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Opioid Misuse & Addiction
Innovatively Increasing PCP Prescribing of Buprenorphine: Measurement Based Care and Integrated Electronic Solution (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
Medication Treatment for Opioid-dependent Expecting Mothers (MOMs): A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
Developing a Prescription Opioid Registry across Diverse Health Systems (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
The goal of the proposed study is to expand the prescription opioid registry developed in study CTN 0061, across diverse health systems with harmonized EHR data, and leverage it to answer several key ‘next step’ research questions in response to the opioid crisis. We propose to adapt and expand the registry to 8 other health systems across the nation, initially within the Health System Node (HSN) to maximize efficiency in the short study timeframe, but with potential to be expanded to other nodes in the future.
A Foundation to Examine Reasons for Discontinuation for Buprenorphine Care in the Veterans Health Administration (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
This study will include analyses of VA databases to examine patient and organizational characteristics associated with buprenorphine termination during outpatient treatment for opioid use disorder. These analyses are critical for generating data and forming further hypotheses on how to implement targeted approaches to improve retention in treatment.
Adam J. Gordon, MD, MPH, FACP, DFASAM, CMRO
Professor of Medicine and Psychiatry
University of Utah Health
Inpatient versus Outpatient Treatment Outcomes for People with Opioid Use Disorder (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
This study will use a multi-state linked administrative database to compare opioid-related outcomes among Medicaid recipients admitted for treatment of opioid use disorder in outpatient and inpatient (or residential) facilities. Patient and organizational factors predicting higher retention in outpatient treatment for OUD will also be examined. These data will be used to generate hypotheses on how to improve retention in treatment.
Dan Hartung, PharmD, MPH
Associate Professor
Individual Level Predictive Modeling of Opioid Use Disorder Treatment Outcome (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
This project will develop models to predict individual patient’s risk for relapse (or dropout from treatment) when treated with medications for OUD including methadone, buprenorphine, or extended-release depot naltrexone.
Sean Luo, MD, Ph.D.
Assistant Professor
Columbia University
1051 Riverside Drive, Unit 66, New York, NY, 10033, US
Adaptation and Implementation of a Community Pharmacy-Based Prescription Drug Monitoring Program Opioid Risk Assessment Tool
A prescription drug monitoring program-based clinical decision support platform, with clinically actionable opioid risk information, is not widely available in the field of community pharmacy. This project will: (1) integrate risky opioid use thresholds established in CTN-0093 into a nationally scalable prescription drug monitoring platform; (2) adapt the platform to direct pharmacy staff in performing confirmatory opioid misuse screening, opioid medication misuse intervention, naloxone dispensation, and warm handoff; and (3) evaluate patient outcomes.
National Medication-Assisted Treatment Survey of Substance Use Disorder Programs Serving American Indian and Alaska Native People (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
This study seeks to provide a detailed description of the use of MATs for Opioid Use Disorders in health care systems and substance abuse treatment programs serving AI/AN communities, much-needed insights regarding the dynamics around the decision to implement such practices, and carefully formulated methods for more effective dissemination.
Douglas Novins, M.D.
Director, Native American and Telehealth Programs
Colorado University - Anschutz
Determining the Optimal Duration of Buprenorphine Treatment to Reduce the Risk of Relapse, Overdose, and Mortality (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
Rural Expansion of Medication Treatment for Opioid Use Disorder (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
The overall objective of this project is to investigate effective ways to expand access to MOUD in rural areas. Telemedicine (TM) offers an alternative or complementary approach to delivery of MOUD that is particularly attractive for implementation in rural areas. The CTN-0102 Feasibility study aims to examine the feasibility and acceptability of implementing TM in six rural primary care clinics with varying levels of OBOT capacity to inform implementation strategies for future larger randomized control trials.