TRlad Multi-Maker

The TRIad Multi-Marker (TRIMM) program performs max_Z2, and sum_log(P) tests, association tests for a child's or mother's genetic effects using multiple markers from triad families. Statistical significance is evaluated via permutation. It also outputs the nominated risk-haplotype-tagging alleles. For details, see Shi M , Umbach DM , Weinberg CR "Identification of Risk-related Haplotypes Using Multiple SNPs from Nuclear Families".

Download

is the ZIPPED set of the following 5 files:

  • R source code: TRIMM.r
  • Program documentation: TRIMM_Documentation.pdf
  • 3 Example files: geno.m geno.f geno.c

Contact


Min Shi
Min Shi, M.D., Ph.D. Staff Scientist Tel 984-287-3720 shi2@niehs.nih.gov

David M. Umbach
David M. Umbach, Ph.D. Staff Scientist Tel 984-287-3703 umbach@niehs.nih.gov

Clarice R. Weinberg
Clarice R. Weinberg, Ph.D. Principal Investigator Tel 984-287-3697 weinberg@niehs.nih.gov