Metabolic Health

The National Institute on Aging (NIA) is currently supporting 466 active clinical trials on Alzheimer’s disease and related dementias (AD/ADRD). These trials reflect diverse drug and mechanistic targets, as well as diversity in the stages of AD/ADRD they address.

Exploring the Relationship Between Aging and Disease

Geroscience seeks to understand the molecular and cellular mechanisms responsible for aging as a major driver of common chronic conditions and diseases of older people. Read about the latest advances in the field, funding opportunities, upcoming seminars, and more.

The National Institute on Aging’s Baltimore Longitudinal Study of Aging (BLSA) is America's longest-running scientific study of human aging. It began in 1958, when gerontology—the study of aging—was still very much in its infancy. Today, the BLSA is world-renowned, having generated thousands of scientific papers and made major contributions to our understanding of what it means to get older.

At 60 years and counting the National Institute on Aging's Baltimore Longitudinal Study of Aging (BLSA) is one of the longest-running studies in the world. The study was the first to ask a most basic question: What is normal aging?

There is still much to learn, but so far two major conclusions can be drawn from BLSA data. First, "normal" aging cannot be distinguished from disease. Although people's bodies change and can in some ways decline over time, these changes do not inevitably lead to diseases such as diabetes, hypertension, or dementia.

The Multicenter Osteoarthritis Study (MOST) is a longitudinal, prospective, observational study of knee osteoarthritis (OA) in older Americans with OA disease or at increased risk of developing it. The study is comprised of two clinical centers, a data coordinating center, and an analysis center.

This project involves investigations of signaling mechanisms that regulate stem cell self-renewal, neurogenesis, neurite outgrowth, synaptic plasticity and neuronal survival (Figure 3). This project has evolved from discoveries made in my laboratory during the past 3 decades which revealed roles for neurodegenerative disease-related proteins (e.g., APP, presenilin-1, DJ-1, TNF, and TLRs) in neural plasticity, and vice-versa (e.g., glutamate, BDNF and Notch).

The Clinical & Translational Neuroscience Section (CTNS), within the Laboratory of Behavioral Neuroscience at NIA, researches the biologic basis for how Alzheimer’s disease develops in humans. The findings from some of their research studies can be found by selecting the tabs below.

Alzheimer’s disease (AD) risk genes and measures of brain function, pathology, and the age-at-onset (AAO) of AD

With 2,832 participants, the ACTIVE Study is the largest study on cognitive training ever performed.