Stroke

This project involves investigations of signaling mechanisms that regulate stem cell self-renewal, neurogenesis, neurite outgrowth, synaptic plasticity and neuronal survival (Figure 3). This project has evolved from discoveries made in my laboratory during the past 3 decades which revealed roles for neurodegenerative disease-related proteins (e.g., APP, presenilin-1, DJ-1, TNF, and TLRs) in neural plasticity, and vice-versa (e.g., glutamate, BDNF and Notch).