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Harnessing Digital Health to Understand Clinical Trajectories of Opioid Use Disorder (D-TECT) (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
This is an observational study designed to (1) evaluate the feasibility and utility of digital health technology in a MOUD treatment population, and (2) capitalize on the availability of EHR data to relate passive and active sensing data to treatment retention and medication adherence.
Lisa A. Marsch, Ph.D.
Professor, Department of Psychiatry; Director, Center for Technology and Behavioral Health; Director, Dartmouth Psychiatric Research Center
Geisel School of Medicine at Dartmouth College
Ancillary Study of the Adoption and Sustainability of ED-Initiated Buprenorphine (NIH Heal Initiative)
Funded by the NIH HEAL Initiative®
Reducing Stigma Toward People with Opioid Use Disorder Among Primary Care Clinicians (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
Peer Intervention to Link Overdose survivors to Treatment (PILOT) (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
Randomized, Double-Blind, Placebo-Controlled Trial of Monthly Injectable Buprenorphine for Methamphetamine Use Disorder (MURB)(NIH HEAL Initiative)
Funded by the NIH HEAL Initiative℠
Optimizing Retention, Duration, and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
This study will 1) test strategies to improve OUD pharmacotherapy treatment retention and to improve outcomes among patients who have been successfully stabilized on OUD medications and want to stop medication; and 2) identify predictors of successful outcome and develop a stage model of relapse risk.
NCT04464980
Edward V. Nunes, Jr., M.D.
Professor of Clinical Psychiatry
Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute
Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE) (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
This study will examine whether 1) in hospitals with addiction medicine consultation services, hospital-initiated extended release buprenorphine (XR-BUP), compared to other OUD medications, results in increased OUD treatment engagement following hospital discharge; and 2) training hospitals without such consultation services on best practices for initiating OUD medication using consultation service hubs improves medication uptake in hospitals and following discharge.
NCT04345718
Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone (SWIFT): Improving the Real-World Effectiveness of Injection Naltrexone for Opioid Use Disorder (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
This study will examine if rapid transition to extended release naltrexone (XR-NTX) following detoxification yields a higher proportion of patients successfully receiving the first injection of XR-NTX compared to standard detoxification and naltrexone initiation and will assess facilitators and barriers to implementing rapid XR-NTX initiation.
NCT04762537
Adam Bisaga, M.D.
Research Psychiatrist
New York State Psychiatric Institute
1051 Riverside Drive, Unit 120 , New York, NY, 10032, US
Subthreshold Opioid Use Disorder Prevention (STOP) Trial (NIH HEAL Initiative)
Funded by the NIH HEAL Initiative®
This study will test the efficacy of a primary care Subthreshold Opioid Use Disorder Prevention (STOP) intervention to reduce unhealthy opioid use and examine the impact of STOP on progression to moderate-severe OUD, overdose risk behavior, and overdose events in adults with unhealthy use of illicit/prescribed opioids.
NCT04218201
Jennifer McNeely, M.D., M.S.
Associate Professor
New York University Grossman School of Medicine
180 Madison Avenue, 17th Floor, New York, NY, 10016, US