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Emergency Department-INitiated bupreNOrphine and VAlidaTIOn Network Trial (ED-INNOVATION) (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
This study will evaluate implementation of emergency department (ED)-initiated BUP in a large number of sites; compare extended release (XR)-BUP with sublingual (SL) BUP in ED patients with untreated OUD; and develop and validate electronic health record phenotypes of opioid-related illnesses to characterize ED visits, enhance active disease surveillance, and better identify patients eligible for study inclusion.
NCT04225598
Gail D'Onofrio, M.D., M.S.
Professor of Emergency Medicine
Lipid Peroxidation Unit
Christopher Ramsden , M.D., Ph.D., Chief
Mission
The Lipid Peroxidation Unit leverages expertise in brain lipids and lipoproteins to reveal molecular mechanisms and develop new treatments for age-related diseases, including chronic pain and Alzheimer’s disease.
Transgenics Section
Huaibin Cai , Ph.D., Chief
Our research focuses on elucidating the circuit- and cell-type–specific mechanisms that drive age-related neurodegenerative disorders, with a primary focus on Parkinson’s disease (PD). PD is a rapidly growing neurodegenerative condition that disproportionately affects older adults and manifests not only with progressive motor impairments but also with debilitating non-motor symptoms — such as depression, chronic pain, cognitive decline, and dementia — that remain inadequately treated.