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This study will build on lessons learned from the CHOICES pilot study (CTN-0055) and to advance understanding of XR-NTX adoption in HIV primary care settings. HIV primary care clinics are being selected to participate in an open-label trial of office-based XR-NTX in HIV-infected participants with untreated opioid use disorder or alcohol use disorders.

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Although accrediting organizations, funding sources, and other agencies require community treatment providers to monitor performance, there are no studies showing that this is an effective practice or that it helps addiction treatment patients, clinicians, or managers. This feasibility study tested whether one such strategy, feeding back performance data to clinic staff, could improve patient attendance and abstinence.

This project will identify strategies, facilitators, and barriers to retention and recruitment of pregnant individuals with opioid use disorder through pregnancy and the first year postpartum in the Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs) trial. We will conduct interviews of research team members from the 13 MOMS sites and focus groups of study participants. We will convene a Delphi panel with research team members and content experts to develop guidelines for future studies.