol. Chem., 271:13816-13820, 1996. [ AbstractOda, N., Saxena, J.K., Jenkins, T.M., Prasad, R., Wilson, S.H., and Ackerman, E.J. DNA polymerases β and β are required for DNA repair in an efficient nuclear extract from Xenopus oocytes. J. Biol. Chem., 271:13816-13820, 1996. ]
  20. Prasad, R., Singhal, R.K., Srivastava, D.K., Tomkinson, A.E., and Wilson, S.H. Specific interaction of DNA polymerase β and DNA ligase I in a multiprotein base excision repair complex from bovine testis. J. Biol. Chem., 271:16000-16007, 1996. [ AbstractPrasad, R., Singhal, R.K., Srivastava, D.K., Tomkinson, A.E., and Wilson, S.H. Specific interaction of DNA polymerase β and DNA ligase I in a multiprotein base excision repair complex from bovine testis. J. Biol. Chem., 271:16000-16007, 1996. ]
  21. Piersen, C.E., Prasad, R., Wilson, S.H., and Lloyd, R.S. Evidence for an imino intermediate in the DNA polymerase β deoxyribose phosphate excision reaction. J. Biol. Chem., 271:17811-17815, 1996. [ AbstractPiersen, C.E., Prasad, R., Wilson, S.H., and Lloyd, R.S. Evidence for an imino intermediate in the DNA polymerase β deoxyribose phosphate excision reaction. J. Biol. Chem., 271:17811-17815, 1996. ]
  22. Narayan, S., He, F., and Wilson, S.H. Activation of the human DNA polymerase β promoter by a DNA-alkylating agent through induced phosphorylation of CREB-1. J. Biol. Chem., 271:18508-18513, 1996. [ AbstractNarayan, S., He, F., and Wilson, S.H. Activation of the human DNA polymerase β promoter by a DNA-alkylating agent through induced phosphorylation of CREB-1. J. Biol. Chem., 271:18508-18513, 1996. ]
  23. Lavrik, O.I., Prasad, R., Beard, W.A., Safronov, I.V., Dobrikov, M.I., Srivastava, D.K., Shishkin, G.V., Wood, T.G., and Wilson, S.H. dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase β as revealed by affinity labeling with a photoreactive dNTP analog. J. Biol. Chem., 271:21891-21897, 1996. [ AbstractLavrik, O.I., Prasad, R., Beard, W.A., Safronov, I.V., Dobrikov, M.I., Srivastava, D.K., Shishkin, G.V., Wood, T.G., and Wilson, S.H. dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase β as revealed by affinity labeling with a photoreactive dNTP analog. J. Biol. Chem., 271:21891-21897, 1996. ]
  24. Pelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. Crystal structures of human DNA polymerase β complexed with DNA: Implications for catalytic mechanism, processivity, and fidelity. Biochemistry, 35:12742-12761, 1996. [ AbstractPelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. Crystal structures of human DNA polymerase β complexed with DNA: Implications for catalytic mechanism, processivity, and fidelity. Biochemistry, 35:12742-12761, 1996. ]
  25. Pelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase β. Biochemistry, 35:12762-12777, 1996. [ AbstractPelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase β. Biochemistry, 35:12762-12777, 1996. ]
  26. Reha-Krantz, L.J., Nonay, R.L., Day III, R.S., and Wilson, S.H. Replication of O6-Methylguanine-containing DNA by repair and replicative DNA polymerases. J. Biol. Chem., 271:20088-20095, 1996. [ AbstractReha-Krantz, L.J., Nonay, R.L., Day III, R.S., and Wilson, S.H. Replication of O6-Methylguanine-containing DNA by repair and replicative DNA polymerases. J. Biol. Chem., 271:20088-20095, 1996. ]
  27. Mullen, G.P. and Wilson, S.H. Repair activity in DNA polymerases: a structurally conserved helix-hairpin-helix motif in base excision repair enzymes and in DNA polymerase β. IN: Hickson, I.D. (ed), Base Excision Repair of DNA Damage. Landes Bioscience, 1997, pp. 121-135.
  28. Strauss, P.R., Beard, W.A., Patterson, T.A., and Wilson, S.H. Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane Mechanism. J. Biol. Chem., 272:1302-1307, 1997. [ AbstractStrauss, P.R., Beard, W.A., Patterson, T.A., and Wilson, S.H. Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane Mechanism. J. Biol. Chem., 272:1302-1307, 1997. ]
  29. Efrati, E., Tocco, G., Eritja, R., Wilson, S.H., and Goodman, M.F. Abasic translesion synthesis by DNA polymerase β violates the "A-Rule": Novel types of nucleotide incorporation by human DNA polymerase β at an abasic lesion in different sequence contexts. J. Biol. Chem., 272:2559-2569, 1997. [ AbstractEfrati, E., Tocco, G., Eritja, R., Wilson, S.H., and Goodman, M.F. Abasic translesion synthesis by DNA polymerase β violates the "A-Rule": Novel types of nucleotide incorporation by human DNA polymerase β at an abasic lesion in different sequence contexts. J. Biol. Chem., 272:2559-2569, 1997. ]
  30. Forgacs, E., Latham, G., Beard, W.A., Prasad, R., Bebenek, K., Kunkel, T.A., Wilson, S.H., and Lloyd, R.S. Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-Guanine adducts. J. Biol. Chem., 272:8525-8530, 1997. [ AbstractForgacs, E., Latham, G., Beard, W.A., Prasad, R., Bebenek, K., Kunkel, T.A., Wilson, S.H., and Lloyd, R.S. Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-Guanine adducts. J. Biol. Chem., 272:8525-8530, 1997. ]
  31. Kim, S., Merrill, B.M., Rajpurohit, R., Kumar, A., Stone, K.L., Papov, V.V., Schneidersm J.M., Szer, W., Wilson, S.H., Paik, W.K., and Williams, K.R. Identification of NG-Methylarginine residues in human heterogeneous RNP protein A1: Phe/Gly-Gly-Gly-Arg-Gly-Gly-Gly/Phe is a preferred recognition motif. Biochemistry, 36:5185-5192, 1997. [ AbstractKim, S., Merrill, B.M., Rajpurohit, R., Kumar, A., Stone, K.L., Papov, V.V., Schneidersm J.M., Szer, W., Wilson, S.H., Paik, W.K., and Williams, K.R. Identification of NG-Methylarginine residues in human heterogeneous RNP protein A1: Phe/Gly-Gly-Gly-Arg-Gly-Gly-Gly/Phe is a preferred recognition motif. Biochemistry, 36:5185-5192, 1997. ]
  32. Mullen, G.P. and Wilson, S.H. DNA polymerase β in abasic site repair: a structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes. Biochemistry, 36:4713-4717, 1997. [ AbstractMullen, G.P. and Wilson, S.H. DNA polymerase β in abasic site repair: a structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes. Biochemistry, 36:4713-4717, 1997. ]
  33. Bebenek, K., Beard, W.A., Darden, T.A., Li, L., Prasad, R., Luxon, B.A., Gorenstein, D.G., Wilson, S.H., and Kunkel, T.A. A minor groove binding track in reverse transcriptase. Nat. Struct. Biol., 4:194-197, 1997. [ AbstractBebenek, K., Beard, W.A., Darden, T.A., Li, L., Prasad, R., Luxon, B.A., Gorenstein, D.G., Wilson, S.H., and Kunkel, T.A. A minor groove binding track in reverse transcriptase. Nat. Struct. Biol., 4:194-197, 1997. ]
  34. Butler, A.P., Johnson, D.G., Kumar, A.P., Narayan, S., Wilson, S.H., and MacLeod, M.C. Disruption of transcription in vitro and gene expression in vivo by DNA adducts derived from a benzo[a]pyrene diol epoxide located in heterologous sequences. Carcinogenesis, 18:239-244, 1997. [ AbstractButler, A.P., Johnson, D.G., Kumar, A.P., Narayan, S., Wilson, S.H., and MacLeod, M.C. Disruption of transcription in vitro and gene expression in vivo by DNA adducts derived from a benzo[a]pyrene diol epoxide located in heterologous sequences. Carcinogenesis, 18:239-244, 1997. ]
  35. Mullen, G.P., Antuch, W., Maciejewski, M.W., Prasad, R., and Wilson, S.H. Insights into the mechanism of the β-elimination catalyzed by the N-terminal domain of DNA polymerase β. Tetrahedron, 53:12057-12066, 1997.
  36. Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., and Pelletier, H. Crystal structures of human DNA polymerase β complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Biochemistry, 36:11205-11215, 1997. [ AbstractSawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., and Pelletier, H. Crystal structures of human DNA polymerase β complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Biochemistry, 36:11205-11215, 1997. ]
  37. Yang, X-P., He, F., Rawson, T.Y., and Wilson, S.H. Human DNA polymerase β promoter: Phorbol ester activation is mediated through the cAMP response element and cAMP-response-element-binding protein. J. Biomed. Sci., 4:279-288, 1997. [ AbstractYang, X-P., He, F., Rawson, T.Y., and Wilson, S.H. Human DNA polymerase β promoter: Phorbol ester activation is mediated through the cAMP response element and cAMP-response-element-binding protein. J. Biomed. Sci., 4:279-288, 1997. ]
  38. Wilson, S.H., Sobol, R.W., Beard, W.A., Horton, J.K., Prasad, R., and Vande Berg, B.J. DNA polymerase-β and mammalian base excision repair. IN: Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory Press, 2000, Vol. 65, pp. 143-155. [ AbstractWilson, S.H., Sobol, R.W., Beard, W.A., Horton, J.K., Prasad, R., and Vande Berg, B.J. DNA polymerase-β and mammalian base excision repair. IN: Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory Press, 2000, Vol. 65, pp. 143-155. ]
  39. Beard, W.A., Shock, D.D., Yang, X.-P., DeLauder, S.F., and Wilson, S.H. Loss of DNA polymerase β stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. J. Biol. Chem., 277:8235-8242, 2002. [ AbstractBeard, W.A., Shock, D.D., Yang, X.-P., DeLauder, S.F., and Wilson, S.H. Loss of DNA polymerase β stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. J. Biol. Chem., 277:8235-8242, 2002. ]
  40. Beard, W.A., Shock, D.D., Vande Berg, B.J., and Wilson, S.H. Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. J. Biol. Chem., 277:47393-47398, 2002. [ AbstractBeard, W.A., Shock, D.D., Vande Berg, B.J., and Wilson, S.H. Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. J. Biol. Chem., 277:47393-47398, 2002. ]
  41. Beard, W.A., and Wilson, S.H. Structural insights into the origins of DNA polymerase fidelity. Structure (Camb.), 11:489-496, 2003. [ AbstractBeard, W.A., and Wilson, S.H. Structural insights into the origins of DNA polymerase fidelity. Structure (Camb.), 11:489-496, 2003. ]
  42. Horton, J.K., Stefanick, D.F., Naron, J.M., Kedar, P.S., and Wilson, S.H. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest following DNA methylating agent exposure. J. Biol. Chem., 280:15773-15785, 2005. [ AbstractHorton, J.K., Stefanick, D.F., Naron, J.M., Kedar, P.S., and Wilson, S.H. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest following DNA methylating agent exposure. J. Biol. Chem., 280:15773-15785, 2005. ]
  43. Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., and Wilson, S.H. Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure (Camb.), 13:1225-1233, 2005. [ AbstractBatra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., and Wilson, S.H. Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure (Camb.), 13:1225-1233, 2005. ]
  44. Prasad, R., Batra, V.K., Yang, X.-P., Krahn, J.M., Pedersen, L.C., Beard, W.A., and Wilson, S.H. Structural insight into the DNA polymerase β deoxyribose phosphate lyase mechanism. DNA Repair (Amst.), 4:1347-1357, 2005. [ AbstractPrasad, R., Batra, V.K., Yang, X.-P., Krahn, J.M., Pedersen, L.C., Beard, W.A., and Wilson, S.H. Structural insight into the DNA polymerase β deoxyribose phosphate lyase mechanism. DNA Repair (Amst.), 4:1347-1357, 2005. ]
  45. Kirby, T.W., DeRose, E.F., Beard, W.A., Wilson, S.H., and London, R.E. A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase β ternary complex. Biochemistry, 44:15230-15237, 2005. [ AbstractKirby, T.W., DeRose, E.F., Beard, W.A., Wilson, S.H., and London, R.E. A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase β ternary complex. Biochemistry, 44:15230-15237, 2005. ]
  46. Beard, W.A. and Wilson, S.H. Structure and mechanism of DNA polymerase β. Chemical Reviews, "DNA Damage and Repair," 106:361-382, 2006. [ AbstractBeard, W.A. and Wilson, S.H. Structure and mechanism of DNA polymerase β. Chemical Reviews, "DNA Damage and Repair," 106:361-382, 2006. ]
  47. Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., and Wilson, S.H. Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (Camb.), 14:757-766, 2006. [ AbstractBatra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., and Wilson, S.H. Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (Camb.), 14:757-766, 2006. ]
  48. Yoshimura, M., Kohzaki, M., Nakamura, J., Asagoshi, K., Sonoda, E., Hou, E., Prasad, R., Wilson, S.H., Tano, K., Yasui, A., Lan, L., Seki, M., Wood, R.D., Arakawa, H. Buerstedde, J.-M., Hochegger, H., Okada, T., Hiraoka, M., and Takeda, S. Vertebrate PolQ and Polβ cooperate in base excision repair of oxidative DNA damage. Mol. Cell, 24:115-125, 2006. [ AbstractYoshimura, M., Kohzaki, M., Nakamura, J., Asagoshi, K., Sonoda, E., Hou, E., Prasad, R., Wilson, S.H., Tano, K., Yasui, A., Lan, L., Seki, M., Wood, R.D., Arakawa, H. Buerstedde, J.-M., Hochegger, H., Okada, T., Hiraoka, M., and Takeda, S. Vertebrate PolQ and Polβ cooperate in base excision repair of oxidative DNA damage. Mol. Cell, 24:115-125, 2006. ]
  49. Lin, P., Pedersen, L.C., Batra, V.K., Beard, W.A., Wilson, S.H., and Pedersen, L.G. Energy analysis of chemistry for correct nucleotide insertion by DNA polymerase β. Proc. Natl. Acad. Sci. USA, 103:13294-13299, 2006. [ AbstractLin, P., Pedersen, L.C., Batra, V.K., Beard, W.A., Wilson, S.H., and Pedersen, L.G. Energy analysis of chemistry for correct nucleotide insertion by DNA polymerase β. Proc. Natl. Acad. Sci. USA, 103:13294-13299, 2006. ]
  50. Batra, V.K., Shock, D.D., Prasad, R., Beard, W.A., Hou, E.W., Pedersen, L.C., Sayer, J.M., Yagi, H., Kumar, S., Jerina, D.M., and Wilson, S.H. Structure of DNA polymerase β with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proc. Natl. Acad. Sci. USA, 103:17231-17236, 2006. [ AbstractBatra, V.K., Shock, D.D., Prasad, R., Beard, W.A., Hou, E.W., Pedersen, L.C., Sayer, J.M., Yagi, H., Kumar, S., Jerina, D.M., and Wilson, S.H. Structure of DNA polymerase β with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proc. Natl. Acad. Sci. USA, 103:17231-17236, 2006. ]
  51. Radhakrishnan, R., Arora, K., Wang, Y., Beard, W.A., Wilson, S.H., and Schlick, T. Regulation of DNA repair fidelity by molecular checkpoints: "Gates" in DNA polymerase β’s substrate selection. Biochemistry, 45:15142-15156, 2006. [ AbstractRadhakrishnan, R., Arora, K., Wang, Y., Beard, W.A., Wilson, S.H., and Schlick, T. Regulation of DNA repair fidelity by molecular checkpoints: "Gates" in DNA polymerase β’s substrate selection. Biochemistry, 45:15142-15156, 2006. ]
  52. Das A., Wiederhold L., Leppard J.B., Kedar P., Prasad R., Wang H., Boldogh I., Karimi-Busheri F., Weinfeld M., Tomkinson A.E., Wilson S.H., Mitra S., Hazra T. NEIL2-Initiated, APE-independent repair of oxidated bases in DNA: Evidence for a repair complex in human cell. DNA repair 5(12):1439-1448, 2006. [ AbstractDas A., Wiederhold L., Leppard J.B., Kedar P., Prasad R., Wang H., Boldogh I., Karimi-Busheri F., Weinfeld M., Tomkinson A.E., Wilson S.H., Mitra S., Hazra T. NEIL2-Initiated, APE-independent repair of oxidated bases in DNA: Evidence for a repair complex in human cell. DNA repair 5(12):1439-1448, 2006. ]
  53. Horton, J.K., Stefanick, D.F., Kedar, P.S., and Wilson, S.H. ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity. DNA Repair (Amst.), 6(6):742-50, 2007. [ AbstractHorton, J.K., Stefanick, D.F., Kedar, P.S., and Wilson, S.H. ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity. DNA Repair (Amst.), 6(6):742-50, 2007. ]
  54. Wang Y., Reddy S., Beard W.A., Wilson S.H., Schlick T. Differing conformational pathways before and after chemistry for insertion of dATP vs. dCTP opposite 8-oxoG in DNA polymerase beta. Biophysical journal, 9: 3063-3070, 2007. [ AbstractWang Y., Reddy S., Beard W.A., Wilson S.H., Schlick T. Differing conformational pathways before and after chemistry for insertion of dATP vs. dCTP opposite 8-oxoG in DNA polymerase beta. Biophysical journal, 9: 3063-3070, 2007. ]
  55. Das S., Chattopadhyay R., Bhakat K.K., Boldogh I., Kohno K., Prasad R., Wilson S.H., Hazra T.K. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. The Journal of biological chemistry, 282(39):28474-28484, 2007. [ AbstractDas S., Chattopadhyay R., Bhakat K.K., Boldogh I., Kohno K., Prasad R., Wilson S.H., Hazra T.K. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. The Journal of biological chemistry, 282(39):28474-28484, 2007. ]
  56. Moon, A.F., Garcia-Diaz, M., Batra, V.K., Beard, W.A., Bebenek, K., Kunkel, T.A., Wilson, S.H., Pedersen, L.C. The X family portrait: structural insights into biological functions of X family polymerases. DNA repair, 6(12):1709-1725, 2007. [ AbstractMoon, A.F., Garcia-Diaz, M., Batra, V.K., Beard, W.A., Bebenek, K., Kunkel, T.A., Wilson, S.H., Pedersen, L.C. The X family portrait: structural insights into biological functions of X family polymerases. DNA repair, 6(12):1709-1725, 2007. ]
  57. Kovtun, I.V., Liu, Y., Bjoras, M., Klungland, A., Wilson, S.H., McMurray, C.T. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature, 447(7143):447-452, 2007. [ AbstractKovtun, I.V., Liu, Y., Bjoras, M., Klungland, A., Wilson, S.H., McMurray, C.T. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature, 447(7143):447-452, 2007. ]
  58. Liu, Y., Prasad, R., Beard, W.A., Kedar, P.S., Hou, E.W., Shock, D.D., Wilson, S.H. Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase β. The Journal of biological chemistry, 282(18):13532-13541, 2007. [ AbstractLiu, Y., Prasad, R., Beard, W.A., Kedar, P.S., Hou, E.W., Shock, D.D., Wilson, S.H. Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase β. The Journal of biological chemistry, 282(18):13532-13541, 2007. ]
  59. Nakanishi, S., Prasad R., Wilson S.H., Smerdon M. Different structural states in oligonucleosomes are required for early versus late steps of base excision repair. Nucleic Acids Research, 35(13):4313-4321, 2007. [ AbstractNakanishi, S., Prasad R., Wilson S.H., Smerdon M. Different structural states in oligonucleosomes are required for early versus late steps of base excision repair. Nucleic Acids Research, 35(13):4313-4321, 2007. ]
  60. Palma, N., Cinelli S., Sapora O., Wilson S.H., Dogliotti E. Ochratoxin A-induced mutagenesis in mammalian cells is consistent with production of oxidative stress. Chemical research in toxicology, 20(7):1031-1037, 2007. [ AbstractPalma, N., Cinelli S., Sapora O., Wilson S.H., Dogliotti E. Ochratoxin A-induced mutagenesis in mammalian cells is consistent with production of oxidative stress. Chemical research in toxicology, 20(7):1031-1037, 2007. ]
  61. Tano, K., Nakamura J., Asagoshi K., Arakawa H., Sonoda E., Braithwaite E.K., Prasad R., Buerstedde J.-M., Takeda S., Watanabe M., Wilson S.H. Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. DNA repair, 6(6):869-875, 2007. [ AbstractTano, K., Nakamura J., Asagoshi K., Arakawa H., Sonoda E., Braithwaite E.K., Prasad R., Buerstedde J.-M., Takeda S., Watanabe M., Wilson S.H. Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. DNA repair, 6(6):869-875, 2007. ]
  62. Oelschlaeger, P., Klahn M., Beard W.A., Wilson S.H., Warshel A. Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: Improved accuracy in studies of structural features and mutational effects. Journal of molecular biology, 366(2):687-701, 2007. [ AbstractOelschlaeger, P., Klahn M., Beard W.A., Wilson S.H., Warshel A. Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: Improved accuracy in studies of structural features and mutational effects. Journal of molecular biology, 366(2):687-701, 2007. ]
  63. Hou, E.W., Prasad R., Asagoshi K., Masaoka A., Wilson S.H. Comparative assessment of plasmid and oligonucleotide DNA substrates in measurement of in vitro base excision repair activity. Nucleic acids research, 35(17):e112, 2007. [ AbstractHou, E.W., Prasad R., Asagoshi K., Masaoka A., Wilson S.H. Comparative assessment of plasmid and oligonucleotide DNA substrates in measurement of in vitro base excision repair activity. Nucleic acids research, 35(17):e112, 2007. ]
  64. McKenna, C.E., Kashemirov B.A., Upton T.G., Batra V.K., Goodman M.F., Pedersen L.C., Beard W.A., Wilson S.H. (R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Journal of the American Chemical Society, 129(50):15412-15413, 2007. [ AbstractMcKenna, C.E., Kashemirov B.A., Upton T.G., Batra V.K., Goodman M.F., Pedersen L.C., Beard W.A., Wilson S.H. (R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Journal of the American Chemical Society, 129(50):15412-15413, 2007. ]
  65. Prasad, R., Liu Y., Deterding L.J., Poltoratsky V.P., Kedar P.S., Horton J.K., Kanno S.I., Asagoshi K., Hou E.W., Khodyreva S.N., Lavrik O.I., Tomer K.B., Yasui A., Wilson S.H. HMGB1 is a co-factor in mammalian base excision repair. Molecular cell, 27(5):829-841, 2007. [ AbstractPrasad, R., Liu Y., Deterding L.J., Poltoratsky V.P., Kedar P.S., Horton J.K., Kanno S.I., Asagoshi K., Hou E.W., Khodyreva S.N., Lavrik O.I., Tomer K.B., Yasui A., Wilson S.H. HMGB1 is a co-factor in mammalian base excision repair. Molecular cell, 27(5):829-841, 2007. ]
  66. Wilson SH. DNA Damage Recognition, W. Siede, W. Kow, P. Doetsch (Eds.), Taylor & Francis Group. New York (2006) ISBN: 10-0-8247-5961-3; 13:978-0-8247-5961-2. DNA Repair 2007.
  67. Horton, J.K., Watson M., Stefanick D.F., Shaughnessy D.T., Taylor J.A., Wilson S.H. XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell research, 18(1):48-63, 2008. [ AbstractHorton, J.K., Watson M., Stefanick D.F., Shaughnessy D.T., Taylor J.A., Wilson S.H. XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell research, 18(1):48-63, 2008. ]
  68. Xiang, Y., Goodman M.F., Beard W.A., Wilson S.H., Warshel A. Exploring the role of large conformational changes in the fidelity of DNA Polymerase beta. Proteins, 70(1):231-247, 2008. [ AbstractXiang, Y., Goodman M.F., Beard W.A., Wilson S.H., Warshel A. Exploring the role of large conformational changes in the fidelity of DNA Polymerase beta. Proteins, 70(1):231-247, 2008. ]
  69. Batra, V.K., Beard W.A., Shock D.D., Pedersen L.C., Wilson S.H. Structures of DNA polymerase beta with active site mismatches suggest a transient abasic site intermediate during misincorporation. Molecular cell, 30(3):315-324, 2008. [ AbstractBatra, V.K., Beard W.A., Shock D.D., Pedersen L.C., Wilson S.H. Structures of DNA polymerase beta with active site mismatches suggest a transient abasic site intermediate during misincorporation. Molecular cell, 30(3):315-324, 2008. ]
  70. Kronenberg, G., Harms C., Sobol R.W., Cardozo-Pelaez F., Linhart H., Winter B., Balkaya M., Gertz K., Gay S.B., Cox D., Eckart S., Ahmadi M., Juckel G., Kempermann G., Hellweg R., Sorh R., Hortnagl H., Wilson S.H., Jaenisch R., Endres M. Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. The Journal of neuroscience: the official journal of the Society for Neuroscience. 28(28):7219-7230, 2008. [ AbstractKronenberg, G., Harms C., Sobol R.W., Cardozo-Pelaez F., Linhart H., Winter B., Balkaya M., Gertz K., Gay S.B., Cox D., Eckart S., Ahmadi M., Juckel G., Kempermann G., Hellweg R., Sorh R., Hortnagl H., Wilson S.H., Jaenisch R., Endres M. Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. The Journal of neuroscience: the official journal of the Society for Neuroscience. 28(28):7219-7230, 2008. ]
  71. Kedar, P.S., Stefanick D.F., Horton J.K., Wilson S.H. Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition. DNA repair, 7(11):1787-1798, 2008. [ AbstractKedar, P.S., Stefanick D.F., Horton J.K., Wilson S.H. Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition. DNA repair, 7(11):1787-1798, 2008. ]
  72. Allen, D., Herbert D.C., McMahan C.A., Rotrekl V., Sobol R.W., Wilson S.H., Walter C.A. Mutagenesis is elevated in male germs cells obtained from DNA polymerase-beta heterozygous mice. Biology of reproduction, 79(5):824-831, 2008. [ AbstractAllen, D., Herbert D.C., McMahan C.A., Rotrekl V., Sobol R.W., Wilson S.H., Walter C.A. Mutagenesis is elevated in male germs cells obtained from DNA polymerase-beta heterozygous mice. Biology of reproduction, 79(5):824-831, 2008. ]
  73. Poltoratsky, V.P., Horton, J.K., Prasad, R., Beard, W.A., Woodgate, R., Wilson, S.H. Negligible impact of pol iota expression on the alkylation sensitivity of pol beta-deficient mouse fibroblast cells. DNA repair, 7(6):830-833, 2008. [ AbstractPoltoratsky, V.P., Horton, J.K., Prasad, R., Beard, W.A., Woodgate, R., Wilson, S.H. Negligible impact of pol iota expression on the alkylation sensitivity of pol beta-deficient mouse fibroblast cells. DNA repair, 7(6):830-833, 2008. ]
  74. Liang, F., Jain, N., Hutchens, T., Shock, D.D., Beard, W.A., Wilson, S.H., Chiarelli, N.P., Cho, B.P. Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT. Journal of medicinal chemistry, 51(20):6460-6470, 2008. [ AbstractLiang, F., Jain, N., Hutchens, T., Shock, D.D., Beard, W.A., Wilson, S.H., Chiarelli, N.P., Cho, B.P. Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT. Journal of medicinal chemistry, 51(20):6460-6470, 2008. ]
  75. Carrozza, M., Stefanick, D.F., Horton, J.K., Kedar, P.S., Wilson, S.H. PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. DNA Repair, 8(11):1264-1272, 2009. [ AbstractCarrozza, M., Stefanick, D.F., Horton, J.K., Kedar, P.S., Wilson, S.H. PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. DNA Repair, 8(11):1264-1272, 2009. ]
  76. Liu, Y., Prasad R., Beard W.A., Hou E.W., Horton J.K., McMurray C.T., Wilson S.H. Coordination between Pol ² and FEN1 can modulate CAG repeat expansion. The Journal of biological chemistry, 284(41):28352-28366, 2009. [ AbstractLiu, Y., Prasad R., Beard W.A., Hou E.W., Horton J.K., McMurray C.T., Wilson S.H. Coordination between Pol ² and FEN1 can modulate CAG repeat expansion. The Journal of biological chemistry, 284(41):28352-28366, 2009. ]
  77. Dorjsuren, D., Wilson III D.M., Beard W.A., McDonald J.P., Austin C.P., Woodgate R., Wilson S.H., Simeonov A. A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic acids research, 37(19):e128, 2009. [ AbstractDorjsuren, D., Wilson III D.M., Beard W.A., McDonald J.P., Austin C.P., Woodgate R., Wilson S.H., Simeonov A. A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic acids research, 37(19):e128, 2009. ]
  78. Yoshizawa, K., Jelezcova E., Brown A.R., Foley J.F., Nyska A., Cui X., Hofseth L., Maronpot R., Wilson S.H., Sepulveda A.R., Sobol R.W. Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. PloS one, 4(8):e6493, 2009. [ AbstractYoshizawa, K., Jelezcova E., Brown A.R., Foley J.F., Nyska A., Cui X., Hofseth L., Maronpot R., Wilson S.H., Sepulveda A.R., Sobol R.W. Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. PloS one, 4(8):e6493, 2009. ]
  79. Simonelli, V., D'Errico M., Palli D., Prasad R., Wilson S.H., Dogliotti E. Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA. Mutation research, 670(1-2):79-87, 2009. [ AbstractSimonelli, V., D'Errico M., Palli D., Prasad R., Wilson S.H., Dogliotti E. Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA. Mutation research, 670(1-2):79-87, 2009. ]
  80. Prasad, R., Longley, M.J., Sharief, F.S., Hou, E.W., Copeland, W.C., and Wilson S.H. Human DNA polymerase theta¸ possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Nucleic acids research, 37(6):1868-1877, 2009. [ AbstractPrasad, R., Longley, M.J., Sharief, F.S., Hou, E.W., Copeland, W.C., and Wilson S.H. Human DNA polymerase theta¸ possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Nucleic acids research, 37(6):1868-1877, 2009. ]
  81. Masaoka, A., Horton, J.K., Beard, W.A., and Wilson, S.H. DNA polymerase beta and PARP activities in base excision repair in living cells. DNA repair, 8(11):1290-1299, 2009. [ AbstractMasaoka, A., Horton, J.K., Beard, W.A., and Wilson, S.H. DNA polymerase beta and PARP activities in base excision repair in living cells. DNA repair, 8(11):1290-1299, 2009. ]
  82. Beard, W.A., Shock, D.D., Batra, V.K., Pedersen, L.C., and Wilson, S.H. DNA Polymerase Beta Substrate Specificity: Side chain modulation of the 'A-rule'. The Journal of biological chemistry, 284(46):31680-31689, 2009. [ AbstractBeard, W.A., Shock, D.D., Batra, V.K., Pedersen, L.C., and Wilson, S.H. DNA Polymerase Beta Substrate Specificity: Side chain modulation of the 'A-rule'. The Journal of biological chemistry, 284(46):31680-31689, 2009. ]
  83. Upton, T.G., Kashemirov, B.A., McKenna, C.E., Goodman, M.F., Prakash, G.K., Kultyshev, R., Batra, V.K., Shock, D.D., Pedersen, L.C., Beard, W.A., and Wilson, S.H. Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Organic Letters, 11(9):1883-1886, 2009. [ AbstractUpton, T.G., Kashemirov, B.A., McKenna, C.E., Goodman, M.F., Prakash, G.K., Kultyshev, R., Batra, V.K., Shock, D.D., Pedersen, L.C., Beard, W.A., and Wilson, S.H. Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Organic Letters, 11(9):1883-1886, 2009. ]
  84. Tano, K., Chastain II, P.D., Asagoshi, K., Adachi, N., Sonoda, E., Kikuchi, K., Koyama, H., Nagata, K., Kaufman, D.G., Takeda, S., Wilson, S.H., Watanabe, M., Swenberg, J.A., and Nakamura, J. FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells. Molecular cancer research, 8(2):204-215, 2010. [ AbstractTano, K., Chastain II, P.D., Asagoshi, K., Adachi, N., Sonoda, E., Kikuchi, K., Koyama, H., Nagata, K., Kaufman, D.G., Takeda, S., Wilson, S.H., Watanabe, M., Swenberg, J.A., and Nakamura, J. FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells. Molecular cancer research, 8(2):204-215, 2010. ]
  85. Asagoshi, K., Liu, Y., Masaoka, A., Lan, L., Prasad, R., Horton, J.K., Brown, A.R., Wang, X.H., Sobol, R.W., Bdour, H.M., Taylor, J.S., Yasui, A., and Wilson, S.H. DNA polymerase beta-dependent long patch base excision repair in living cells. DNA repair, 9(2):109-119, 2010. [ AbstractAsagoshi, K., Liu, Y., Masaoka, A., Lan, L., Prasad, R., Horton, J.K., Brown, A.R., Wang, X.H., Sobol, R.W., Bdour, H.M., Taylor, J.S., Yasui, A., and Wilson, S.H. DNA polymerase beta-dependent long patch base excision repair in living cells. DNA repair, 9(2):109-119, 2010. ]
  86. Lui, Y., Prasad, R., and Wilson, S.H. HMGB1: Roles in base excision repair and related function. Biochimica et biophysica acta, 1799(1-2):119-130, 2010. [ AbstractLui, Y., Prasad, R., and Wilson, S.H. HMGB1: Roles in base excision repair and related function. Biochimica et biophysica acta, 1799(1-2):119-130, 2010. ]
  87. Heacock, M., Stefanick, D., Horton, J.K. and Wilson, S.H. Alkylation damage combined with PARP inhibition in cells results in S-phase dependent double-strand breaks. DNA repair, 9(8):929-936, 2010. [ AbstractHeacock, M., Stefanick, D., Horton, J.K. and Wilson, S.H. Alkylation damage combined with PARP inhibition in cells results in S-phase dependent double-strand breaks. DNA repair, 9(8):929-936, 2010. ]
  88. Batra, V.K., Beard, W.A., Hou, E.W., Pedersen, L.C., Prasad, R., and Wilson, S.H. Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Nature structural & molecular biology, 17(7):889-890, 2010. [ AbstractBatra, V.K., Beard, W.A., Hou, E.W., Pedersen, L.C., Prasad, R., and Wilson, S.H. Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Nature structural & molecular biology, 17(7):889-890, 2010. ]
  89. Poltoratsky, V., Heacock, M., Kissling, G.E., Prasad, R., Wilson, S.H. Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break. Molecular immunology 48(1-3):164-170, 2010. [ AbstractPoltoratsky, V., Heacock, M., Kissling, G.E., Prasad, R., Wilson, S.H. Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break. Molecular immunology 48(1-3):164-170, 2010. ]
  90. Khodyreva, S.N., Prasad, R., Ilina, E.S., Sukhanova, M.M., Kutuzov, Y., Liu, Y., Hou, E.W., Wilson, S.H., Lavrik, O.I. Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1). Proceedings of the National Academy of Sciences of the United States of America 107(51):22090-22095, 2010. [ AbstractKhodyreva, S.N., Prasad, R., Ilina, E.S., Sukhanova, M.M., Kutuzov, Y., Liu, Y., Hou, E.W., Wilson, S.H., Lavrik, O.I. Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1). Proceedings of the National Academy of Sciences of the United States of America 107(51):22090-22095, 2010. ]
  91. Braithwaite, E.K., Kedar, P.S., Stumpo, D.J., Bertocci, B., Freedman, J.H., Samson, L.D., Wilson, S.H. DNA Polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts. PloS one 5(8):e12229-, 2010. [ AbstractBraithwaite, E.K., Kedar, P.S., Stumpo, D.J., Bertocci, B., Freedman, J.H., Samson, L.D., Wilson, S.H. DNA Polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts. PloS one 5(8):e12229-, 2010. ]
  92. Cavanaugh, N.A., Beard, W.A., and Wilson, S.H. DNA Polymerase beta ribonucleotide discrimination: Insertion, misinsertion, extension, and coding. The Journal of biological chemistry, 285(32):24457-24465, 2010. [ AbstractCavanaugh, N.A., Beard, W.A., and Wilson, S.H. DNA Polymerase beta ribonucleotide discrimination: Insertion, misinsertion, extension, and coding. The Journal of biological chemistry, 285(32):24457-24465, 2010. ]
  93. Prasad R, Shock DD, Beard WA, Wilson SH. Passing the baton: Substrate channeling in mammalian base excision repair pathways. The Journal of biological chemistry 285(52):40479-40488, 2010. [ AbstractPrasad R, Shock DD, Beard WA, Wilson SH. Passing the baton: Substrate channeling in mammalian base excision repair pathways. The Journal of biological chemistry 285(52):40479-40488, 2010. ]
  94. Beard, WA, Batra, VK, Wilson, SH. DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine. Mutation research 703(1):18-23, 2010. [ AbstractBeard, WA, Batra, VK, Wilson, SH. DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine. Mutation research 703(1):18-23, 2010. ]
  95. Surya-Prakash, G.K., Zibinsky, M., Upton, T.G., Kashemirov, B.A., McKenna, C.E., Oertel, K., Goodman, M.F., Batra, V.K., Pedersen, L.C., Beard, W.A., Shock, D.D., Wilson, S.H., Olah, G.A. Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proceedings of the National Academy of Sciences of the United States of America 107(36):15693-15698, 2010. [ AbstractSurya-Prakash, G.K., Zibinsky, M., Upton, T.G., Kashemirov, B.A., McKenna, C.E., Oertel, K., Goodman, M.F., Batra, V.K., Pedersen, L.C., Beard, W.A., Shock, D.D., Wilson, S.H., Olah, G.A. Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proceedings of the National Academy of Sciences of the United States of America 107(36):15693-15698, 2010. ]
  96. Wilson SH, Beard WA, Shock DD, Batra VK, Cavanaugh NA , Prasad R, Hou EW, Liu Y, Asagoshi, K, Horton JK, Stefanick DF, Kedar PS , Carrozza, MJ, Masaoka A, Heacock ML. Base excision repair and design of small molecule inhibitors of human DNA polymerase β. Cellular and molecular life sciences 67(21):3633-47, 2010. [ AbstractWilson SH, Beard WA, Shock DD, Batra VK, Cavanaugh NA , Prasad R, Hou EW, Liu Y, Asagoshi, K, Horton JK, Stefanick DF, Kedar PS , Carrozza, MJ, Masaoka A, Heacock ML. Base excision repair and design of small molecule inhibitors of human DNA polymerase β. Cellular and molecular life sciences 67(21):3633-47, 2010. ]
  97. Horton, J.K., Stefanick, D.F., Zeng, J.Y., Carrozza, M.J., Wilson, S.H. Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition. DNA repair 10(2):225-234, 2011. [ AbstractHorton, J.K., Stefanick, D.F., Zeng, J.Y., Carrozza, M.J., Wilson, S.H. Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition. DNA repair 10(2):225-234, 2011. ]
  98. Cavanaugh, N.A., Beard, W.A., Batra, V.K., Perera, L., Pedersen, L.C., Wilson, S.H. Molecular insights into DNA polymerase deterrents for ribonucleotide insertion. The Journal of biological chemistry 286(36):31650-31660, 2011. [ AbstractCavanaugh, N.A., Beard, W.A., Batra, V.K., Perera, L., Pedersen, L.C., Wilson, S.H. Molecular insights into DNA polymerase deterrents for ribonucleotide insertion. The Journal of biological chemistry 286(36):31650-31660, 2011. ]
  99. Prasad, R., Beard, W.A., Batra, V.K., Liu, Y., Shock, D.D., Wilson, S.H. A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways. Mol. Biol. 45(4):586-600, 2011. [ AbstractPrasad, R., Beard, W.A., Batra, V.K., Liu, Y., Shock, D.D., Wilson, S.H. A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways. Mol. Biol. 45(4):586-600, 2011. ]
  100. Naidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM 3rd, Liu Y, Sanchez Z, Chaudhary P, Wilson SH, Waring MJ. 2011. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding.PLoS One. 6(9):e23679. doi: 10.1371/journal.pone.0023679. [ AbstractNaidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM 3rd, Liu Y, Sanchez Z, Chaudhary P, Wilson SH, Waring MJ. 2011. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One. 6(9):e23679. doi: 10.1371/journal.pone.0023679. ]
  101. Kedar, P.S., Stefanick, D.F., Horton, J.K. and Wilson, S.H. Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts. Molecular Cancer Research 10:360-368, 2012. [ AbstractKedar, P.S., Stefanick, D.F., Horton, J.K. and Wilson, S.H. Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts. Molecular Cancer Research 10:360-368, 2012. ]
  102. Liu, Y. and Wilson, S.H. Linkage between trinucleotide repeat expansion, oxidative stress and base excision repair. Trends in Biochemical Sciences 37:162-172, 2012.
  103. Kirby, T., DeRose, E., Cavanaugh, N., Beard, W.A., Shock, D.D., Mueller, G., Wilson, S.H. and London, R. Metal-induced DNA translocation leads to DNA polymerase conformational activation. Nucleic Acids Research 40: 2974-2983, 2012.
    [ AbstractKirby, T., DeRose, E., Cavanaugh, N., Beard, W.A., Shock, D.D., Mueller, G., Wilson, S.H. and London, R. Metal-induced DNA translocation leads to DNA polymerase conformational activation. Nucleic Acids Research 40: 2974-2983, 2012.
    ]
  104. Batra, V.K., Shock, D.D., Beard,W.A., McKenna, Charles E. and Wilson, S.H. Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion. Proceedings of the National Academy of Sciences, USA 109:113-118, 2012. [ AbstractBatra, V.K., Shock, D.D., Beard,W.A., McKenna, Charles E. and Wilson, S.H. Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion. Proceedings of the National Academy of Sciences, USA 109:113-118, 2012. ]
  105. Asagoshi, K., Lehmann, W., Braithwaite, E.K., Santana-Santos, L., Prasad, R., Freedman, J.K., Van Houten, B., and Wilson, S.H. Single nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Nucleic Acids Research 40:670-681, 2012 [ AbstractAsagoshi, K., Lehmann, W., Braithwaite, E.K., Santana-Santos, L., Prasad, R., Freedman, J.K., Van Houten, B., and Wilson, S.H. Single nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Nucleic Acids Research 40:670-681, 2012 ]
  106. Chamberlain, B.T., Batra, V.K., Beard, W.A., Kadina, A.P., Shock, D.D., Kashemirov, B.A., McKenna, C.E., Goodman, M.F. and Wilson, S.H. Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β. ChemBioChem 13:528-530, 2012. [ AbstractChamberlain, B.T., Batra, V.K., Beard, W.A., Kadina, A.P., Shock, D.D., Kashemirov, B.A., McKenna, C.E., Goodman, M.F. and Wilson, S.H. Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β. ChemBioChem 13:528-530, 2012. ]
  107. Nakano H, Free ME, Whitehead GS, Maruoka S, Wison RH, Nakano K, Cook DN. Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal immunology 5(1):53-65, 2012. [ AbstractNakano H, Free ME, Whitehead GS, Maruoka S, Wison RH, Nakano K, Cook DN. Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal immunology 5(1):53-65, 2012. ]
  108. Liu Y, Wilson SH. DNA base excision repair: a mechanism of trinucleotide repeat expansion. Trends in biochemical sciences, 37(4):162-72, 2012. [ AbstractLiu Y, Wilson SH. DNA base excision repair: a mechanism of trinucleotide repeat expansion. Trends in biochemical sciences, 37(4):162-72, 2012. ]
  109. Gassman NR, Stefanick DF, Kedar PS, Horton JK, Wilson SH. Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts. PLOS ONE 7(11):e49301, 2012. [ AbstractGassman NR, Stefanick DF, Kedar PS, Horton JK, Wilson SH. Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts. PLOS ONE 7(11):e49301, 2012. ]
  110. Freudenthal BD, Beard WA, Wilson SH. Structures of dNTP intermediate states during DNA polymerase active site assembly. Structure (London, England: 1993) 20(11):1829-1837, 2012. [ AbstractFreudenthal BD, Beard WA, Wilson SH. Structures of dNTP intermediate states during DNA polymerase active site assembly. Structure (London, England: 1993) 20(11):1829-1837, 2012. ]
  111. Wu Y, Zakharova VM, Kashemirov BA, Goodman MF, Batra VK, Wilson SH, McKenna CE. β [beta],γ[gamma]-CHF- and β [beta],γ[gamma]-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures, and absolute configurations of new stereochemical probes for DNA polymerases. Journal of the American Chemical Society 134(21):8734-8737, 2012. [ AbstractWu Y, Zakharova VM, Kashemirov BA, Goodman MF, Batra VK, Wilson SH, McKenna CE. β [beta],γ[gamma]-CHF- and β [beta],γ[gamma]-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures, and absolute configurations of new stereochemical probes for DNA polymerases. Journal of the American Chemical Society 134(21):8734-8737, 2012. ]
  112. Masaoka A, Gassman NR, Kedar PS, Prasad R, Hou E, Horton JK, Bustin M, Wilson SH. HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts. The Journal of biological chemistry, 287(22):27648-27658, 2012. [ AbstractMasaoka A, Gassman NR, Kedar PS, Prasad R, Hou E, Horton JK, Bustin M, Wilson SH. HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts. The Journal of biological chemistry, 287(22):27648-27658, 2012. ]
  113. Sassa A, Beard W.A., Prasad R., Wilson S.H. DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase. The Journal of biological chemistry 287(44):36702-36710, 2012. [ AbstractSassa A, Beard W.A., Prasad R., Wilson S.H. DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase. The Journal of biological chemistry 287(44):36702-36710, 2012. ]
  114. Freudenthal B.D., Beard W.A., and Wilson S.H. DNA Polymerase Minor Groove Interactions Modulate Mutagenic Bypass of a Templating 8-Oxoguanine Lesion. Nucleic acids research 41(3):1848-1858, 2013. [ AbstractFreudenthal B.D., Beard W.A., and Wilson S.H. DNA Polymerase Minor Groove Interactions Modulate Mutagenic Bypass of a Templating 8-Oxoguanine Lesion. Nucleic acids research 41(3):1848-1858, 2013. ]
  115. Horton JK, Wilson SH. Predicting Enhanced Cell Killing through PARP Inhibition. Molecular cancer research: MCR 11(1):13-18, 2013. [ AbstractHorton JK, Wilson SH. Predicting Enhanced Cell Killing through PARP Inhibition. Molecular cancer research: MCR 11(1):13-18, 2013. ]
  116. Sassa A, Beard WA, Shock DD, Wilson SH. Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity. Journal of visualized experiments: JoVE 78:e50695, 2013. [ AbstractSassa A, Beard WA, Shock DD, Wilson SH. Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity. Journal of visualized experiments: JoVE 78:e50695, 2013. ]
  117. Horton JK, Stefanick DF, Gassman NR, Williams JG, Gabel SA, Cuneo MJ, Prasad R, Kedar PS, Derose EF, Hou EW, London RE, Wilson SH. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA repair 2013 12(9):774-785. [ AbstractHorton JK, Stefanick DF, Gassman NR, Williams JG, Gabel SA, Cuneo MJ, Prasad R, Kedar PS, Derose EF, Hou EW, London RE, Wilson SH. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA repair 2013 12(9):774-785. ]
  118. An C, Beard WA, Chen D, Wilson SH, Makridakis NM. Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer.International journal of oncology43(4):1131-1140, 2013. [ AbstractAn C, Beard WA, Chen D, Wilson SH, Makridakis NM. Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer. International journal of oncology 43(4):1131-1140, 2013. ]
  119. Freudenthal BD, Beard WA, Shock DD, Wilson SH. Observing a DNA polymerase choose right from wrong. Cell 2013 154(1):157-168. [ AbstractFreudenthal BD, Beard WA, Shock DD, Wilson SH. Observing a DNA polymerase choose right from wrong. Cell 2013 154(1):157-168. ]
  120. Chary P, Beard WA, Wilson SH, Lloyd RS. Inhibition of HIV-1 reverse transcriptase-catalyzed synthesis by intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide adducts. PloS one 2013 8(9):e72131-. [ AbstractChary P, Beard WA, Wilson SH, Lloyd RS. Inhibition of HIV-1 reverse transcriptase-catalyzed synthesis by intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide adducts. PloS one 2013 8(9):e72131-. ]
  121. Vaidyanathan VG, Liang F, Beard WA, Shock DD, Wilson SH, Cho BP. 2013. Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site.J Biol Chem. 288(32):23573-85. doi: 10.1074/jbc.M113.476150. [ AbstractVaidyanathan VG, Liang F, Beard WA, Shock DD, Wilson SH, Cho BP. 2013. Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site. J Biol Chem. 288(32):23573-85. doi: 10.1074/jbc.M113.476150. ]
  122. Horton JK, Wilson SH. 2013. Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity.Front Oncol. 3:257. doi: 10.3389/fonc.2013.00257. [ AbstractHorton JK, Wilson SH. 2013. Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity. Front Oncol. 3:257. doi: 10.3389/fonc.2013.00257. ]
  123. Horton JK, Stefanick DF, Prasad R, Gassman NR, Kedar PS, Wilson SH. Base Excision Repair Defects Invoke Hypersensitivity to PARP Inhibition. Molecular cancer research: MCR 2014 12(8):11281139-1139. [ AbstractHorton JK, Stefanick DF, Prasad R, Gassman NR, Kedar PS, Wilson SH. Base Excision Repair Defects Invoke Hypersensitivity to PARP Inhibition. Molecular cancer research: MCR 2014 12(8):11281139-1139. ]
  124. Cağlayan M, Batra VK, Sassa A, Prasad R, Wilson SH. Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair. Nat Struct Mol Biol. 2014 May;21(5):497-9. doi: 10.1038/nsmb.2818. [ AbstractCağlayan M, Batra VK, Sassa A, Prasad R, Wilson SH. Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair. Nat Struct Mol Biol. 2014 May;21(5):497-9. doi: 10.1038/nsmb.2818. ]
  125. Sassa A, Çağlayan M, Dyrkheeva NS, Beard WA, Wilson SH. Base excision repair of tandem modifications in a methylated CpG dinucleotide. J Biol Chem. 2014 May 16;289(20):13996-4008. [ AbstractSassa A, Çağlayan M, Dyrkheeva NS, Beard WA, Wilson SH. Base excision repair of tandem modifications in a methylated CpG dinucleotide. J Biol Chem. 2014 May 16;289(20):13996-4008. ]
  126. Beard WA, Shock DD, Batra VK, Prasad R, Wilson SH. 2014. Substrate-induced DNA polymerase β activation.J Biol Chem. 289(45):31411-22. doi: 10.1074/jbc.M114.607432. [ AbstractBeard WA, Shock DD, Batra VK, Prasad R, Wilson SH. 2014. Substrate-induced DNA polymerase β activation. J Biol Chem. 289(45):31411-22. doi: 10.1074/jbc.M114.607432. ]
  127. Gassman NR, Coskun E, Stefanick DF, Horton JK, Jaruga P, Dizdaroglu M, Wilson SH. Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one 2015 10(2):e0118819-. [ AbstractGassman NR, Coskun E, Stefanick DF, Horton JK, Jaruga P, Dizdaroglu M, Wilson SH. Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one 2015 10(2):e0118819-. ]
  128. Çağlayan M, Horton JK, Prasad R, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Res. 2015 Feb 27;43(4):2271-81. doi: 10.1093/nar/gkv079. [ AbstractÇağlayan M, Horton JK, Prasad R, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Res. 2015 Feb 27;43(4):2271-81. doi: 10.1093/nar/gkv079. ]
  129. Freudenthal BD, Beard WA, Perera L, Shock DD, Kim T, Schlick T, Wilson SH. Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature 2015 517(7536):635-639. [ AbstractFreudenthal BD, Beard WA, Perera L, Shock DD, Kim T, Schlick T, Wilson SH. Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature 2015 517(7536):635-639. ]
  130. Gassman NR, Wilson SH. Micro-irradiation tools to visualize base excision repair and single-strand break repair.DNA repair2015 31():52-63. [ AbstractGassman NR, Wilson SH. Micro-irradiation tools to visualize base excision repair and single-strand break repair. DNA repair 2015 31():52-63. ]
  131. Caglayan M., Wilson S.H. Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. DNA Repair (Amst). 2015 Nov;35:85-9. doi: 10.1016/j.dnarep.2015.09.010. Epub 2015 Sep 16. [ AbstractCaglayan M., Wilson S.H. Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. DNA Repair (Amst). 2015 Nov;35:85-9. doi: 10.1016/j.dnarep.2015.09.010. Epub 2015 Sep 16. ]
  132. Horton JK, Gassman NR, Dunigan BD, Stefanick DF, Wilson SH. 2015. DNA polymerase β-dependent cell survival independent of XRCC1 expression.DNA Repair (Amst). 26:23-9. doi: 10.1016/j.dnarep.2014.11.008. [ AbstractHorton JK, Gassman NR, Dunigan BD, Stefanick DF, Wilson SH. 2015. DNA polymerase β-dependent cell survival independent of XRCC1 expression. DNA Repair (Amst). 26:23-9. doi: 10.1016/j.dnarep.2014.11.008. ]
  133. Sassa A, Caglayan M, Rodriguez Y, Beard WA, Wilson SH, Nohmi T, Honma M, Yasui M. Impact of ribonucleotide backbone on translesion synthesis and repair of 7,8-Dihydro-8-oxoguanine.Journal of Biological Chemistry(2016) 291: 24314 – 24323. [ AbstractSassa A, Caglayan M, Rodriguez Y, Beard WA, Wilson SH, Nohmi T, Honma M, Yasui M. Impact of ribonucleotide backbone on translesion synthesis and repair of 7,8-Dihydro-8-oxoguanine. Journal of Biological Chemistry (2016) 291: 24314 – 24323. ]
  134. Caglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts.Nucleic Acids Research(2017) 17: 10079 – 10088. [ AbstractCaglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic Acids Research (2017) 17: 10079 – 10088. ]
  135. Caglayan M, Wilson SH. Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure.Journal of Radiation Research -Review article (2017) 1093: 1 – 5. [ AbstractCaglayan M, Wilson SH. Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure. Journal of Radiation Research - Review article (2017) 1093: 1 – 5. ]
  136. Caglayan M, Horton JK, Da-Peng D, Stefanick DF, Wilson SH. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair.Nature Communications(2017) 8: 14045. [ AbstractCaglayan M, Horton JK, Da-Peng D, Stefanick DF, Wilson SH. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nature Communications (2017) 8: 14045. ]
  137. Prasad R, Caglayan M, Da-Peng D, Nadalutti CA, Gassman NR, Zhao M, Stefanick DF, Horton JK, Krasich R, Longley MJ, Copeland WC, Griffith JD, Wilson SH. DNA polymerase β: The missing link of the base excision repair machinery in mammalian mitochondria.DNA Repair(2017) 60: 77 – 88. [ AbstractPrasad R, Caglayan M, Da-Peng D, Nadalutti CA, Gassman NR, Zhao M, Stefanick DF, Horton JK, Krasich R, Longley MJ, Copeland WC, Griffith JD, Wilson SH. DNA polymerase β: The missing link of the base excision repair machinery in mammalian mitochondria. DNA Repair (2017) 60: 77 – 88. ]
  138. Çağlayan M, Horton JK, Dai D-P, Stefanick DF, Wilson SH. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair.Nature Communications2017 8):14045-. [ AbstractÇağlayan M, Horton JK, Dai D-P, Stefanick DF, Wilson SH. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nature Communications 2017 8):14045-. ]
  139. Perera L, Beard WA, Pedersen LG, Wilson SH. 2017. Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites.Inorg Chem. 56(1):313-320. doi: 10.1021/acs.inorgchem.6b02189. [ AbstractPerera L, Beard WA, Pedersen LG, Wilson SH. 2017. Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites. Inorg Chem. 56(1):313-320. doi: 10.1021/acs.inorgchem.6b02189. ]
  140. Horton JK, Stefanick DF, Caglayan M, Zhao ML, Gassman NR, Wilson SH. Cellular aprataxin deadenylation activity is stimulated by phosphorylated XRCC1.DNA Repair(2018) – 64: 26 – 33. [ AbstractHorton JK, Stefanick DF, Caglayan M, Zhao ML, Gassman NR, Wilson SH. Cellular aprataxin deadenylation activity is stimulated by phosphorylated XRCC1. DNA Repair (2018) – 64: 26 – 33. ]
  141. Howard M, Wilson SH. DNA scanning by base excision repair enzymes and implications for pathway coordination.DNA repair2018 71():101-107. [ AbstractHoward M, Wilson SH. DNA scanning by base excision repair enzymes and implications for pathway coordination. DNA repair 2018 71():101-107. ]
  142. Batra VK, Oertell K, Beard WA, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH. Mapping Functional Substrate-Enzyme Interactions in the pol β Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.Biochemistry2018 57(26):3934-3944. [ AbstractBatra VK, Oertell K, Beard WA, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH. Mapping Functional Substrate-Enzyme Interactions in the pol β Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry 2018 57(26):3934-3944. ]
  143. Oertell K, Kashemirov BA, Negahbani A, Minard C, Haratipour P, Alnajjar KS, Sweasy JB, Batra VK, Beard WA, Wilson SH, McKenna CE, Goodman MF. Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State.Biochemistry2018 57(26):3925-3933. [ AbstractOertell K, Kashemirov BA, Negahbani A, Minard C, Haratipour P, Alnajjar KS, Sweasy JB, Batra VK, Beard WA, Wilson SH, McKenna CE, Goodman MF. Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State. Biochemistry 2018 57(26):3925-3933. ]
  144. Çağlayan M, Wilson SH. 2018. Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate. Nat Commun. 9(1):4213. doi: 10.1038/s41467-018-06700-5. [ AbstractÇağlayan M, Wilson SH. 2018. Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate. Nat Commun. 9(1):4213. doi: 10.1038/s41467-018-06700-5. ]
  145. Smith MR, Shock DD, Beard WA, Greenberg MM, Freudenthal BD, Wilson SH. A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition.Nucleic Acids Research2019 47(6):3197-3207. [ AbstractSmith MR, Shock DD, Beard WA, Greenberg MM, Freudenthal BD, Wilson SH. A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. Nucleic Acids Research 2019 47(6):3197-3207. ]
  146. Prasad R, Horton JK, Dai DP, Wilson SH. Repair pathway for PARP-1 DNA-protein crosslinks.DNA Repair2019 73():71-77. [ AbstractPrasad R, Horton JK, Dai DP, Wilson SH. Repair pathway for PARP-1 DNA-protein crosslinks. DNA Repair 2019 73():71-77. ]
  147. Oertell K, Florián J, Haratipour P, Crans DC, Kashemirov BA, Wilson SH, McKenna CE, Goodman MF. 2019. A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β.Biochemistry. 58(13):1764-1773. doi: 10.1021/acs.biochem.9b00087. [ AbstractOertell K, Florián J, Haratipour P, Crans DC, Kashemirov BA, Wilson SH, McKenna CE, Goodman MF. 2019. A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β. Biochemistry. 58(13):1764-1773. doi: 10.1021/acs.biochem.9b00087. ]
  148. Howard MJ, Foley KG, Shock DD, Batra VK, Wilson SH. 2019. Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β.J Biol Chem. 294(18):7194-7201. doi: 10.1074/jbc.RA118.006809. [ AbstractHoward MJ, Foley KG, Shock DD, Batra VK, Wilson SH. 2019. Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β. J Biol Chem. 294(18):7194-7201. doi: 10.1074/jbc.RA118.006809. ]
  149. Jang S, Kumar N, Beckwitt EC, Kong M, Fouquerel E, Rapić-Otrin V, Prasad R, Watkins SC, Khuu C, Majumdar C, David SS, Wilson SH, Bruchez MP, Opresko PL, Van Houten B. 2019. Damage sensor role of UV-DDB during base excision repair.Nat Struct Mol Biol. 26(8):695-703. doi: 10.1038/s41594-019-0261-7. [ AbstractJang S, Kumar N, Beckwitt EC, Kong M, Fouquerel E, Rapić-Otrin V, Prasad R, Watkins SC, Khuu C, Majumdar C, David SS, Wilson SH, Bruchez MP, Opresko PL, Van Houten B. 2019. Damage sensor role of UV-DDB during base excision repair. Nat Struct Mol Biol. 26(8):695-703. doi: 10.1038/s41594-019-0261-7. ]
  150. Rodriguez Y, Horton JK, Wilson SH. 2019. Histone H3 lysine 56 acetylation enhances AP endonuclease 1-mediated repair of AP sites in nucleosome core particles. Biochemistry. 58(35):3646-3655. [ AbstractRodriguez Y, Horton JK, Wilson SH. 2019. Histone H3 lysine 56 acetylation enhances AP endonuclease 1-mediated repair of AP sites in nucleosome core particles. Biochemistry. 58(35):3646-3655. ]
  151. Nadalutti CA, Stefanick DF, Zhao ML, Horton JK, Prasad R, Brooks AM, Griffith JD, Wilson SH. Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts.Sci Rep2020. doi: 10.1038/s41598-020-61477-2 [Online 27 March 2020]. [ AbstractNadalutti CA, Stefanick DF, Zhao ML, Horton JK, Prasad R, Brooks AM, Griffith JD, Wilson SH. Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts. Sci Rep 2020. doi: 10.1038/s41598-020-61477-2 [Online 27 March 2020]. ]
  152. Liu Y, Rodriguez Y, Ross RL, Zhao R, Watts JA, Grunseich C, Bruzel A, Li D, Burdick JT, Prasad R, Crouch RJ, Limbach PA, Wilson SH, Cheung VG. 2020. RNA abasic sites in yeast and human cells.Proc Natl Acad Sci U S A; 117(34):20689-20695. [ AbstractLiu Y, Rodriguez Y, Ross RL, Zhao R, Watts JA, Grunseich C, Bruzel A, Li D, Burdick JT, Prasad R, Crouch RJ, Limbach PA, Wilson SH, Cheung VG. 2020. RNA abasic sites in yeast and human cells. Proc Natl Acad Sci U S A; 117(34):20689-20695. ]
  153. Beard WA. 2020. DNA polymerase β: Closing the gap between structure and function.DNA Repair (Amst).93:102910. [ AbstractBeard WA. 2020. DNA polymerase β: Closing the gap between structure and function. DNA Repair (Amst). 93:102910. ]
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  155. Batra VK, Alnajjar KS, Sweasy JB, McKenna CE, Goodman MF, Wilson SH. 2020. Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.Biochemistry. 59(8):955-963. doi: 10.1021/acs.biochem.9b01072. [ AbstractBatra VK, Alnajjar KS, Sweasy JB, McKenna CE, Goodman MF, Wilson SH. 2020. Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry. 59(8):955-963. doi: 10.1021/acs.biochem.9b01072. ]
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