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Schizophrenia
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Genome Instability and Chromatin Remodeling Section
Weidong Wang , PhD, Chief
Timothy Petros Lab: Section on Cellular and Molecular Neurodevelopment
Proper brain function requires a balance between excitatory projection neurons and GABAergic inhibitory interneurons. Interneurons are an extremely heterogeneous cell population with distinct morphologies, connectivity, neurochemical markers, electrophysiological properties and transcriptomes. Abnormal development and function of interneurons has been linked to the pathobiology of numerous neurodevelopmental disorders such as epilepsy, schizophrenia and autism. Many genes implicated in these diseases are enriched in interneuron precursors.