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Collaborative Pediatric Critical Care Research Network (CPCCRN)
Overview
Circadian Biology of Aging Unit
Circadian Biology of Aging Unit
Victoria Acosta-Rodriguez, Ph.D., Chief
The CBAU will investigate how circadian clocks age and contribute to the onset of chronic diseases. Circadian clocks control 24h rhythms in physiology, energy cycles, immune function, and longevity-related pathways. Dysregulation in these endogenous time-keeping mechanisms, due to aging or lifestyle, is detrimental to health and lifespan.
Matthias Machner Lab: Section on Microbial Pathogenesis
Our main research goal is to obtain mechanistic insight into the virulence strategies of microbial pathogens. As a model organism we use the bacterium Legionella pneumophila, the causative agent of a potentially fatal respiratory infection known as Legionnaires' disease. Contrary to what its name may imply, Legionnaires’ disease occurs in individuals of all ages, including children who receive respiratory therapy, newborns who recently underwent surgery or under-water birth, and children who are immune-compromised.