Immunology

Nan-ping Weng, M.D., Ph.D. , Senior Investigator

Patricia J. Gearhart , Ph.D., Chief

Ranjan Sen , Ph.D., Chief

Arya Biragyn , Ph.D., Chief

Jyoti Misra Sen, M.Sc., Ph.D., Chief

Research in our laboratory focuses on the effects of chronic systemic inflammation in the manifestation of Parkinson’s and Alzheimer’s diseases. In particular, we are interested in understanding the role of immune cells in the brain, the gut and in the traditional peripheral compartments in association with the gut-microbiota in the development of age-related chronic systemic inflammation, cellular senescence and neurodegeneration.

Welcome to the laboratory of Dr. Paul Love, located on the main campus of the National Institutes of Health in suburban Maryland.

Research in the Section on Hematopoiesis and Lymphocyte Biology is focused on elucidating the cellular and molecular processes that regulate mammalian hematopoiesis. Within this broad context, our studies are currently focused in three main areas.

Keiko Ozato and colleagues in the Section on Molecular Genetics of Immunity study the molecular mechanisms underlying innate immunity endowed by macrophages and dendritic cells. The main aim of the group are [a] to elucidate how MF/DC regulate transcription in response to pathogens and inflammatory signals and [b] clarify the role of chromatin in the process.