Toxicoinformatics Group

Predictive Toxicology Branch

Scott S. Auerbach, Ph.D. Leader, Toxicoinformatics Tel 984-287-3108 Fax 919-541-3647 auerbachs@niehs.nih.gov

Research Summary

The Toxicoinformatics Group leads the development of data analytic approaches related to Tox21 data and provides informatics support for a variety of projects within the Biomolecular Screening Branch and across the National Toxicology Program.

Specific projects include:

Development of toxicogenomic models that predict apical toxicological outcomes
Evaluation of methods for scaling toxicogenomic technologies
In vitro / In vivo extrapolation
Analytics pipeline development for Tox21 high throughput screening data
Development of network-based inference approaches for biological read-across using Tox21 data
Development of software for genomic benchmark dose analysis

Scientists & Staff

Scott S. Auerbach, Ph.D. Leader, Toxicoinformatics Tel 984-287-3108 Fax 919-541-3647 auerbachs@niehs.nih.gov

Frank G. Chao, Ph.D. Computational Biologist Tel 984-287-4066 Fax 919-541-3647 chaof@niehs.nih.gov

Jui-Hua Hsieh, Ph.D. Staff Scientist Tel 984-287-3142 jui-hua.hsieh@nih.gov

Frederick M. Parham, Ph.D. Mathematical Statistician Tel 984-287-3169 parham@niehs.nih.gov

Zicong Wang Contractor - Software Developer Tel 984-287-4494 zicong.wang@nih.gov

Software

Tox21 Toolbox
The Tox21 toolbox contains useful tools for accessing and visualizing the Tox21 quantitative high throughput screening (qHTS) 10K library data, as well as integrating with other publicly available data.

Toxicology