Pain

The Great Plains Initiative has two primary aims. Aim 1 is to determine community-defined needs for identifying and addressing substance use issues in order to create a Great Plains American Indian substance use research agenda. Such issues may involve a broad range of topics, such as specific substance misuse, barriers to treatment, the role of historical trauma in substance use, mistrust of research, and others as determined through the Community-based participatory research process.

Funded by the NIH HEAL Initiative^®

This project will develop models to predict individual patient’s risk for relapse (or dropout from treatment) when treated with medications for OUD including methadone, buprenorphine, or extended-release depot naltrexone.

Funded by the NIH HEAL Initiative^®

This study will use a multi-state linked administrative database to compare opioid-related outcomes among Medicaid recipients admitted for treatment of opioid use disorder in outpatient and inpatient (or residential) facilities. Patient and organizational factors predicting higher retention in outpatient treatment for OUD will also be examined. These data will be used to generate hypotheses on how to improve retention in treatment.

Funded by the NIH HEAL Initiative^®

Funded by the NIH HEAL Initiative^®

This study will include analyses of VA databases to examine patient and organizational characteristics associated with buprenorphine termination during outpatient treatment for opioid use disorder. These analyses are critical for generating data and forming further hypotheses on how to implement targeted approaches to improve retention in treatment.

Funded by the NIH HEAL Initiative^®

The goal of the proposed study is to expand the prescription opioid registry developed in study CTN 0061, across diverse health systems with harmonized EHR data, and leverage it to answer several key ‘next step’ research questions in response to the opioid crisis. We propose to adapt and expand the registry to 8 other health systems across the nation, initially within the Health System Node (HSN) to maximize efficiency in the short study timeframe, but with potential to be expanded to other nodes in the future.

Funded by the NIH HEAL Initiative℠

Funded by the NIH HEAL Initiative℠

Investigators will conduct in-depth qualitative interviews exploring experiences with prescription opioid and chronic pain stigma among cancer survivors prescribed opioids for moderate-to-severe chronic pain and caregivers to identify potential contributors to stigma in cancer survivors, with an emphasis on potential targets of future interventions and long-term health outcomes associated with stigma in survivorship.