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Epilepsy
CAPSTONE Centers for Multidisciplinary Research in Child Abuse and Neglect
Overview
NIH has funded research on the prevalence, causes, course, and immediate and long-term consequences of physical, sexual, and emotional child abuse and neglect—now called child maltreatment—for the past few decades. Results of these efforts indicate that child and adolescent victims of abuse are likely to have a legacy of physical and mental problems well into adulthood.
Timothy Petros Lab: Section on Cellular and Molecular Neurodevelopment
Proper brain function requires a balance between excitatory projection neurons and GABAergic inhibitory interneurons. Interneurons are an extremely heterogeneous cell population with distinct morphologies, connectivity, neurochemical markers, electrophysiological properties and transcriptomes. Abnormal development and function of interneurons has been linked to the pathobiology of numerous neurodevelopmental disorders such as epilepsy, schizophrenia and autism. Many genes implicated in these diseases are enriched in interneuron precursors.